                                                 Toxicology Data Management System                                     Page: 1
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                   Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|A. D. LITTLE LABS  058806601  02/18/92   729      100(1)      51  (673)     61.7     POLYVINYL ALCOHOL                          |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ACETONE                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510912  10/31/88   729       50(1)      46  (718)     50.8     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510912  10/31/88   729       50(1)      39  (669)     51.6     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ETHANOL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510206  06/22/87   732       50(1)      43  (720)     51.5     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531204  01/20/93   727       50(1)      41  (704)     51.2     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516210  10/22/90   729       50(1)      40  (701)     52.1     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532304  12/30/92   735       50(1)      40  (699)     52.2     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101404  05/10/93   729       49(1)      41  (706)     51.3     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518806  12/20/90   733       50(1)      32  (704)     47.2     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510206  06/22/87   732       52(1)      38  (704)     54.1     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531204  01/20/93   729       50(1)      35  (699)     58.0     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516210  10/22/90   731       50(1)      44  (720)     55.4     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532304  12/30/92   736       50(1)      37  (704)     55.0     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101404  05/10/93   730       50(1)      34  (684)     55.9     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518806  12/20/90   740       50(1)      31  (690)     50.6     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508602  11/28/84   722       50(1)      45  (718)     52.0     O-BENZYL-P-CHLOROPHENOL                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508602  11/28/84   722       50(1)      37  (707)     49.8     O-BENZYL-P-CHLOROPHENOL                    |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                        Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518706  10/25/93   730       49(1)      38  (693)     53.7     METHYLEUGENOL                              |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518706  10/25/93   731       50(5)      31  (696)     63.2     METHYLEUGENOL                              |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 6
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512107  09/22/88   726       50(1)      40  (703)     52.4     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512107  09/22/88   726       51(1)      33  (676)     56.0     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 7
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516502  01/19/87   732       50(1)      41  (719)     48.8     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  058803604  10/31/94   729       50(1)      45  (709)     50.1     ANTHRAQUINONE                              |
|BATTELLE COLUMBUS  050508502  10/08/84   729       50(5)      46  (722)     48.4     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521203  06/22/89   729       50(1)      45  (709)     49.4     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058803506  04/16/92   726       50(1)      35  (686)     51.2     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508702  09/17/84   729       50(1)      47  (723)     47.1     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050508703  08/26/85   729       50(1)      43  (716)     47.4     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510004  10/09/86   739       52(1)      43  (686)     48.0     TRICRESYL PHOSPHATE                        |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516502  01/19/87   732       51(1)      40  (695)     53.2     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  058803604  10/31/94   730       50(5)      35  (695)     56.8     ANTHRAQUINONE                              |
|BATTELLE COLUMBUS  050508502  10/08/84   729       51(5)      42  (696)     53.8     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521203  06/22/89   735       50(1)      39  (704)     56.0     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058803506  04/16/92   727       50(5)      41  (704)     61.6     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508702  09/17/84   729       50(1)      38  (672)     51.6     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050508703  08/26/85   730       50(1)      40  (708)     49.9     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510004  10/09/86   739       50(1)      41  (715)     50.9     TRICRESYL PHOSPHATE                        |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 8
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513102  10/28/85   729       79(1)      58  (707)     51.3     SODIUM FLUORIDE                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513102  10/28/85   729       80(1)      53  (693)     57.4     SODIUM FLUORIDE                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 9
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050513402  01/23/86   736       50(1)      35  (690)     46.1     1,3-BUTADIENE                              |
|BATTELLE NORTHWEST 050519712  07/26/93   729       50(1)      39  (697)     52.2     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513304  04/07/88   733       50(1)      32  (690)     48.5     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513608  09/13/90   733       50(1)      27  (689)     49.4     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515606  08/23/90   733       50(1)      22  (662)     47.1     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520106  11/21/91   733       50(1)      34  (688)     51.6     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518007  09/16/93   733       50(1)      35  (687)     50.4     GALLIUM ARSENIDE                           |
|BATTELLE NORTHWEST 050518406  07/07/94   733       50(1)      31  (686)     52.5     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511402  11/18/85   733       50(1)      35  (685)     43.9     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807004  03/04/93   733       50(1)      28  (676)     51.0     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096802  08/09/90   733       50(1)      40  (712)     50.0     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050515804  03/22/90   733       50(1)      36  (689)     50.6     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520006  08/31/89   734       50(1)      31  (681)     52.1     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803404  11/09/89   733       50(1)      30  (670)     50.9     OZONE                                      |
|BATTELLE NORTHWEST 050518104  12/07/89   733       50(1)      32  (689)     51.2     TETRAHYDROFURAN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 10
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050513402  01/23/86   737       50(1)      37  (706)     48.1     1,3-BUTADIENE                              |
|BATTELLE NORTHWEST 050519712  07/26/93   731       50(1)      29  (688)     55.1     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513304  04/07/88   735       49(1)      28  (692)     49.8     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513608  09/13/90   734       50(1)      35  (686)     56.2     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515606  08/23/90   734       50(1)      34  (694)     48.9     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520106  11/21/91   734       50(1)      34  (690)     59.1     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518007  09/16/93   735       50(1)      36  (699)     51.3     GALLIUM ARSENIDE                           |
|BATTELLE NORTHWEST 050518406  07/07/94   735       50(1)      34  (699)     52.9     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511402  11/18/85   737       49(1)      31  (685)     46.9     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807004  03/04/93   735       50(1)      32  (681)     58.1     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096802  08/09/90   735       50(1)      28  (668)     49.9     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050515804  03/22/90   733       50(1)      25  (683)     49.6     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520006  08/31/89   734       50(1)      25  (662)     53.3     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803404  11/09/89   735       50(1)      29  (691)     54.2     OZONE                                      |
|BATTELLE NORTHWEST 050518104  12/07/89   733       50(1)      29  (615)     55.6     TETRAHYDROFURAN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 11
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BIOASSAY SYS CORP  050509102  12/18/84   729       50(1)      42  (694)     53.1     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509002  11/08/84   729       50(1)      43  (716)     54.4     COUMARIN                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BIOASSAY SYS CORP  050509102  12/18/84   729       51(1)      36  (669)     49.5     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509002  11/08/84   729       52(1)      33  (618)     52.9     COUMARIN                                   |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 12
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BROOKHAVEN         050510101  09/26/84   727       50(1)      40  (699)     48.6     METHYL BROMIDE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BROOKHAVEN         050510101  09/26/84   727       50(1)      36  (678)     49.5     METHYL BROMIDE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 13
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ACETONE                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050506907  06/06/89   731       50(1)      39  (700)     53.9     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050506907  06/06/89   741       50(1)      34  (714)     57.0     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 14
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050511102  06/25/85   729       52(1)      42  (685)     45.9     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510802  04/29/85   733       50(1)      39  (699)     44.7     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521402  05/11/88   730       62(1)      50  (706)     53.4     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050511102  06/25/85   733       50(1)      41  (701)     44.3     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510802  04/29/85   743       50(1)      37  (721)     45.8     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521402  05/11/88   737       60(1)      47  (702)     55.9     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 15
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050515002  07/31/86   741       50(1)      45  (729)     46.2     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508402  09/05/84   729       50(1)      43  (705)     48.4     TURMERIC, OLEORESIN (CURCUMIN)             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050515002  07/31/86   746       49(1)      37  (706)     45.1     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508402  09/05/84   731       50(1)      37  (697)     47.4     TURMERIC, OLEORESIN (CURCUMIN)             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 16
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050512702  10/08/85   730       51(1)      45  (707)     48.2     BARIUM CHLORIDE DIHYDRATE                  |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|E.G. & G. MASON    050512702  10/08/85   737       50(1)      38  (704)     50.0     BARIUM CHLORIDE DIHYDRATE                  |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 17
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ACETONE                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|HAZLETON           050510603  12/23/86   730       50(1)      43  (712)     39.5     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|HAZLETON           050510603  12/23/86   730       50(1)      41  (709)     37.9     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 18
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I050521004  03/05/90   729       50(1)      28  (636)     48.1     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518504  12/05/88   725       50(1)      37  (663)     48.4     ISOBUTYL NITRITE                           |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I050521004  03/05/90   730       50(1)      35  (689)     47.0     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518504  12/05/88   729       51(1)      32  (676)     48.5     ISOBUTYL NITRITE                           |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 19
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|LOVELACE RESEARCH  050512306  04/25/88   737       55(1)      19  (604)     42.6     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510706  09/29/88   737       59(1)      26  (644)     42.6     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512206  05/30/88   737       60(1)      26  (647)     43.9     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|LOVELACE RESEARCH  050512306  04/25/88   729       60(1)      41  (657)     41.1     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510706  09/29/88   733       58(1)      36  (677)     41.0     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512206  05/30/88   730       60(1)      34  (673)     42.6     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 20
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|MICROB. ASSOC.     050513002  08/13/85   739       50(1)      44  (708)     47.8     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506810  03/29/89   729       50(1)      41  (696)     50.7     CODEINE                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|MICROB. ASSOC.     050513002  08/13/85   744       49(1)      37  (692)     47.2     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506810  03/29/89   731       50(1)      36  (678)     53.2     CODEINE                                    |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 21
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050509301  09/25/84   729       50(1)      33  (690)     53.8     P-NITROANILINE                             |
|SOUTHERN RESEARCH  050509908  01/03/89   728       50(1)      40  (687)     54.4     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506710  10/15/90   730       50(1)      36  (705)     53.6     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050509301  09/25/84   729       50(1)      29  (662)     55.1     P-NITROANILINE                             |
|SOUTHERN RESEARCH  050509908  01/03/89   735       50(1)      41  (680)     51.6     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506710  10/15/90   731       50(1)      37  (700)     57.6     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 22
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                        Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900606  07/09/90   729       50(1)      32  (683)     50.2     AZT                                        |
|SOUTHERN RESEARCH  058900602  10/08/90   731       50(1)      36  (694)     47.7     AZT/INTERFERON A/INTERFERON AD             |
|SOUTHERN RESEARCH  058900604  01/14/91   729       50(1)      31  (694)     48.1     AZT/INTERFERON A/INTERFERON AD             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900606  07/09/90   731       50(1)      34  (689)     58.0     AZT                                        |
|SOUTHERN RESEARCH  058900602  10/08/90   729       50(1)      33  (662)     51.1     AZT/INTERFERON A/INTERFERON AD             |
|SOUTHERN RESEARCH  058900604  01/14/91   730       50(1)      37  (703)     53.7     AZT/INTERFERON A/INTERFERON AD             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 23
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050510304  03/13/89   736       50(1)      42  (710)     49.8     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512004  08/25/86   729       50(1)      39  (705)     46.0     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050521106  09/08/94   729       50(1)      41  (715)     51.1     EMODIN                                     |
|SOUTHERN RESEARCH  050509202  10/23/84   729       50(1)      35  (717)     49.2     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515504  05/25/88   730       50(1)      39  (709)     49.5     P-NITROBENZOIC ACID                        |
|SOUTHERN RESEARCH  050521705  11/29/89   727       50(1)      39  (711)     52.7     T-BUTYLHYDROQUINONE                        |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050510304  03/13/89   743       52(1)      37  (690)     54.5     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512004  08/25/86   729       50(1)      29  (681)     45.1     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050521106  09/08/94   732       50(5)      37  (702)     58.7     EMODIN                                     |
|SOUTHERN RESEARCH  050509202  10/23/84   729       50(1)      38  (694)     51.7     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515504  05/25/88   735       50(1)      38  (704)     52.1     P-NITROBENZOIC ACID                        |
|SOUTHERN RESEARCH  050521705  11/29/89   734       51(1)      38  (699)     56.2     T-BUTYLHYDROQUINONE                        |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 24
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050508902  11/29/84   733       50(1)      34  (706)     50.9     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514204  11/19/86   729       60(1)      27  (676)     53.3     TERT-BUTYL ALCOHOL                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050508902  11/29/84   733       50(1)      33  (683)     56.9     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514204  11/19/86   730       60(1)      36  (657)     60.5     TERT-BUTYL ALCOHOL                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 25
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                              Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                          Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900608  09/05/90   728       50(1)      27  (679)     51.1     INTERFERON A/INTERFERON AD                 |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900608  09/05/90   729       50(1)      25  (684)     63.1     INTERFERON A/INTERFERON AD                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 26
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|TSI MASON RESEARCH 050518204  11/27/90   729       50(1)      40  (701)     52.0     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|TSI MASON RESEARCH 050518204  11/27/90   737       50(1)      39  (696)     56.5     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 27
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|TSI MASON RESEARCH 050516006  01/02/91   729       50(1)      40  (689)     53.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530104  04/03/91   722       50(1)      35  (685)     55.4     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|TSI MASON RESEARCH 050516006  01/02/91   735       50(1)      32  (692)     60.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530104  04/03/91   729       50(1)      32  (671)     63.3     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 29
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                                                                       72/100(72%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                                                                    42/100(42%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors                                                         82/100(82%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma                                                        0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                                                                  2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,                                                    0/100(0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,                                                    14/100(14%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                                                                              1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                                                                            0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                                                                      0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant                                                          0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                                                                           0/94 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign                                                              2/94 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex                                                             0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant                                                           0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,                                                            2/94 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                                                                           0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                                                                  0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant                                                          0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or                                                        0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                                                                                                           |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                                                                                                                     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                                                                                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                                                                                                                        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                                                                              0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                                                                              9/100(9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                                                                            2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                                                                11/100(11%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                                                                           0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                                                                    1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                                                                    1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                                                                              3/94 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                                                                            0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                                                                 3/94 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                                                                              1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                                                                 1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                                                                           0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                                                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma                                                              56/99 (57%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma                                                            18/99 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                         18/99 (18%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                         61/99 (62%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,                                                           61/99 (62%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                                                                0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant                                                            0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma                                                         7/98 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma                                                       3/98 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or                                                   10/98 (10%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                                                                           0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                                                                          1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,                                                    0/100(0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,                                                             0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          5/97 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/97 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/97 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          1/97 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                                                                              0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                                                                            1/95 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                                                                 1/95 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                                                                         0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                                                                 0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                                                                           0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                                                                      0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                                                                              0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                                                                            0/59 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       9/86 (10%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       0/86 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       9/86 (10%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                                                                              0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                                                                            0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                                                                 0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                                                                                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                                                                                                           |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                                                                           0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                                                                     2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma                                                      2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                                                                   0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                                                                0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous                                                     0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or                                                              0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell                                                     0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,                                                         0/100(0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal                                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or                                                           0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,                                                      2/100(2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                                                                         2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,                                                               2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma                                                      0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,                                                     0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                                                                         0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                                                                           0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant                                                          0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or                                                           0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                                                                                                                        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                                                                                                                     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                                                                           0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant                                                            0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                                                                              0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                                                                       0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                                                                    0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                                                                          0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS                                                      0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                                                                              1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                                                                 1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                                                                              9/96 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                                                                            1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                                                                10/96 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or                                                           0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                                                                  0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                                                                             0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma                                                               0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                                                                           0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                                                                      0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                                                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: A. D. LITTLE LABS                         Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                                                                 1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 57
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)                                     34/50 (68%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)                                     11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         39/50 (78%)                                     37/50 (74%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/50 (4%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)                                       6/50 (12%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)                                       0/50 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              27/50 (54%)                                     22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            15/50 (30%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         15/50 (30%)                                      1/50 (2%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)                                     23/50 (46%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)                                     23/50 (46%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        15/50 (30%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)                                      2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/47 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/44 (9%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/44 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/44 (9%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              1/50 (2%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         1/50 (2%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       1/50 (2%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 85
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)   26/50 (52%)   38/50 (76%)         28/52 (54%)   39/50 (78%)   40/50 (80%)    |
|                                       27/50 (54%)   28/49 (57%)   43/50 (86%)         34/50 (68%)   37/50 (74%)   29/50 (58%)    |
| Overall Incidence               Total 197/299 (65.89%)Mean 65.86%  SD 13.67%    Total 207/302 (68.54%) Mean 68.64%  SD 10.75%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    16/50 (32%)   22/50 (44%)   21/50 (42%)         27/52 (52%)   23/50 (46%)   22/50 (44%)    |
|                                       29/50 (58%)   24/49 (49%)   39/50 (78%)         30/50 (60%)   22/50 (44%)   25/50 (50%)    |
| Overall Incidence               Total 151/299 (50.5%) Mean 50.5%   SD 15.95%    Total 149/302 (49.34%) Mean 49.32%  SD 6.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   35/50 (70%)   46/50 (92%)         41/52 (79%)   47/50 (94%)   47/50 (94%)    |
|                                       45/50 (90%)   42/49 (86%)   49/50 (98%)         44/50 (88%)   46/50 (92%)   45/50 (90%)    |
| Overall Incidence               Total 260/299 (86.96%)Mean 86.95%  SD 9.45%     Total 270/302 (89.4%)  Mean 89.47%  SD 5.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           3/52 (6%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     0/49 (0%)     3/50 (6%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2%      SD 2.53%     Total 11/302 (3.64%)   Mean 3.63%   SD 2.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     6/50 (12%)    2/50 (4%)           3/52 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        8/50 (16%)    4/49 (8%)     6/50 (12%)          3/50 (6%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 30/299 (10.03%) Mean 10.03%  SD 4.18%     Total 10/302 (3.31%)   Mean 3.29%   SD 2.37%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)    6/50 (12%)    2/50 (4%)           6/52 (12%)    3/50 (6%)     5/50 (10%)    |
|                                        9/50 (18%)    4/49 (8%)     9/50 (18%)          3/50 (6%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 36/299 (12.04%) Mean 12.03%  SD 5.49%     Total 21/302 (6.95%)   Mean 6.92%   SD 3.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           3/52 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     3/50 (6%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 11/302 (3.64%)   Mean 3.63%   SD 2.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     0/50 (0%)           7/52 (13%)   13/50 (26%)   12/50 (24%)    |
|      Lymphocytic, Mixed, NOS, or       4/50 (8%)     1/49 (2%)     5/50 (10%)          9/50 (18%)    3/50 (6%)     8/50 (16%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 15/299 (5.02%)  Mean 5.01%   SD 3.74%     Total 52/302 (17.22%)  Mean 17.24%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     5/50 (10%)          0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/49 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 3.95%     Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 7/301 (2.33%)    Mean 2.33%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     2/50 (4%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 7/301 (2.33%)    Mean 2.33%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/49 (0%)     0/48 (0%)     0/45 (0%)           0/52 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/283 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)     2/50 (4%)     0/50 (0%)           2/52 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     2/49 (4%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     3/50 (6%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.65%     Total 10/302 (3.31%)   Mean 3.31%   SD 2.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           2/52 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/302 (1.66%)    Mean 1.64%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     2/50 (4%)     0/50 (0%)           4/52 (8%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     2/49 (4%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     4/50 (8%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 2.11%     Total 15/302 (4.97%)   Mean 4.95%   SD 2.69%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/49 (4%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 3/298 (1.01%)   Mean 1.01%   SD 1.7%      Total 3/301 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/298 (0.67%)   Mean 0.67%   SD 1.03%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/49 (4%)     1/50 (2%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 5/298 (1.68%)   Mean 1.68%   SD 1.53%     Total 4/301 (1.33%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     3/50 (6%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 2.42%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 3/302 (0.99%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)     2/50 (4%)     0/50 (0%)           1/52 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        7/50 (14%)    1/49 (2%)     5/50 (10%)          2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 18/299 (6.02%)  Mean 6.01%   SD 5.21%     Total 4/302 (1.32%)    Mean 1.32%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              24/50 (48%)   22/50 (44%)   31/50 (62%)         20/52 (38%)   32/50 (64%)   32/50 (64%)    |
|                                       19/50 (38%)   22/49 (45%)   37/50 (74%)         23/50 (46%)   26/50 (52%)   18/50 (36%)    |
| Overall Incidence               Total 155/299 (51.84%)Mean 51.82%  SD 13.49%    Total 151/302 (50%)    Mean 50.08%  SD 12.17%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   12/50 (24%)   12/50 (24%)         12/52 (23%)    3/50 (6%)     5/50 (10%)    |
|                                       11/50 (22%)    9/49 (18%)   35/50 (70%)         10/50 (20%)    5/50 (10%)   10/50 (20%)    |
| Overall Incidence               Total 89/299 (29.77%) Mean 29.73%  SD 19.85%    Total 45/302 (14.9%)   Mean 14.85%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/50 (26%)   12/50 (24%)         12/52 (23%)    3/50 (6%)     5/50 (10%)    |
|      Hepatoblastoma                   11/50 (22%)    9/49 (18%)   35/50 (70%)         10/50 (20%)    6/50 (12%)   10/50 (20%)    |
| Overall Incidence               Total 90/299 (30.1%)  Mean 30.06%  SD 19.75%    Total 46/302 (15.23%)  Mean 15.18%  SD 6.78%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         29/50 (58%)   28/50 (56%)   39/50 (78%)         27/52 (52%)   33/50 (66%)   33/50 (66%)    |
|      Hepatocellular Adenoma           28/50 (56%)   29/49 (59%)   46/50 (92%)         28/50 (56%)   28/50 (56%)   27/50 (54%)    |
| Overall Incidence               Total 199/299 (66.56%)Mean 66.53%  SD 15.03%    Total 176/302 (58.28%) Mean 58.32%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           29/50 (58%)   29/50 (58%)   39/50 (78%)         27/52 (52%)   33/50 (66%)   33/50 (66%)    |
|      Hepatocellular Adenoma, or       28/50 (56%)   29/49 (59%)   46/50 (92%)         28/50 (56%)   28/50 (56%)   27/50 (54%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 200/299 (66.89%)Mean 66.86%  SD 14.76%    Total 176/302 (58.28%) Mean 58.32%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        13/50 (26%)   11/50 (22%)   11/50 (22%)          1/52 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        6/50 (12%)    7/49 (14%)   13/50 (26%)          1/50 (2%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 61/299 (20.4%)  Mean 20.38%  SD 5.93%     Total 13/302 (4.3%)    Mean 4.32%   SD 2.96%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     4/50 (8%)     5/50 (10%)          1/52 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        8/50 (16%)    7/49 (14%)    2/50 (4%)           7/50 (14%)    3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 27/299 (9.03%)  Mean 9.05%   SD 5.53%     Total 15/302 (4.97%)   Mean 4.99%   SD 4.87%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   15/50 (30%)   15/50 (30%)          2/52 (4%)     2/50 (4%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma     14/50 (28%)   12/49 (24%)   15/50 (30%)          8/50 (16%)    4/50 (8%)     5/50 (10%)    |
| Overall Incidence               Total 85/299 (28.43%) Mean 28.41%  SD 2.16%     Total 27/302 (8.94%)   Mean 8.97%   SD 4.72%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.65%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|      or Adenoma                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/52 (6%)     3/50 (6%)     2/49 (4%)     |
|                                                                                        4/50 (8%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 15/301 (4.98%)   Mean 4.98%   SD 2.74%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/52 (0%)     0/50 (0%)     3/49 (6%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/301 (1%)       Mean 1.02%   SD 2.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/52 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/47 (0%)     0/43 (0%)     0/41 (0%)           0/43 (0%)     0/37 (0%)     0/43 (0%)     |
|                                        0/40 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/38 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/262 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           6/52 (12%)    5/48 (10%)    7/50 (14%)    |
|   Adenoma                              0/48 (0%)     0/49 (0%)     1/49 (2%)          10/47 (21%)    9/50 (18%)    7/50 (14%)    |
| Overall Incidence               Total 1/287 (0.35%)   Mean 0.34%   SD 0.83%     Total 44/297 (14.81%)  Mean 14.87%  SD 4.08%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           0/52 (0%)     1/48 (2%)     0/50 (0%)     |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/287 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           6/52 (12%)    6/48 (13%)    7/50 (14%)    |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     1/49 (2%)          10/47 (21%)    9/50 (18%)    7/50 (14%)    |
| Overall Incidence               Total 1/287 (0.35%)   Mean 0.34%   SD 0.83%     Total 45/297 (15.15%)  Mean 15.22%  SD 3.7%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     1/45 (2%)     1/48 (2%)           0/52 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/287 (0.7%)    Mean 0.72%   SD 1.11%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/45 (0%)     0/48 (0%)           0/52 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/287 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     1/45 (2%)     1/48 (2%)           0/52 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/287 (0.7%)    Mean 0.72%   SD 1.11%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     2/50 (4%)           3/52 (6%)     2/50 (4%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 9/302 (2.98%)    Mean 2.96%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           2/52 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/302 (1.99%)    Mean 1.97%   SD 1.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/50 (2%)           3/52 (6%)     2/50 (4%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 9/302 (2.98%)    Mean 2.96%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 0.99%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     3/50 (6%)     1/50 (2%)           1/52 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     3/49 (6%)     2/50 (4%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.69%   SD 2.36%     Total 5/302 (1.66%)    Mean 1.65%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 6/302 (1.99%)    Mean 2%      SD 3.1%      |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/302 (1.66%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     2/50 (4%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.67%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        1/45 (2%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 1/238 (0.42%)   Mean 0.37%   SD 0.91%     Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     4/50 (8%)           3/52 (6%)     2/50 (4%)     4/50 (8%)     |
|                                        1/50 (2%)     2/49 (4%)     2/50 (4%)           4/50 (8%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 3.04%     Total 17/302 (5.63%)   Mean 5.63%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     4/50 (8%)           4/52 (8%)     2/50 (4%)     4/50 (8%)     |
|                                        1/50 (2%)     3/49 (6%)     2/50 (4%)           4/50 (8%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.69%   SD 2.96%     Total 18/302 (5.96%)   Mean 5.95%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/52 (2%)     1/50 (2%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence                                                               Total 11/302 (3.64%)   Mean 3.65%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/52 (2%)     1/50 (2%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence                                                               Total 12/302 (3.97%)   Mean 3.99%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)                                     28/50 (56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)                                     18/50 (36%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)                                     39/50 (78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)                                       9/50 (18%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           1/50 (2%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)                                       0/49 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 124
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 125
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              21/50 (42%)                                     11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             7/50 (14%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          7/50 (14%)                                      2/50 (4%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/50 (50%)                                     13/50 (26%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           25/50 (50%)                                     13/50 (26%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)                                       2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)                                      5/49 (10%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/49 (4%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/45 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       8/47 (17%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       0/47 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       8/47 (17%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       3/50 (6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       3/50 (6%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       1/50 (2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       1/50 (2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/42 (0%)                                       1/45 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/42 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/42 (0%)                                       1/45 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 144
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 145
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 147
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       33/49 (67%)                                     29/50 (58%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/49 (47%)                                     27/50 (54%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         41/49 (84%)                                     41/50 (82%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/49 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/49 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/49 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/49 (6%)                                      15/50 (30%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 148
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       0/50 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 149
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 150
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/49 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 151
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)                                       0/38 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/49 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/49 (0%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/49 (8%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 152
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 153
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 154
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 155
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              26/49 (53%)                                     20/50 (40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/49 (20%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/49 (20%)                                      7/50 (14%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/49 (63%)                                     25/50 (50%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/49 (63%)                                     25/50 (50%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 156
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/49 (22%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/49 (10%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/49 (31%)                                      7/50 (14%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 157
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 158
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/49 (0%)                                       2/50 (4%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 159
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 160
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/49 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 161
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 162
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/43 (0%)                                       0/36 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       5/48 (10%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       0/48 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       5/48 (10%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 163
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/45 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/45 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/45 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            1/49 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 1/49 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 164
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/49 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/49 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 165
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/49 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/49 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/49 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 166
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/49 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/49 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/49 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/49 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 167
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/49 (0%)                                       0/50 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/49 (0%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/49 (0%)                                       1/50 (2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/49 (0%)                                       1/50 (2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 168
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 169
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/49 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 170
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/37 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/49 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/49 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 171
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/49 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 172
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 173
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 175
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       36/50 (72%)                                     24/51 (47%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)                                     26/51 (51%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)                                     40/51 (78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)                                       4/51 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)                                       4/51 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    1/50 (2%)                                       0/51 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)                                       9/51 (18%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 176
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/51 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       1/51 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 177
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 178
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/51 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 179
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 180
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 181
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 182
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 183
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              26/50 (52%)                                     15/51 (29%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             6/50 (12%)                                      8/51 (16%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          6/50 (12%)                                      8/51 (16%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         30/50 (60%)                                     22/51 (43%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           30/50 (60%)                                     22/51 (43%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 184
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)                                      4/51 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 185
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 186
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/51 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 187
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 188
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/51 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 189
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 190
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/50 (8%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/50 (8%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 191
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/48 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/48 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 192
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/51 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 193
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/51 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/51 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 194
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/51 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 195
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/51 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/51 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/51 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/51 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 196
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 197
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 198
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 199
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 200
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 201
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 203
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)   27/50 (54%)   38/50 (76%)         27/51 (53%)   13/50 (26%)   21/51 (41%)    |
|                                       30/50 (60%)   26/50 (52%)   21/50 (42%)         29/50 (58%)   26/50 (52%)   22/50 (44%)    |
|                                       25/50 (50%)   26/52 (50%)                       12/50 (24%)   27/50 (54%)                  |
| Overall Incidence               Total 223/402 (55.47%)Mean 55.5%   SD 10.13%    Total 177/402 (44.03%) Mean 44.01%  SD 12.94%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   18/50 (36%)   20/50 (40%)         23/51 (45%)   21/50 (42%)   23/51 (45%)    |
|                                       17/50 (34%)   22/50 (44%)   17/50 (34%)         18/50 (36%)   20/50 (40%)   20/50 (40%)    |
|                                       25/50 (50%)   22/52 (42%)                       23/50 (46%)   22/50 (44%)                  |
| Overall Incidence               Total 158/402 (39.3%) Mean 39.29%  SD 5.87%     Total 170/402 (42.29%) Mean 42.27%  SD 3.43%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)   35/50 (70%)   46/50 (92%)         38/51 (75%)   28/50 (56%)   37/51 (73%)    |
|                                       37/50 (74%)   40/50 (80%)   32/50 (64%)         37/50 (74%)   34/50 (68%)   34/50 (68%)    |
|                                       37/50 (74%)   37/52 (71%)                       29/50 (58%)   40/50 (80%)                  |
| Overall Incidence               Total 302/402 (75.12%)Mean 75.14%  SD 8.26%     Total 277/402 (68.91%) Mean 68.88%  SD 8.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.74%   SD 1.02%     Total 4/402 (1%)       Mean 0.99%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     1/50 (2%)           2/51 (4%)     1/50 (2%)     2/51 (4%)     |
|                                        1/50 (2%)     3/50 (6%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        4/50 (8%)     5/52 (10%)                        3/50 (6%)     4/50 (8%)                   |
| Overall Incidence               Total 18/402 (4.48%)  Mean 4.45%   SD 3.07%     Total 17/402 (4.23%)   Mean 4.23%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     2/50 (4%)     1/50 (2%)           4/51 (8%)     1/50 (2%)     3/51 (6%)     |
|                                        1/50 (2%)     4/50 (8%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        4/50 (8%)     6/52 (12%)                        3/50 (6%)     4/50 (8%)                   |
| Overall Incidence               Total 21/402 (5.22%)  Mean 5.19%   SD 3.57%     Total 21/402 (5.22%)   Mean 5.22%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     2/50 (4%)     0/51 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 5/402 (1.24%)    Mean 1.25%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 204
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     3/50 (6%)     5/50 (10%)         13/51 (25%)   14/50 (28%)   15/51 (29%)    |
|      Lymphocytic, Mixed, NOS, or       2/50 (4%)     7/50 (14%)    6/50 (12%)          3/50 (6%)     8/50 (16%)   12/50 (24%)    |
|      Undifferentiated Cell Type        5/50 (10%)    3/52 (6%)                         9/50 (18%)    4/50 (8%)                   |
| Overall Incidence               Total 33/402 (8.21%)  Mean 8.22%   SD 3.79%     Total 78/402 (19.4%)   Mean 19.36%  SD 8.91%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                             11/50 (22%)    0/50 (0%)     0/49 (0%)           1/51 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        6/49 (12%)    1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     2/52 (4%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 20/400 (5%)     Mean 5.01%   SD 8.03%     Total 9/402 (2.24%)    Mean 2.25%   SD 2.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 205
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)      0/0 (0%)    10/50 (20%)          0/51 (0%)      0/0 (0%)     0/51 (0%)     |
|   Adenoma                              0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 11/351 (3.13%)  Mean 2.75%   SD 7.01%     Total 0/352 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     2/52 (4%)                         0/49 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 3/399 (0.75%)   Mean 0.74%   SD 1.45%     Total 3/396 (0.76%)    Mean 0.75%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/399 (0%)      Mean 0%      SD 0%        Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/399 (0%)      Mean 0%      SD 0%        Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/51 (2%)     |
|      Complex, Malignant, NOS           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     2/52 (4%)                         0/49 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 3/399 (0.75%)   Mean 0.74%   SD 1.45%     Total 3/396 (0.76%)    Mean 0.75%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 206
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.75%   SD 1.04%     Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 2/402 (0.5%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 207
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 208
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 209
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/42 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     1/51 (2%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/383 (0.26%)   Mean 0.25%   SD 0.69%     Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/50 (2%)     3/50 (6%)     4/50 (8%)           0/51 (0%)     2/50 (4%)     2/51 (4%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     5/50 (10%)                  |
| Overall Incidence               Total 13/402 (3.23%)  Mean 3.25%   SD 2.82%     Total 14/402 (3.48%)   Mean 3.49%   SD 3.34%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 210
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     1/50 (2%)           1/51 (2%)     0/50 (0%)     1/51 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/402 (1.49%)   Mean 1.49%   SD 1.41%     Total 5/402 (1.24%)    Mean 1.24%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     3/50 (6%)     5/50 (10%)          1/51 (2%)     2/50 (4%)     3/51 (6%)     |
|                                        3/50 (6%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     5/50 (10%)    1/50 (2%)     |
|                                        1/50 (2%)     1/52 (2%)                         0/50 (0%)     5/50 (10%)                  |
| Overall Incidence               Total 19/402 (4.73%)  Mean 4.74%   SD 2.83%     Total 19/402 (4.73%)   Mean 4.73%   SD 3.69%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 211
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 212
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 213
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 214
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     1/45 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     1/52 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/393 (0.76%)   Mean 0.77%   SD 1.06%     Total 2/399 (0.5%)     Mean 0.51%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/47 (2%)     0/52 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 3/393 (0.76%)   Mean 0.77%   SD 1.06%     Total 1/399 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     1/45 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/47 (2%)     1/52 (2%)                         1/49 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 6/393 (1.53%)   Mean 1.53%   SD 1.43%     Total 3/399 (0.75%)    Mean 0.76%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 215
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 216
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.24%   SD 0.68%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/49 (0%)     1/51 (2%)     |
|                                        1/49 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/401 (2%)      Mean 2.01%   SD 1.51%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)   21/50 (42%)   30/50 (60%)         17/51 (33%)    6/49 (12%)   12/51 (24%)    |
|                                       17/49 (35%)   22/50 (44%)   17/50 (34%)         25/50 (50%)   15/50 (30%)   10/50 (20%)    |
|                                       21/50 (42%)   18/52 (35%)                        7/50 (14%)   12/50 (24%)                  |
| Overall Incidence               Total 163/401 (40.65%)Mean 40.66%  SD 8.86%     Total 104/401 (25.94%) Mean 25.89%  SD 12.1%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/50 (22%)    8/50 (16%)    9/50 (18%)          4/51 (8%)     2/49 (4%)     3/51 (6%)     |
|                                        9/49 (18%)   12/50 (24%)    5/50 (10%)          9/50 (18%)    3/50 (6%)     4/50 (8%)     |
|                                        9/50 (18%)   15/52 (29%)                        5/50 (10%)   10/50 (20%)                  |
| Overall Incidence               Total 78/401 (19.45%) Mean 19.4%   SD 5.63%     Total 40/401 (9.98%)   Mean 9.98%   SD 5.86%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/50 (22%)    9/50 (18%)    9/50 (18%)          4/51 (8%)     2/49 (4%)     3/51 (6%)     |
|      Hepatoblastoma                    9/49 (18%)   12/50 (24%)    5/50 (10%)          9/50 (18%)    4/50 (8%)     4/50 (8%)     |
|                                        9/50 (18%)   15/52 (29%)                        5/50 (10%)   10/50 (20%)                  |
| Overall Incidence               Total 79/401 (19.7%)  Mean 19.65%  SD 5.5%      Total 41/401 (10.22%)  Mean 10.23%  SD 5.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/50 (50%)   25/50 (50%)   34/50 (68%)         20/51 (39%)    6/49 (12%)   13/51 (25%)    |
|      Hepatocellular Adenoma           23/49 (47%)   31/50 (62%)   20/50 (40%)         28/50 (56%)   16/50 (32%)   13/50 (26%)    |
|                                       25/50 (50%)   28/52 (54%)                       10/50 (20%)   21/50 (42%)                  |
| Overall Incidence               Total 211/401 (52.62%)Mean 52.6%   SD 8.77%     Total 127/401 (31.67%) Mean 31.62%  SD 13.83%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           25/50 (50%)   26/50 (52%)   34/50 (68%)         20/51 (39%)    6/49 (12%)   13/51 (25%)    |
|      Hepatocellular Adenoma, or       23/49 (47%)   31/50 (62%)   20/50 (40%)         28/50 (56%)   16/50 (32%)   13/50 (26%)    |
|      Hepatoblastoma                   25/50 (50%)   28/52 (54%)                       10/50 (20%)   21/50 (42%)                  |
| Overall Incidence               Total 212/401 (52.87%)Mean 52.85%  SD 8.71%     Total 127/401 (31.67%) Mean 31.62%  SD 13.83%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 217
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/49 (2%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 218
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)   11/50 (22%)    7/50 (14%)          2/51 (4%)     1/50 (2%)     2/51 (4%)     |
|                                       11/50 (22%)    7/50 (14%)    3/50 (6%)           4/50 (8%)     4/50 (8%)     4/50 (8%)     |
|                                        6/50 (12%)    7/52 (13%)                        2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 58/402 (14.43%) Mean 14.43%  SD 5.33%     Total 21/402 (5.22%)   Mean 5.23%   SD 2.39%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     8/50 (16%)    5/50 (10%)          0/51 (0%)     3/50 (6%)     4/51 (8%)     |
|                                        2/50 (4%)     4/50 (8%)     6/50 (12%)          1/50 (2%)     4/50 (8%)     0/50 (0%)     |
|                                        7/50 (14%)    1/52 (2%)                         1/50 (2%)     4/50 (8%)                   |
| Overall Incidence               Total 36/402 (8.96%)  Mean 8.99%   SD 4.91%     Total 17/402 (4.23%)   Mean 4.23%   SD 3.59%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    8/50 (16%)   17/50 (34%)   12/50 (24%)          2/51 (4%)     4/50 (8%)     6/51 (12%)    |
|      Alveolar/Bronchiolar Adenoma     13/50 (26%)   11/50 (22%)    9/50 (18%)          5/50 (10%)    7/50 (14%)    4/50 (8%)     |
|                                       13/50 (26%)    8/52 (15%)                        3/50 (6%)     5/50 (10%)                  |
| Overall Incidence               Total 91/402 (22.64%) Mean 22.67%  SD 6.24%     Total 36/402 (8.96%)   Mean 8.96%   SD 3.19%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 219
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 220
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 221
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/51 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 222
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 223
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 224
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     2/45 (4%)     2/51 (4%)     |
|                                                                                        1/50 (2%)     3/49 (6%)     1/48 (2%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 9/391 (2.3%)     Mean 2.32%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     1/48 (2%)                   |
| Overall Incidence                                                               Total 2/391 (0.51%)    Mean 0.51%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     1/48 (2%)                   |
| Overall Incidence                                                               Total 2/391 (0.51%)    Mean 0.51%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 225
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      1/50 (2%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        2/50 (4%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 2/391 (0.51%)    Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 226
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     1/48 (2%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/50 (2%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/391 (0.26%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/391 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 227
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     1/46 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/395 (0.25%)   Mean 0.27%   SD 0.77%     Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)     0/41 (0%)     0/46 (0%)           0/46 (0%)     0/39 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/31 (0%)     0/47 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
|                                        0/44 (0%)     0/52 (0%)                         0/47 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/358 (0%)      Mean 0%      SD 0%        Total 0/357 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/48 (0%)     0/46 (0%)           6/48 (13%)    4/47 (9%)     2/48 (4%)     |
|   Adenoma                              1/48 (2%)     0/45 (0%)     0/49 (0%)           2/50 (4%)     3/49 (6%)     7/49 (14%)    |
|                                        0/50 (0%)     0/50 (0%)                         1/49 (2%)     6/46 (13%)                  |
| Overall Incidence               Total 1/383 (0.26%)   Mean 0.26%   SD 0.74%     Total 31/386 (8.03%)   Mean 8.08%   SD 4.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/48 (0%)     0/46 (0%)           0/48 (0%)     0/47 (0%)     0/48 (0%)     |
|   Carcinoma                            0/48 (0%)     0/45 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/383 (0%)      Mean 0%      SD 0%        Total 0/386 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 228
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/48 (0%)     0/46 (0%)           6/48 (13%)    4/47 (9%)     2/48 (4%)     |
|   Carcinoma or Adenoma                 1/48 (2%)     0/45 (0%)     0/49 (0%)           2/50 (4%)     3/49 (6%)     7/49 (14%)    |
|                                        0/50 (0%)     0/50 (0%)                         1/49 (2%)     6/46 (13%)                  |
| Overall Incidence               Total 1/383 (0.26%)   Mean 0.26%   SD 0.74%     Total 31/386 (8.03%)   Mean 8.08%   SD 4.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)     0/48 (0%)     0/46 (0%)           0/48 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/45 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/383 (0%)      Mean 0%      SD 0%        Total 0/386 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)     0/48 (0%)     0/46 (0%)           1/48 (2%)     0/47 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/45 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/383 (0%)      Mean 0%      SD 0%        Total 1/386 (0.26%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)     0/48 (0%)     0/46 (0%)           1/48 (2%)     0/47 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/45 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/383 (0%)      Mean 0%      SD 0%        Total 1/386 (0.26%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 229
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 230
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 231
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 232
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.49%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.24%   SD 0.68%     Total 2/402 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 233
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 234
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/50 (4%)     2/51 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     3/50 (6%)     |
|      Histiocytoma                      0/50 (0%)     0/52 (0%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 17/402 (4.23%)   Mean 4.23%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/50 (4%)     2/51 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     3/50 (6%)     3/50 (6%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 16/402 (3.98%)   Mean 3.98%   SD 1.85%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/50 (4%)     2/51 (4%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     3/50 (6%)     3/50 (6%)     |
|      Histiocytoma                      0/50 (0%)     0/52 (0%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 17/402 (4.23%)   Mean 4.23%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 235
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/52 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 2/402 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     1/51 (2%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/396 (0%)      Mean 0%      SD 0%        Total 1/395 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/396 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/396 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 236
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     0/50 (0%)           2/51 (4%)     0/45 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     2/48 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        2/47 (4%)     4/52 (8%)                         3/49 (6%)     3/50 (6%)                   |
| Overall Incidence               Total 11/396 (2.78%)  Mean 2.76%   SD 2.76%     Total 10/395 (2.53%)   Mean 2.51%   SD 2.58%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/396 (0.25%)   Mean 0.26%   SD 0.74%     Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/52 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/396 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/50 (0%)     1/50 (2%)           2/51 (4%)     3/50 (6%)     1/51 (2%)     |
|      Papilloma Squamous                2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/52 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/402 (1.24%)   Mean 1.24%   SD 1.48%     Total 7/402 (1.74%)    Mean 1.74%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 237
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     1/50 (2%)           2/51 (4%)     3/50 (6%)     1/51 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.75%   SD 1.04%     Total 7/402 (1.74%)    Mean 1.74%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/52 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 238
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     1/49 (2%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 1/364 (0.27%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           0/50 (0%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/364 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 239
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           1/50 (2%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 1/364 (0.27%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/45 (0%)     0/39 (0%)           0/46 (0%)     0/44 (0%)     1/49 (2%)     |
|                                        0/43 (0%)     0/42 (0%)     0/36 (0%)           1/50 (2%)     0/45 (0%)     0/38 (0%)     |
|                                        0/40 (0%)     0/45 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 2/364 (0.55%)    Mean 0.51%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/400 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/394 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/394 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/400 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/394 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/45 (2%)     2/50 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 1/400 (0.25%)   Mean 0.25%   SD 0.71%     Total 6/394 (1.52%)    Mean 1.54%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 1/394 (0.25%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/45 (2%)     2/50 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/52 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 1/400 (0.25%)   Mean 0.25%   SD 0.71%     Total 7/394 (1.78%)    Mean 1.79%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 240
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 241
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/52 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.48%   SD 1.36%     Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/44 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/392 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/44 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/392 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/44 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/392 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 242
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/44 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/392 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/44 (0%)     0/51 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/392 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/402 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 243
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/402 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/402 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/51 (4%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 7/402 (1.74%)    Mean 1.74%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/402 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/51 (4%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 9/402 (2.24%)    Mean 2.24%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 244
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/52 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/402 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 245
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       57/79 (72%)                                     65/80 (81%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    41/79 (52%)                                     34/80 (43%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/79 (90%)                                     72/80 (90%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/79 (0%)                                       4/80 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/79 (4%)                                       3/80 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/79 (4%)                                       7/80 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/79 (1%)                                       5/80 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/79 (0%)                                       0/80 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/79 (5%)                                      11/80 (14%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 246
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/79 (0%)                                       2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              9/79 (11%)                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/79 (0%)                                       0/79 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/76 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/76 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/76 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/76 (0%)                                       0/76 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 247
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/79 (0%)                                       2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 248
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/79 (0%)                                       0/80 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 249
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/76 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/79 (9%)                                       4/80 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/79 (1%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 8/79 (10%)                                      5/80 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 250
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 251
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/78 (0%)                                       1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 252
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/78 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/78 (0%)                                       1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)                                       0/80 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)                                       0/80 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)                                       0/80 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)                                       0/80 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 253
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/79 (3%)                                       2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              50/79 (63%)                                     49/80 (61%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            25/79 (32%)                                     14/80 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/79 (32%)                                     14/80 (18%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         62/79 (78%)                                     55/80 (69%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           62/79 (78%)                                     55/80 (69%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 254
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/79 (14%)                                      5/80 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma      12/79 (15%)                                      3/80 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   23/79 (29%)                                      8/80 (10%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 255
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 256
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/79 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/79 (0%)                                       1/80 (1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 257
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 258
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/79 (0%)                                       0/80 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/78 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/78 (1%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 259
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 260
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/78 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/78 (0%)                                       1/80 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/70 (0%)                                       0/73 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)                                      25/80 (31%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)                                       0/80 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)                                      25/80 (31%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 261
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/71 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/71 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/71 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/78 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/78 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/79 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 262
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/79 (0%)                                       0/80 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/79 (0%)                                       0/80 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 263
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/79 (0%)                                       0/80 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/79 (0%)                                       0/80 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/79 (0%)                                       0/80 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/79 (1%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 264
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/79 (0%)                                       0/80 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/79 (0%)                                       0/80 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/79 (0%)                                       0/80 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/79 (0%)                                       0/80 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 265
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/79 (0%)                                       2/80 (3%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/79 (0%)                                       2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/79 (0%)                                       2/80 (3%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/79 (0%)                                       0/80 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/79 (0%)                                       0/80 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 266
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/79 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 267
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/79 (0%)                                       3/80 (4%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/79 (0%)                                       3/80 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/78 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/78 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 268
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/67 (0%)                                       0/76 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/79 (1%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 1/79 (1%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/79 (1%)                                       4/80 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/79 (1%)                                       4/80 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 269
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/79 (0%)                                       0/80 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 270
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/78 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 271
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/80 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/79 (0%)                                       0/80 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 273
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       36/50 (72%)   30/50 (60%)   24/50 (48%)         28/50 (56%)   31/50 (62%)   29/49 (59%)    |
|                                       31/50 (62%)   30/50 (60%)   31/50 (62%)         22/50 (44%)   25/50 (50%)   23/50 (46%)    |
|                                       30/50 (60%)   27/50 (54%)   29/50 (58%)         22/50 (44%)   32/50 (64%)   23/49 (47%)    |
|                                       30/50 (60%)   22/50 (44%)   28/50 (56%)         29/50 (58%)   26/50 (52%)   25/50 (50%)    |
|                                       31/50 (62%)   27/50 (54%)   36/50 (72%)         31/50 (62%)   33/50 (66%)   21/50 (42%)    |
| Overall Incidence               Total 442/750 (58.93%)Mean 58.93%  SD 7.44%     Total 400/748 (53.48%) Mean 53.47%  SD 8.06%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   19/50 (38%)   18/50 (36%)         15/50 (30%)   27/50 (54%)   23/49 (47%)    |
|                                       34/50 (68%)   33/50 (66%)   23/50 (46%)         20/50 (40%)   27/50 (54%)   20/50 (40%)    |
|                                       23/50 (46%)   33/50 (66%)   11/50 (22%)         26/50 (52%)   24/50 (48%)   21/49 (43%)    |
|                                       21/50 (42%)   28/50 (56%)   20/50 (40%)         29/50 (58%)   25/50 (50%)   28/50 (56%)    |
|                                       22/50 (44%)   25/50 (50%)   24/50 (48%)         26/50 (52%)   31/50 (62%)   21/50 (42%)    |
| Overall Incidence               Total 353/750 (47.07%)Mean 47.07%  SD 12.67%    Total 363/748 (48.53%) Mean 48.52%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         44/50 (88%)   42/50 (84%)   32/50 (64%)         35/50 (70%)   43/50 (86%)   35/49 (71%)    |
|                                       48/50 (96%)   49/50 (98%)   43/50 (86%)         34/50 (68%)   42/50 (84%)   36/50 (72%)    |
|                                       40/50 (80%)   44/50 (88%)   35/50 (70%)         36/50 (72%)   41/50 (82%)   34/49 (69%)    |
|                                       41/50 (82%)   40/50 (80%)   40/50 (80%)         43/50 (86%)   38/50 (76%)   40/50 (80%)    |
|                                       40/50 (80%)   40/50 (80%)   47/50 (94%)         38/50 (76%)   47/50 (94%)   34/50 (68%)    |
| Overall Incidence               Total 625/750 (83.33%)Mean 83.33%  SD 9.06%     Total 576/748 (77.01%) Mean 76.99%  SD 7.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     2/49 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           3/50 (6%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/750 (0.93%)   Mean 0.93%   SD 1.49%     Total 12/748 (1.6%)    Mean 1.61%   SD 2.3%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     2/50 (4%)           3/50 (6%)     2/50 (4%)     3/49 (6%)     |
|                                        3/50 (6%)     3/50 (6%)     1/50 (2%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           4/50 (8%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 23/750 (3.07%)  Mean 3.07%   SD 2.12%     Total 31/748 (4.14%)   Mean 4.14%   SD 2.57%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     1/50 (2%)     3/50 (6%)           5/50 (10%)    5/50 (10%)    5/49 (10%)    |
|                                        3/50 (6%)     5/50 (10%)    1/50 (2%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        5/50 (10%)    3/50 (6%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/49 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           7/50 (14%)    2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 30/750 (4%)     Mean 4%      SD 3.12%     Total 43/748 (5.75%)   Mean 5.75%   SD 3.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 274
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     2/49 (4%)     |
|                                        3/50 (6%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        3/50 (6%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     4/49 (8%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 18/750 (2.4%)   Mean 2.4%    SD 2.53%     Total 27/748 (3.61%)   Mean 3.62%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)     1/50 (2%)     3/50 (6%)           6/50 (12%)    7/50 (14%)   11/49 (22%)    |
|      Lymphocytic, Mixed, NOS, or       2/50 (4%)     1/50 (2%)     3/50 (6%)           7/50 (14%)    4/50 (8%)     6/50 (12%)    |
|      Undifferentiated Cell Type        1/50 (2%)     4/50 (8%)     2/50 (4%)           3/50 (6%)    12/50 (24%)   13/49 (27%)    |
|                                        4/50 (8%)     1/50 (2%)     2/50 (4%)          16/50 (32%)   12/50 (24%)    3/50 (6%)     |
|                                        3/50 (6%)     4/50 (8%)     2/50 (4%)           9/50 (18%)    7/50 (14%)    7/50 (14%)    |
| Overall Incidence               Total 37/750 (4.93%)  Mean 4.93%   SD 2.37%     Total 123/748 (16.44%) Mean 16.47%  SD 7.79%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 275
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 5/748 (0.67%)    Mean 0.67%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 5/748 (0.67%)    Mean 0.67%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/50 (4%)     2/50 (4%)     2/48 (4%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     6/50 (12%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/47 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/49 (4%)     2/50 (4%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        5/49 (10%)    0/50 (0%)     3/48 (6%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 28/739 (3.79%)  Mean 3.8%    SD 3.58%     Total 3/747 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 1/747 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 276
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                         0/0 (0%)     0/47 (0%)     0/49 (0%)            0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/689 (0%)      Mean 0%      SD 0%        Total 0/697 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     3/50 (6%)     2/48 (4%)     |
|                                        0/50 (0%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     4/50 (8%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     2/50 (4%)     0/49 (0%)     |
| Overall Incidence               Total 4/738 (0.54%)   Mean 0.55%   SD 0.94%     Total 15/741 (2.02%)   Mean 2.02%   SD 2.52%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/738 (0%)      Mean 0%      SD 0%        Total 0/741 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/738 (0.14%)   Mean 0.13%   SD 0.52%     Total 1/741 (0.13%)    Mean 0.14%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     3/50 (6%)     3/48 (6%)     |
|      Complex, Malignant, NOS           1/50 (2%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     4/50 (8%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     2/50 (4%)     0/49 (0%)     |
| Overall Incidence               Total 5/738 (0.68%)   Mean 0.68%   SD 1%        Total 16/741 (2.16%)   Mean 2.16%   SD 2.7%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/742 (0%)      Mean 0%      SD 0%        Total 0/745 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 277
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/742 (0%)      Mean 0%      SD 0%        Total 0/745 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/49 (0%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/48 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 3/742 (0.4%)    Mean 0.41%   SD 0.85%     Total 10/745 (1.34%)   Mean 1.34%   SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/742 (0%)      Mean 0%      SD 0%        Total 1/745 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/742 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/745 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/742 (0%)      Mean 0%      SD 0%        Total 0/745 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 278
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/750 (0.27%)   Mean 0.27%   SD 0.7%      Total 3/748 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 4/748 (0.53%)    Mean 0.53%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 4/748 (0.53%)    Mean 0.53%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 1/747 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 279
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 1/747 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/749 (0%)      Mean 0%      SD 0%        Total 0/747 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 280
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 281
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/746 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/746 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 1/746 (0.13%)   Mean 0.13%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/746 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 282
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)     0/42 (0%)     0/45 (0%)           0/46 (0%)     0/43 (0%)     0/42 (0%)     |
|                                        0/41 (0%)     0/37 (0%)     0/45 (0%)           0/45 (0%)     0/43 (0%)     0/43 (0%)     |
|                                        0/42 (0%)     0/42 (0%)     0/48 (0%)           0/47 (0%)     0/45 (0%)     0/48 (0%)     |
|                                        0/46 (0%)     0/47 (0%)     0/43 (0%)           0/46 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/43 (0%)     0/46 (0%)     0/42 (0%)           0/40 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/653 (0%)      Mean 0%      SD 0%        Total 0/669 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    3/50 (6%)     5/50 (10%)          8/50 (16%)    4/50 (8%)     3/49 (6%)     |
|                                        2/50 (4%)     4/50 (8%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                         0/0 (0%)     3/50 (6%)     7/50 (14%)           0/0 (0%)     1/50 (2%)     4/49 (8%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                         0/0 (0%)     1/50 (2%)     1/50 (2%)            0/0 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 40/650 (6.15%)  Mean 5.33%   SD 4.25%     Total 32/648 (4.94%)   Mean 4.29%   SD 4.08%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                         0/0 (0%)     1/50 (2%)     0/50 (0%)            0/0 (0%)     2/50 (4%)     1/49 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                         0/0 (0%)     0/50 (0%)     3/50 (6%)            0/0 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 10/650 (1.54%)  Mean 1.33%   SD 1.95%     Total 10/648 (1.54%)   Mean 1.34%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    3/50 (6%)     5/50 (10%)          8/50 (16%)    5/50 (10%)    3/49 (6%)     |
|                                        2/50 (4%)     4/50 (8%)     4/50 (8%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                         0/0 (0%)     4/50 (8%)     7/50 (14%)           0/0 (0%)     3/50 (6%)     5/49 (10%)    |
|                                        4/50 (8%)     3/50 (6%)     3/50 (6%)           2/50 (4%)     2/50 (4%)     3/50 (6%)     |
|                                         0/0 (0%)     1/50 (2%)     4/50 (8%)            0/0 (0%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 50/650 (7.69%)  Mean 6.67%   SD 3.98%     Total 42/648 (6.48%)   Mean 5.62%   SD 4.03%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 283
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/750 (0.27%)   Mean 0.27%   SD 0.7%      Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 284
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 285
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 3/748 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/750 (0.8%)    Mean 0.8%    SD 1.26%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 286
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/750 (0.8%)    Mean 0.8%    SD 1.26%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/750 (0.93%)   Mean 0.93%   SD 1.49%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 287
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 3/748 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     2/50 (4%)     0/47 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/47 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/49 (2%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 6/737 (0.81%)   Mean 0.8%    SD 1.48%     Total 8/739 (1.08%)    Mean 1.08%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/737 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 288
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     2/50 (4%)     0/47 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/47 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/49 (2%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 6/737 (0.81%)   Mean 0.8%    SD 1.48%     Total 8/739 (1.08%)    Mean 1.08%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/744 (0.13%)   Mean 0.14%   SD 0.53%     Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/744 (0.4%)    Mean 0.4%    SD 0.83%     Total 1/746 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 289
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/744 (0.13%)   Mean 0.13%   SD 0.52%     Total 2/746 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/744 (0.54%)   Mean 0.54%   SD 1.19%     Total 2/746 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/744 (0%)      Mean 0%      SD 0%        Total 1/746 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 290
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/748 (0.13%)   Mean 0.14%   SD 0.53%     Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/49 (2%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 12/748 (1.6%)   Mean 1.61%   SD 1.56%     Total 6/743 (0.81%)    Mean 0.81%   SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/748 (0.67%)   Mean 0.67%   SD 2.09%     Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              13/50 (26%)   22/50 (44%)   13/50 (26%)         11/49 (22%)   16/50 (32%)    4/49 (8%)     |
|                                       22/50 (44%)   22/50 (44%)   13/50 (26%)         17/50 (34%)    8/50 (16%)    7/50 (14%)    |
|                                       16/50 (32%)   19/49 (39%)   19/50 (38%)         11/50 (22%)   11/50 (22%)    5/49 (10%)    |
|                                       20/50 (40%)   12/49 (24%)   20/50 (40%)         20/47 (43%)    9/49 (18%)    9/50 (18%)    |
|                                       17/50 (34%)   23/50 (46%)   24/50 (48%)         14/50 (28%)   20/50 (40%)   12/50 (24%)    |
| Overall Incidence               Total 275/748 (36.76%)Mean 36.75%  SD 8.12%     Total 174/743 (23.42%) Mean 23.45%  SD 10.21%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 291
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/50 (22%)   10/50 (20%)    7/50 (14%)          4/49 (8%)    10/50 (20%)    7/49 (14%)    |
|                                       24/50 (48%)   23/50 (46%)   15/50 (30%)          4/50 (8%)    12/50 (24%)    9/50 (18%)    |
|                                       13/50 (26%)   15/49 (31%)    7/50 (14%)         12/50 (24%)    4/50 (8%)     4/49 (8%)     |
|                                       13/50 (26%)   17/49 (35%)   12/50 (24%)          5/47 (11%)    6/49 (12%)   19/50 (38%)    |
|                                       16/50 (32%)   12/50 (24%)   14/50 (28%)         10/50 (20%)   15/50 (30%)    6/50 (12%)    |
| Overall Incidence               Total 209/748 (27.94%)Mean 27.95%  SD 9.74%     Total 127/743 (17.09%) Mean 17.03%  SD 9.03%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/50 (22%)   10/50 (20%)    7/50 (14%)          4/49 (8%)    10/50 (20%)    7/49 (14%)    |
|      Hepatoblastoma                   24/50 (48%)   27/50 (54%)   15/50 (30%)          4/50 (8%)    12/50 (24%)    9/50 (18%)    |
|                                       13/50 (26%)   15/49 (31%)    7/50 (14%)         12/50 (24%)    4/50 (8%)     4/49 (8%)     |
|                                       13/50 (26%)   17/49 (35%)   12/50 (24%)          5/47 (11%)    6/49 (12%)   19/50 (38%)    |
|                                       16/50 (32%)   12/50 (24%)   14/50 (28%)         10/50 (20%)   15/50 (30%)    6/50 (12%)    |
| Overall Incidence               Total 213/748 (28.48%)Mean 28.49%  SD 10.94%    Total 127/743 (17.09%) Mean 17.03%  SD 9.03%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/50 (42%)   30/50 (60%)   19/50 (38%)         15/49 (31%)   22/50 (44%)    9/49 (18%)    |
|      Hepatocellular Adenoma           43/50 (86%)   38/50 (76%)   28/50 (56%)         20/50 (40%)   18/50 (36%)   14/50 (28%)    |
|                                       26/50 (52%)   32/49 (65%)   24/50 (48%)         21/50 (42%)   14/50 (28%)    9/49 (18%)    |
|                                       30/50 (60%)   27/49 (55%)   30/50 (60%)         23/47 (49%)   12/49 (24%)   23/50 (46%)    |
|                                       29/50 (58%)   30/50 (60%)   35/50 (70%)         19/50 (38%)   27/50 (54%)   17/50 (34%)    |
| Overall Incidence               Total 442/748 (59.09%)Mean 59.09%  SD 12.27%    Total 263/743 (35.4%)  Mean 35.38%  SD 10.76%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           21/50 (42%)   30/50 (60%)   19/50 (38%)         15/49 (31%)   22/50 (44%)    9/49 (18%)    |
|      Hepatocellular Adenoma, or       43/50 (86%)   40/50 (80%)   28/50 (56%)         20/50 (40%)   18/50 (36%)   14/50 (28%)    |
|      Hepatoblastoma                   26/50 (52%)   32/49 (65%)   24/50 (48%)         21/50 (42%)   14/50 (28%)    9/49 (18%)    |
|                                       30/50 (60%)   27/49 (55%)   30/50 (60%)         23/47 (49%)   12/49 (24%)   23/50 (46%)    |
|                                       29/50 (58%)   30/50 (60%)   35/50 (70%)         19/50 (38%)   27/50 (54%)   17/50 (34%)    |
| Overall Incidence               Total 444/748 (59.36%)Mean 59.36%  SD 12.7%     Total 263/743 (35.4%)  Mean 35.38%  SD 10.76%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/47 (2%)     2/49 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 7/748 (0.94%)   Mean 0.93%   SD 1.67%     Total 12/743 (1.62%)   Mean 1.61%   SD 1.73%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 292
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/748 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/747 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 293
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        18/50 (36%)    9/50 (18%)    6/50 (12%)          4/50 (8%)     7/50 (14%)    7/49 (14%)    |
|                                        8/50 (16%)    9/50 (18%)   16/50 (32%)          2/50 (4%)     3/50 (6%)     2/50 (4%)     |
|                                       13/50 (26%)    8/48 (17%)   11/49 (22%)          6/50 (12%)    2/50 (4%)     4/48 (8%)     |
|                                       12/50 (24%)    5/50 (10%)    9/50 (18%)          2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                       11/50 (22%)    6/50 (12%)   18/50 (36%)          3/50 (6%)     4/50 (8%)     1/50 (2%)     |
| Overall Incidence               Total 159/747 (21.29%)Mean 21.27%  SD 8.28%     Total 48/746 (6.43%)   Mean 6.45%   SD 4.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)    5/50 (10%)    4/50 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        6/50 (12%)    4/50 (8%)     4/50 (8%)           2/50 (4%)     1/50 (2%)     4/50 (8%)     |
|                                        3/50 (6%)    10/48 (21%)    0/49 (0%)           1/50 (2%)     1/50 (2%)     3/48 (6%)     |
|                                        6/50 (12%)    7/50 (14%)    2/50 (4%)           4/49 (8%)     3/50 (6%)     2/50 (4%)     |
|                                        2/50 (4%)     8/50 (16%)    6/50 (12%)          0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 72/747 (9.64%)  Mean 9.66%   SD 5.21%     Total 25/746 (3.35%)   Mean 3.36%   SD 2.73%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   21/50 (42%)   14/50 (28%)   10/50 (20%)          4/50 (8%)     7/50 (14%)    8/49 (16%)    |
|      Alveolar/Bronchiolar Adenoma     13/50 (26%)   11/50 (22%)   20/50 (40%)          4/50 (8%)     4/50 (8%)     6/50 (12%)    |
|                                       15/50 (30%)   18/48 (38%)   11/49 (22%)          7/50 (14%)    3/50 (6%)     7/48 (15%)    |
|                                       17/50 (34%)   12/50 (24%)   11/50 (22%)          6/49 (12%)    3/50 (6%)     3/50 (6%)     |
|                                       13/50 (26%)   14/50 (28%)   21/50 (42%)          3/50 (6%)     6/50 (12%)    2/50 (4%)     |
| Overall Incidence               Total 221/747 (29.59%)Mean 29.6%   SD 7.65%     Total 73/746 (9.79%)   Mean 9.81%   SD 3.94%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/747 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/747 (0%)      Mean 0%      SD 0%        Total 1/746 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/747 (0.13%)   Mean 0.13%   SD 0.52%     Total 2/746 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 294
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/747 (0%)      Mean 0%      SD 0%        Total 1/746 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/747 (0%)      Mean 0%      SD 0%        Total 0/746 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 295
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 296
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 18/748 (2.41%)   Mean 2.41%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 297
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 18/748 (2.41%)   Mean 2.41%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 18/748 (2.41%)   Mean 2.41%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 298
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/750 (0.27%)   Mean 0.27%   SD 1.03%     Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 299
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/745 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/745 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/745 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 300
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/745 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 2/748 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              2/49 (4%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/49 (2%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 3/734 (0.41%)    Mean 0.41%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 301
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/734 (0.14%)    Mean 0.14%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)     0/50 (0%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/734 (0.14%)    Mean 0.14%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)     2/50 (4%)     1/48 (2%)     |
|                                                                                        1/48 (2%)     2/48 (4%)     2/50 (4%)     |
|                                                                                        2/49 (4%)     1/49 (2%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        2/47 (4%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 16/734 (2.18%)   Mean 2.18%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/49 (2%)     |
|                                                                                        1/48 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 4/734 (0.54%)    Mean 0.55%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 302
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|      Malignant, NOS                                                                    0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/49 (2%)     |
|                                                                                        1/48 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 4/734 (0.54%)    Mean 0.55%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     1/50 (2%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 3/734 (0.41%)    Mean 0.41%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 303
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     0/50 (0%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     2/49 (4%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 6/734 (0.82%)    Mean 0.82%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        1/48 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 3/734 (0.41%)    Mean 0.41%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/734 (0.14%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/734 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/734 (0.14%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 304
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/734 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                                                                        1/48 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/734 (0.27%)    Mean 0.27%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 1/739 (0.14%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 1/739 (0.14%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 305
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 1/739 (0.14%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/739 (0%)      Mean 0%      SD 0%        Total 0/739 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/39 (0%)     0/26 (0%)     0/39 (0%)           0/40 (0%)     0/31 (0%)     0/24 (0%)     |
|                                        0/35 (0%)     0/19 (0%)     0/32 (0%)           0/35 (0%)     0/25 (0%)     0/32 (0%)     |
|                                        0/34 (0%)     0/21 (0%)     0/31 (0%)           0/39 (0%)     0/27 (0%)     0/34 (0%)     |
|                                        0/41 (0%)     0/43 (0%)     0/36 (0%)           0/35 (0%)     0/44 (0%)     0/31 (0%)     |
|                                        0/41 (0%)     0/47 (0%)     0/39 (0%)           1/33 (3%)     0/44 (0%)     0/30 (0%)     |
| Overall Incidence               Total 0/523 (0%)      Mean 0%      SD 0%        Total 1/504 (0.2%)     Mean 0.2%    SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 306
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/50 (2%)     0/49 (0%)     0/46 (0%)           7/50 (14%)    5/50 (10%)   14/48 (29%)    |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/50 (0%)           4/49 (8%)    11/48 (23%)    7/48 (15%)    |
|                                        0/48 (0%)     1/46 (2%)     0/49 (0%)           3/46 (7%)    20/49 (41%)    8/49 (16%)    |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           8/49 (16%)   10/50 (20%)    9/49 (18%)    |
|                                        1/47 (2%)     0/47 (0%)     1/45 (2%)           9/50 (18%)   17/50 (34%)   10/47 (21%)    |
| Overall Incidence               Total 5/720 (0.69%)   Mean 0.7%    SD 1.03%     Total 142/732 (19.4%)  Mean 19.36%  SD 9.4%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     1/49 (2%)           0/46 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     0/45 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/720 (0.14%)   Mean 0.14%   SD 0.53%     Total 2/732 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/50 (2%)     0/49 (0%)     0/46 (0%)           7/50 (14%)    6/50 (12%)   14/48 (29%)    |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/50 (0%)           4/49 (8%)    11/48 (23%)    7/48 (15%)    |
|                                        0/48 (0%)     1/46 (2%)     1/49 (2%)           3/46 (7%)    21/49 (43%)    8/49 (16%)    |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           8/49 (16%)   10/50 (20%)    9/49 (18%)    |
|                                        1/47 (2%)     0/47 (0%)     1/45 (2%)           9/50 (18%)   17/50 (34%)   10/47 (21%)    |
| Overall Incidence               Total 6/720 (0.83%)   Mean 0.84%   SD 1.07%     Total 144/732 (19.67%) Mean 19.63%  SD 9.62%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)     1/46 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/48 (0%)     1/48 (2%)     |
|                                        0/48 (0%)     1/46 (2%)     0/49 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     1/47 (2%)     0/45 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 3/720 (0.42%)   Mean 0.43%   SD 0.89%     Total 2/732 (0.27%)    Mean 0.27%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     0/45 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/720 (0%)      Mean 0%      SD 0%        Total 0/732 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     1/46 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/48 (0%)     1/48 (2%)     |
|                                        0/48 (0%)     1/46 (2%)     0/49 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     1/47 (2%)     0/45 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 3/720 (0.42%)   Mean 0.43%   SD 0.89%     Total 2/732 (0.27%)    Mean 0.27%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 307
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/725 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/725 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/725 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/743 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/743 (0%)      Mean 0%      SD 0%        Total 0/743 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 308
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 309
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 310
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 311
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Keratoacanthoma,                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 4/748 (0.53%)    Mean 0.53%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/750 (0.4%)    Mean 0.4%    SD 0.83%     Total 5/748 (0.67%)    Mean 0.67%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 312
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 313
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 3/748 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 314
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           4/50 (8%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/750 (1.07%)   Mean 1.07%   SD 1.28%     Total 23/748 (3.07%)   Mean 3.07%   SD 3.53%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/750 (0.27%)   Mean 0.27%   SD 0.7%      Total 2/748 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           4/50 (8%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/750 (1.07%)   Mean 1.07%   SD 1.28%     Total 23/748 (3.07%)   Mean 3.07%   SD 3.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 315
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           4/50 (8%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 6/750 (0.8%)    Mean 0.8%    SD 1.01%     Total 21/748 (2.81%)   Mean 2.8%    SD 3.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 316
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/740 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/740 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/740 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 317
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           2/49 (4%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     1/47 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           3/49 (6%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
| Overall Incidence               Total 7/740 (0.95%)   Mean 0.95%   SD 1.3%      Total 12/744 (1.61%)   Mean 1.62%   SD 1.92%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/740 (0%)      Mean 0%      SD 0%        Total 1/744 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/740 (0%)      Mean 0%      SD 0%        Total 0/744 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 318
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/750 (0.8%)    Mean 0.8%    SD 1.01%     Total 6/748 (0.8%)     Mean 0.8%    SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/750 (0.8%)    Mean 0.8%    SD 1.01%     Total 5/748 (0.67%)    Mean 0.67%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/750 (0.27%)   Mean 0.27%   SD 0.7%      Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 319
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 4/747 (0.54%)   Mean 0.53%   SD 1.19%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/747 (0.13%)   Mean 0.13%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 320
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     0/43 (0%)     1/44 (2%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 1/572 (0.17%)   Mean 0.15%   SD 0.59%     Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           1/43 (2%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.16%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           1/43 (2%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.16%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 321
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           0/43 (0%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/47 (0%)           0/43 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/41 (0%)     0/39 (0%)     0/30 (0%)           0/47 (0%)     0/41 (0%)     0/40 (0%)     |
|                                        0/33 (0%)     0/39 (0%)     0/35 (0%)           1/43 (2%)     0/47 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/572 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.16%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/742 (0.13%)   Mean 0.14%   SD 0.53%     Total 1/746 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/742 (0%)      Mean 0%      SD 0%        Total 1/746 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/742 (0.13%)   Mean 0.14%   SD 0.53%     Total 2/746 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     2/50 (4%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     3/50 (6%)     |
|                                        1/50 (2%)     1/48 (2%)     1/48 (2%)           1/50 (2%)     4/50 (8%)     1/49 (2%)     |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           1/48 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     4/49 (8%)           4/50 (8%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 20/742 (2.7%)   Mean 2.69%   SD 2.25%     Total 31/746 (4.16%)   Mean 4.15%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 322
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/48 (2%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     3/50 (6%)     1/50 (2%)     |
| Overall Incidence               Total 4/742 (0.54%)   Mean 0.54%   SD 0.93%     Total 5/746 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     2/50 (4%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     4/50 (8%)     3/50 (6%)     |
|                                        2/50 (4%)     2/48 (4%)     1/48 (2%)           1/50 (2%)     4/50 (8%)     1/49 (2%)     |
|                                        0/50 (0%)     4/50 (8%)     2/50 (4%)           1/48 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     4/49 (8%)           4/50 (8%)     5/50 (10%)    3/50 (6%)     |
| Overall Incidence               Total 24/742 (3.23%)  Mean 3.23%   SD 2.51%     Total 36/746 (4.83%)   Mean 4.81%   SD 2.8%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 323
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 2/748 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 324
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 1/748 (0.13%)    Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/750 (0.4%)    Mean 0.4%    SD 0.83%     Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     1/50 (2%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/736 (0.14%)   Mean 0.13%   SD 0.52%     Total 0/720 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/736 (0%)      Mean 0%      SD 0%        Total 0/720 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/736 (0%)      Mean 0%      SD 0%        Total 0/720 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 325
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/736 (0%)      Mean 0%      SD 0%        Total 0/720 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     1/50 (2%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/736 (0.14%)   Mean 0.13%   SD 0.52%     Total 0/720 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/748 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/748 (0.13%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 326
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/748 (0.67%)    Mean 0.67%   SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/748 (0.27%)    Mean 0.27%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/748 (0.27%)    Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                                                                        3/50 (6%)     2/50 (4%)     4/50 (8%)     |
|                                                                                        4/50 (8%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence                                                               Total 28/748 (3.74%)   Mean 3.74%   SD 2.49%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 327
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/748 (0.27%)    Mean 0.27%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                                                                        3/50 (6%)     2/50 (4%)     4/50 (8%)     |
|                                                                                        4/50 (8%)     3/50 (6%)     1/50 (2%)     |
| Overall Incidence                                                               Total 30/748 (4.01%)   Mean 4.01%   SD 2.51%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 328
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/750 (0%)      Mean 0%      SD 0%        Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/750 (0.13%)   Mean 0.13%   SD 0.52%     Total 0/748 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 329
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)   38/50 (76%)                       17/51 (33%)   20/52 (38%)                  |
| Overall Incidence               Total 73/100 (73%)    Mean 73%     SD 4.24%     Total 37/103 (35.92%)  Mean 35.9%   SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   15/50 (30%)                        9/51 (18%)    8/52 (15%)                  |
| Overall Incidence               Total 32/100 (32%)    Mean 32%     SD 2.83%     Total 17/103 (16.5%)   Mean 16.52%  SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)   42/50 (84%)                       24/51 (47%)   25/52 (48%)                  |
| Overall Incidence               Total 84/100 (84%)    Mean 84%     SD 0%        Total 49/103 (47.57%)  Mean 47.57%  SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         1/51 (2%)     1/52 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/103 (1.94%)    Mean 1.94%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)                         4/51 (8%)     5/52 (10%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 9/103 (8.74%)    Mean 8.73%   SD 1.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 330
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           1/50 (2%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     1/49 (2%)                         0/47 (0%)     2/49 (4%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 2/96 (2.08%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/49 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/49 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     1/49 (2%)                         0/47 (0%)     2/49 (4%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 2/96 (2.08%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 331
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 332
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/48 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 333
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/40 (0%)                         0/45 (0%)     0/41 (0%)                   |
| Overall Incidence               Total 0/85 (0%)       Mean 0%      SD 0%        Total 0/86 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    3/50 (6%)                         1/51 (2%)     1/52 (2%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 2.83%     Total 2/103 (1.94%)    Mean 1.94%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 5/50 (10%)    3/50 (6%)                         1/51 (2%)     1/52 (2%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 2.83%     Total 2/103 (1.94%)    Mean 1.94%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 334
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 335
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     2/50 (4%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            3/50 (6%)     2/50 (4%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 4/50 (8%)     2/50 (4%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)     0/49 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 336
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/49 (2%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1.02%   SD 1.44%     Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/49 (2%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1.02%   SD 1.44%     Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 337
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              29/50 (58%)   26/50 (52%)                       10/51 (20%)    8/50 (16%)                  |
| Overall Incidence               Total 55/100 (55%)    Mean 55%     SD 4.24%     Total 18/101 (17.82%)  Mean 17.8%   SD 2.55%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/50 (22%)   11/50 (22%)                        3/51 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 22/100 (22%)    Mean 22%     SD 0%        Total 3/101 (2.97%)    Mean 2.94%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/50 (22%)   11/50 (22%)                        3/51 (6%)     0/50 (0%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 22/100 (22%)    Mean 22%     SD 0%        Total 3/101 (2.97%)    Mean 2.94%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         36/50 (72%)   35/50 (70%)                       13/51 (25%)    8/50 (16%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 71/100 (71%)    Mean 71%     SD 1.41%     Total 21/101 (20.79%)  Mean 20.75%  SD 6.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           36/50 (72%)   35/50 (70%)                       13/51 (25%)    8/50 (16%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 71/100 (71%)    Mean 71%     SD 1.41%     Total 21/101 (20.79%)  Mean 20.75%  SD 6.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 338
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   14/50 (28%)                        2/51 (4%)     2/51 (4%)                   |
| Overall Incidence               Total 22/100 (22%)    Mean 22%     SD 8.49%     Total 4/102 (3.92%)    Mean 3.92%   SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    9/50 (18%)   14/50 (28%)                        2/51 (4%)     2/51 (4%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 23/100 (23%)    Mean 23%     SD 7.07%     Total 4/102 (3.92%)    Mean 3.92%   SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 339
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 340
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 341
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 342
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/50 (2%)     2/51 (4%)                   |
| Overall Incidence                                                               Total 3/101 (2.97%)    Mean 2.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/51 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 343
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 344
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/48 (0%)     0/49 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/39 (0%)     0/38 (0%)                         0/38 (0%)     0/35 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/73 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/42 (0%)                         9/47 (19%)    4/45 (9%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 13/92 (14.13%)   Mean 14.02%  SD 7.25%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/42 (0%)                         0/47 (0%)     0/45 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/92 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/42 (0%)                         9/47 (19%)    4/45 (9%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 13/92 (14.13%)   Mean 14.02%  SD 7.25%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 345
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)     0/42 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/92 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)     0/42 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/92 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)     0/42 (0%)                         0/47 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/92 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/102 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 346
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 347
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 348
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 349
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)                         0/51 (0%)     2/52 (4%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/103 (1.94%)    Mean 1.92%   SD 2.72%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/52 (2%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 350
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         1/51 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/49 (2%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 351
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     2/50 (4%)                         2/51 (4%)     1/52 (2%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 1.41%     Total 3/103 (2.91%)    Mean 2.92%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)     2/50 (4%)                         2/51 (4%)     1/52 (2%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 3/103 (2.91%)    Mean 2.92%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)     3/49 (6%)                                                                   |
| Overall Incidence               Total 4/98 (4.08%)    Mean 4.08%   SD 2.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/49 (0%)                                                                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 352
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/41 (0%)     0/47 (0%)                         0/45 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/88 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)     0/49 (0%)                         0/48 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/49 (0%)                         0/48 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)                         0/48 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)     0/49 (0%)                         0/48 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/49 (0%)     0/49 (0%)                         0/48 (0%)     1/47 (2%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.06%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)                         0/48 (0%)     1/47 (2%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.06%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 353
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/49 (0%)                         0/45 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 354
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/45 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/45 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/49 (0%)                         0/45 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/49 (0%)                         0/45 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)     1/52 (2%)                   |
| Overall Incidence                                                               Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     1/52 (2%)                   |
| Overall Incidence                                                               Total 1/103 (0.97%)    Mean 0.96%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 355
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BIOASSAY SYS CORP                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/51 (2%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/51 (2%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 1/103 (0.97%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/51 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/103 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 357
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       29/50 (58%)                                     16/50 (32%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    16/50 (32%)                                     16/50 (32%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         37/50 (74%)                                     27/50 (54%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)                                       4/50 (8%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 358
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       1/50 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 359
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 360
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 361
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 362
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 363
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 364
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 365
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)                                      4/50 (8%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)                                     10/50 (20%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)                                     10/50 (20%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 366
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 367
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 368
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 369
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 370
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 371
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 372
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/43 (0%)                                       5/49 (10%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/43 (0%)                                       1/49 (2%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/43 (0%)                                       6/49 (12%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 373
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/43 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/43 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/43 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/45 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/45 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/45 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 374
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 375
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       1/50 (2%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 376
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 377
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 378
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 379
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 380
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/41 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/49 (2%)                                       2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/49 (2%)                                       3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 381
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 382
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 383
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BROOKHAVEN                                Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 385
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)                                     34/50 (68%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    22/50 (44%)                                     31/50 (62%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)                                     46/50 (92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)                                      10/50 (20%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 386
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)                                       2/48 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)                                       0/48 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/48 (2%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/48 (2%)                                       2/48 (4%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 387
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/49 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 388
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 389
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/46 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 390
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 391
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 392
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 393
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              24/50 (48%)                                     30/50 (60%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)                                     13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          8/50 (16%)                                     13/50 (26%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/50 (54%)                                     33/50 (66%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/50 (54%)                                     33/50 (66%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 394
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       7/50 (14%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   18/50 (36%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 395
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 396
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 397
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 398
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 399
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 400
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/37 (0%)                                       0/40 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       5/44 (11%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       0/44 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       5/44 (11%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 401
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/45 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/45 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/45 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 402
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 403
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 404
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 405
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       2/50 (4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       2/50 (4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 406
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/48 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 407
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 408
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/39 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          1/39 (3%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      1/39 (3%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 409
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 410
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 411
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 413
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       19/52 (37%)   25/50 (50%)   36/62 (58%)         17/50 (34%)   24/50 (48%)   30/60 (50%)    |
| Overall Incidence               Total 80/164 (48.78%) Mean 48.2%   SD 10.88%    Total 71/160 (44.38%)  Mean 44%     SD 8.72%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    15/52 (29%)   15/50 (30%)   25/62 (40%)         23/50 (46%)   16/50 (32%)   23/60 (38%)    |
| Overall Incidence               Total 55/164 (33.54%) Mean 33.06%  SD 6.32%     Total 62/160 (38.75%)  Mean 38.78%  SD 7.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         29/52 (56%)   31/50 (62%)   45/62 (73%)         36/50 (72%)   32/50 (64%)   46/60 (77%)    |
| Overall Incidence               Total 105/164 (64.02%)Mean 63.45%  SD 8.5%      Total 114/160 (71.25%) Mean 70.89%  SD 6.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/52 (2%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/52 (8%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence               Total 5/164 (3.05%)   Mean 3.1%    SD 4.06%     Total 1/160 (0.63%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/52 (8%)     0/50 (0%)     1/62 (2%)           1/50 (2%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence               Total 5/164 (3.05%)   Mean 3.1%    SD 4.06%     Total 2/160 (1.25%)    Mean 1.22%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/52 (2%)     1/50 (2%)     2/62 (3%)           2/50 (4%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence               Total 4/164 (2.44%)   Mean 2.38%   SD 0.73%     Total 3/160 (1.88%)    Mean 1.89%   SD 2.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     5/52 (10%)    3/50 (6%)     6/62 (10%)         15/50 (30%)    8/50 (16%)   11/60 (18%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 14/164 (8.54%)  Mean 8.43%   SD 2.11%     Total 34/160 (21.25%)  Mean 21.44%  SD 7.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 414
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/52 (0%)     2/48 (4%)     1/62 (2%)           0/50 (0%)     2/50 (4%)     0/59 (0%)     |
| Overall Incidence               Total 3/162 (1.85%)   Mean 1.93%   SD 2.1%      Total 2/159 (1.26%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/51 (0%)     0/46 (0%)     1/61 (2%)           0/49 (0%)     0/46 (0%)     1/59 (2%)     |
| Overall Incidence               Total 1/158 (0.63%)   Mean 0.55%   SD 0.95%     Total 1/154 (0.65%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/51 (0%)     0/46 (0%)     0/61 (0%)           0/49 (0%)     0/46 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/158 (0%)      Mean 0%      SD 0%        Total 0/154 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/51 (0%)     0/46 (0%)     0/61 (0%)           0/49 (0%)     0/46 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/158 (0%)      Mean 0%      SD 0%        Total 0/154 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/51 (0%)     0/46 (0%)     1/61 (2%)           0/49 (0%)     0/46 (0%)     1/59 (2%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/158 (0.63%)   Mean 0.55%   SD 0.95%     Total 1/154 (0.65%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 415
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/52 (2%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 1/163 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 416
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 417
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/47 (0%)     0/48 (0%)     0/57 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
| Overall Incidence               Total 0/152 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/52 (2%)     0/50 (0%)     2/62 (3%)           2/50 (4%)     2/50 (4%)     3/60 (5%)     |
| Overall Incidence               Total 3/164 (1.83%)   Mean 1.72%   SD 1.62%     Total 7/160 (4.38%)    Mean 4.33%   SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/52 (0%)     1/50 (2%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.67%   SD 1.15%     Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 1/52 (2%)     1/50 (2%)     2/62 (3%)           2/50 (4%)     3/50 (6%)     3/60 (5%)     |
| Overall Incidence               Total 4/164 (2.44%)   Mean 2.38%   SD 0.73%     Total 8/160 (5%)       Mean 5%      SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 418
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.54%   SD 0.93%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 419
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.54%   SD 0.93%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.54%   SD 0.93%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/52 (2%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 2/164 (1.22%)   Mean 1.18%   SD 1.03%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/52 (0%)     1/50 (2%)     0/62 (0%)           0/49 (0%)     1/49 (2%)     0/59 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.67%   SD 1.15%     Total 1/157 (0.64%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 420
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/52 (0%)     1/50 (2%)     0/62 (0%)           0/49 (0%)     1/49 (2%)     0/59 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.67%   SD 1.15%     Total 1/157 (0.64%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/52 (0%)     1/50 (2%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 2/164 (1.22%)   Mean 1.2%    SD 1.06%     Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/52 (0%)     1/50 (2%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 2/164 (1.22%)   Mean 1.2%    SD 1.06%     Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 421
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/52 (6%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 4/164 (2.44%)   Mean 2.46%   SD 2.98%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/52 (0%)     0/50 (0%)     2/62 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 2/164 (1.22%)   Mean 1.08%   SD 1.86%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              11/52 (21%)   16/50 (32%)   25/62 (40%)          6/50 (12%)    3/50 (6%)    17/60 (28%)    |
| Overall Incidence               Total 52/164 (31.71%) Mean 31.16%  SD 9.61%     Total 26/160 (16.25%)  Mean 15.44%  SD 11.56%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             4/52 (8%)     8/50 (16%)   10/62 (16%)          1/50 (2%)     1/50 (2%)     6/60 (10%)    |
| Overall Incidence               Total 22/164 (13.41%) Mean 13.27%  SD 4.83%     Total 8/160 (5%)       Mean 4.67%   SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          4/52 (8%)     8/50 (16%)   12/62 (19%)          1/50 (2%)     1/50 (2%)     6/60 (10%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 24/164 (14.63%) Mean 14.35%  SD 6%        Total 8/160 (5%)       Mean 4.67%   SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         13/52 (25%)   18/50 (36%)   31/62 (50%)          7/50 (14%)    4/50 (8%)    22/60 (37%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 62/164 (37.8%)  Mean 37%     SD 12.53%    Total 33/160 (20.63%)  Mean 19.56%  SD 15.12%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           13/52 (25%)   18/50 (36%)   31/62 (50%)          7/50 (14%)    4/50 (8%)    22/60 (37%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 62/164 (37.8%)  Mean 37%     SD 12.53%    Total 33/160 (20.63%)  Mean 19.56%  SD 15.12%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 422
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         7/52 (13%)    9/50 (18%)   11/62 (18%)          4/50 (8%)     6/50 (12%)    1/59 (2%)     |
| Overall Incidence               Total 27/164 (16.46%) Mean 16.4%   SD 2.55%     Total 11/159 (6.92%)   Mean 7.23%   SD 5.2%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/52 (2%)     2/50 (4%)     4/62 (6%)           3/50 (6%)     2/50 (4%)     2/59 (3%)     |
| Overall Incidence               Total 7/164 (4.27%)   Mean 4.12%   SD 2.27%     Total 7/159 (4.4%)     Mean 4.46%   SD 1.37%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    8/52 (15%)   11/50 (22%)   14/62 (23%)          7/50 (14%)    8/50 (16%)    2/59 (3%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 33/164 (20.12%) Mean 19.99%  SD 4%        Total 17/159 (10.69%)  Mean 11.13%  SD 6.78%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 423
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 424
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 2/160 (1.25%)    Mean 1.22%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 2/160 (1.25%)    Mean 1.22%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 425
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/156 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/156 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/156 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     1/49 (2%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
| Overall Incidence               Total 1/163 (0.61%)   Mean 0.68%   SD 1.18%     Total 0/156 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 426
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)     0/49 (0%)     1/59 (2%)     |
| Overall Incidence                                                               Total 1/157 (0.64%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     0/49 (0%)     1/59 (2%)     |
| Overall Incidence                                                               Total 1/157 (0.64%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     0/49 (0%)     1/59 (2%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/157 (0.64%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 427
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   1/49 (2%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 1/157 (0.64%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence                                                               Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 428
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/36 (0%)     0/43 (0%)     0/50 (0%)           0/36 (0%)     0/40 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/129 (0%)      Mean 0%      SD 0%        Total 0/125 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/46 (0%)     0/48 (0%)     1/59 (2%)           3/48 (6%)     5/46 (11%)    9/55 (16%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 1/153 (0.65%)   Mean 0.56%   SD 0.98%     Total 17/149 (11.41%)  Mean 11.16%  SD 5.06%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/153 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/46 (0%)     0/48 (0%)     1/59 (2%)           3/48 (6%)     5/46 (11%)    9/55 (16%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 1/153 (0.65%)   Mean 0.56%   SD 0.98%     Total 17/149 (11.41%)  Mean 11.16%  SD 5.06%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 429
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
| Overall Incidence               Total 0/153 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
| Overall Incidence               Total 0/153 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
| Overall Incidence               Total 0/153 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/158 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/158 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/158 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 430
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 431
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 432
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.64%   SD 1.11%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 433
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     2/50 (4%)     2/60 (3%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 6/160 (3.75%)    Mean 3.78%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 2/160 (1.25%)    Mean 1.22%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     2/50 (4%)     2/60 (3%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 6/160 (3.75%)    Mean 3.78%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     1/50 (2%)     1/60 (2%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 4/160 (2.5%)     Mean 2.56%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 434
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/52 (2%)     0/49 (0%)     0/62 (0%)           1/49 (2%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 1/163 (0.61%)   Mean 0.64%   SD 1.11%     Total 1/157 (0.64%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/52 (4%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 2/163 (1.23%)   Mean 1.28%   SD 2.22%     Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/157 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 435
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/52 (6%)     1/50 (2%)     3/62 (5%)           0/50 (0%)     1/50 (2%)     3/60 (5%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 7/164 (4.27%)   Mean 4.2%    SD 1.96%     Total 4/160 (2.5%)     Mean 2.33%   SD 2.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/52 (6%)     1/50 (2%)     3/62 (5%)           0/50 (0%)     1/50 (2%)     3/60 (5%)     |
| Overall Incidence               Total 7/164 (4.27%)   Mean 4.2%    SD 1.96%     Total 4/160 (2.5%)     Mean 2.33%   SD 2.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.54%   SD 0.93%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.54%   SD 0.93%     Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/52 (0%)     1/50 (2%)     0/62 (0%)                                                     |
| Overall Incidence               Total 1/164 (0.61%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 436
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     1/59 (2%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 1/147 (0.68%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     4/50 (8%)     4/60 (7%)     |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 8/159 (5.03%)    Mean 4.89%   SD 4.29%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.54%   SD 0.93%     Total 0/159 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/48 (0%)     1/62 (2%)           0/49 (0%)     4/50 (8%)     4/60 (7%)     |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.2%    SD 1.06%     Total 8/159 (5.03%)    Mean 4.89%   SD 4.29%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 437
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 438
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/163 (0%)      Mean 0%      SD 0%        Total 0/158 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence                                                               Total 1/160 (0.63%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
| Overall Incidence                                                               Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 439
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 1/160 (0.63%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     1/60 (2%)     |
| Overall Incidence                                                               Total 1/160 (0.63%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     1/50 (2%)     1/60 (2%)     |
| Overall Incidence                                                               Total 2/160 (1.25%)    Mean 1.22%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/164 (0%)      Mean 0%      SD 0%        Total 0/160 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 441
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       31/50 (62%)   33/50 (66%)                       19/49 (39%)   14/50 (28%)                  |
| Overall Incidence               Total 64/100 (64%)    Mean 64%     SD 2.83%     Total 33/99 (33.33%)   Mean 33.39%  SD 7.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   17/50 (34%)                       22/49 (45%)   21/50 (42%)                  |
| Overall Incidence               Total 36/100 (36%)    Mean 36%     SD 2.83%     Total 43/99 (43.43%)   Mean 43.45%  SD 2.05%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         41/50 (82%)   38/50 (76%)                       34/49 (69%)   31/50 (62%)                  |
| Overall Incidence               Total 79/100 (79%)    Mean 79%     SD 4.24%     Total 65/99 (65.66%)   Mean 65.69%  SD 5.22%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         2/49 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     2/50 (4%)                         3/49 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 4/99 (4.04%)     Mean 4.06%   SD 2.92%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)     2/50 (4%)                         4/49 (8%)     1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 5/99 (5.05%)     Mean 5.08%   SD 4.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         2/49 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)                        12/49 (24%)    9/50 (18%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 21/99 (21.21%)   Mean 21.24%  SD 4.59%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 442
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     1/50 (2%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.04%   SD 1.47%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/48 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/48 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/48 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/48 (2%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 443
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 444
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 445
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/46 (0%)     0/43 (0%)                         0/44 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/50 (8%)     4/50 (8%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 5/50 (10%)    4/50 (8%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 1.41%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 446
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         1/49 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 447
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         1/49 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     1/50 (2%)                         1/48 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/98 (1.02%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 448
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)                         1/48 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/98 (1.02%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 449
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              18/50 (36%)   25/50 (50%)                        6/49 (12%)    7/50 (14%)                  |
| Overall Incidence               Total 43/100 (43%)    Mean 43%     SD 9.9%      Total 13/99 (13.13%)   Mean 13.12%  SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   12/50 (24%)                        5/49 (10%)    7/50 (14%)                  |
| Overall Incidence               Total 22/100 (22%)    Mean 22%     SD 2.83%     Total 12/99 (12.12%)   Mean 12.1%   SD 2.68%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   12/50 (24%)                        5/49 (10%)    7/50 (14%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 22/100 (22%)    Mean 22%     SD 2.83%     Total 12/99 (12.12%)   Mean 12.1%   SD 2.68%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         24/50 (48%)   30/50 (60%)                        9/49 (18%)   13/50 (26%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 54/100 (54%)    Mean 54%     SD 8.49%     Total 22/99 (22.22%)   Mean 22.18%  SD 5.4%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           24/50 (48%)   30/50 (60%)                        9/49 (18%)   13/50 (26%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 54/100 (54%)    Mean 54%     SD 8.49%     Total 22/99 (22.22%)   Mean 22.18%  SD 5.4%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 450
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        14/50 (28%)   11/50 (22%)                        1/48 (2%)     4/50 (8%)                   |
| Overall Incidence               Total 25/100 (25%)    Mean 25%     SD 4.24%     Total 5/98 (5.1%)      Mean 5.04%   SD 4.18%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     4/50 (8%)                         0/48 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 0%        Total 1/98 (1.02%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)   14/50 (28%)                        1/48 (2%)     5/50 (10%)                  |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 30/100 (30%)    Mean 30%     SD 2.83%     Total 6/98 (6.12%)     Mean 6.04%   SD 5.6%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 451
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 452
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 453
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 454
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/46 (2%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 2/96 (2.08%)     Mean 2.09%   SD 0.12%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/46 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/46 (0%)     1/50 (2%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 455
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         1/46 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/46 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 456
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/39 (0%)     0/38 (0%)                         0/39 (0%)     0/33 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/72 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/50 (0%)                         7/48 (15%)    0/46 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 7/94 (7.45%)     Mean 7.29%   SD 10.31%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/50 (0%)                         7/48 (15%)    0/46 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 7/94 (7.45%)     Mean 7.29%   SD 10.31%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 457
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/50 (0%)                         1/48 (2%)     0/46 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/94 (1.06%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/50 (0%)                         1/48 (2%)     0/46 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/94 (1.06%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 458
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 459
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 460
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 461
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      2/50 (4%)     1/50 (2%)                         0/49 (0%)     0/50 (0%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)                         0/49 (0%)     0/50 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              2/50 (4%)     1/50 (2%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 462
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)                         2/48 (4%)     1/49 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/97 (3.09%)     Mean 3.1%    SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 463
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     2/50 (4%)                         1/49 (2%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     2/50 (4%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 464
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/38 (0%)     0/39 (0%)                         0/47 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/50 (2%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 465
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/48 (0%)     0/50 (0%)                         0/43 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 466
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/48 (0%)     0/50 (0%)                         0/43 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)                         0/43 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/48 (0%)     0/50 (0%)                         0/43 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/48 (0%)     0/50 (0%)                         0/43 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/49 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/49 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/49 (4%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 3/99 (3.03%)     Mean 3.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 467
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/49 (4%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 3/99 (3.03%)     Mean 3.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 469
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       36/51 (71%)                                     25/50 (50%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    16/51 (31%)                                     22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/51 (88%)                                     35/50 (70%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/51 (6%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/51 (6%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/51 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/51 (16%)                                     15/50 (30%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 470
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/48 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/48 (0%)                                       1/49 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 471
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 472
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/51 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 473
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/51 (10%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/51 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/51 (12%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 474
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 475
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 476
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 477
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/51 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              24/51 (47%)                                     13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             5/51 (10%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          5/51 (10%)                                      4/50 (8%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/51 (53%)                                     16/50 (32%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/51 (53%)                                     16/50 (32%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 478
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        14/51 (27%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/51 (29%)                                      3/50 (6%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 479
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 480
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/51 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 481
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/51 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/51 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/51 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/51 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 482
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/51 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 483
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 484
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/35 (0%)                                       0/29 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/47 (2%)                                       9/48 (19%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       0/48 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/47 (2%)                                       9/48 (19%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 485
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 486
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/51 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/51 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 487
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/51 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/51 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/51 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 488
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/51 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/51 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/51 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/51 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 489
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/51 (2%)                                       3/50 (6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/51 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/51 (0%)                                       3/50 (6%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/51 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/51 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 490
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 491
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/51 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/51 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 492
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/39 (0%)                                       0/43 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/51 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/51 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 493
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/51 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 494
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 495
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: E.G. & G. MASON                           Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/51 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 497
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       16/50 (32%)                                     20/50 (40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)                                     17/50 (34%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         27/50 (54%)                                     31/50 (62%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                     10/50 (20%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma       10/50 (20%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       1/50 (2%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)                                       6/50 (12%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 498
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              8/50 (16%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                       0/0 (0%)                                       0/38 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant           0/0 (0%)                                       0/38 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)                                       4/50 (8%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 499
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 500
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 501
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              1/50 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 502
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 503
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 504
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 505
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             4/50 (8%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          4/50 (8%)                                       4/50 (8%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          9/50 (18%)                                      7/50 (14%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            9/50 (18%)                                      7/50 (14%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 506
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         5/50 (10%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    8/50 (16%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 507
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 508
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 509
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 510
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 511
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 512
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       6/49 (12%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/49 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       6/49 (12%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 513
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 514
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 515
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 516
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 517
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 518
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      6/50 (12%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 519
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      1/29 (3%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 520
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/29 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 521
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 522
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 523
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: HAZLETON                                  Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 525
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       20/50 (40%)   24/50 (48%)                       20/50 (40%)   27/51 (53%)                  |
| Overall Incidence               Total 44/100 (44%)    Mean 44%     SD 5.66%     Total 47/101 (46.53%)  Mean 46.47%  SD 9.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    21/50 (42%)   16/50 (32%)                       13/50 (26%)   17/51 (33%)                  |
| Overall Incidence               Total 37/100 (37%)    Mean 37%     SD 7.07%     Total 30/101 (29.7%)   Mean 29.67%  SD 5.19%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         35/50 (70%)   33/50 (66%)                       29/50 (58%)   37/51 (73%)                  |
| Overall Incidence               Total 68/100 (68%)    Mean 68%     SD 2.83%     Total 66/101 (65.35%)  Mean 65.27%  SD 10.29%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     1/50 (2%)                         0/50 (0%)     2/51 (4%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 2/101 (1.98%)    Mean 1.96%   SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     3/50 (6%)                         0/50 (0%)     3/51 (6%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 3/101 (2.97%)    Mean 2.94%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     2/51 (4%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/101 (1.98%)    Mean 1.96%   SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     1/50 (2%)                         3/50 (6%)     7/51 (14%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 10/101 (9.9%)    Mean 9.86%   SD 5.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 526
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/47 (2%)     0/49 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/96 (1.04%)    Mean 1.06%   SD 1.5%      Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/50 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/47 (0%)     0/49 (0%)                         0/47 (0%)     0/47 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 527
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 528
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 529
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/33 (0%)     0/41 (0%)                         0/44 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/74 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/50 (2%)     4/50 (8%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 4.24%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)     4/50 (8%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 4.24%     Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 530
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 531
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)     2/50 (4%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 2/99 (2.02%)    Mean 2%      SD 2.83%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 532
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)     2/50 (4%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 2/99 (2.02%)    Mean 2%      SD 2.83%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 533
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              12/50 (24%)   14/50 (28%)                        6/50 (12%)    6/51 (12%)                  |
| Overall Incidence               Total 26/100 (26%)    Mean 26%     SD 2.83%     Total 12/101 (11.88%)  Mean 11.88%  SD 0.17%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            17/50 (34%)   12/50 (24%)                        7/50 (14%)    4/51 (8%)                   |
| Overall Incidence               Total 29/100 (29%)    Mean 29%     SD 7.07%     Total 11/101 (10.89%)  Mean 10.92%  SD 4.35%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         17/50 (34%)   12/50 (24%)                        7/50 (14%)    4/51 (8%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 29/100 (29%)    Mean 29%     SD 7.07%     Total 11/101 (10.89%)  Mean 10.92%  SD 4.35%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/50 (54%)   24/50 (48%)                       13/50 (26%)   10/51 (20%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 51/100 (51%)    Mean 51%     SD 4.24%     Total 23/101 (22.77%)  Mean 22.8%   SD 4.52%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/50 (54%)   24/50 (48%)                       13/50 (26%)   10/51 (20%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 51/100 (51%)    Mean 51%     SD 4.24%     Total 23/101 (22.77%)  Mean 22.8%   SD 4.52%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 534
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         5/50 (10%)    7/50 (14%)                        4/50 (8%)     4/51 (8%)                   |
| Overall Incidence               Total 12/100 (12%)    Mean 12%     SD 2.83%     Total 8/101 (7.92%)    Mean 7.92%   SD 0.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     1/50 (2%)                         0/50 (0%)     2/51 (4%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 2/101 (1.98%)    Mean 1.96%   SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    7/50 (14%)    8/50 (16%)                        4/50 (8%)     6/51 (12%)                  |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 15/100 (15%)    Mean 15%     SD 1.41%     Total 10/101 (9.9%)    Mean 9.88%   SD 2.66%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 535
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 536
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 537
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 538
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          2/49 (4%)     1/49 (2%)                   |
| Overall Incidence                                                               Total 3/98 (3.06%)     Mean 3.06%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 1/98 (1.02%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/49 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/98 (1.02%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 539
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 540
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/22 (0%)     0/29 (0%)                         0/26 (0%)     0/21 (0%)                   |
| Overall Incidence               Total 0/51 (0%)       Mean 0%      SD 0%        Total 0/47 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)     0/47 (0%)                         4/48 (8%)    12/48 (25%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 16/96 (16.67%)   Mean 16.67%  SD 11.79%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)     0/47 (0%)                         0/48 (0%)     0/48 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)     0/47 (0%)                         4/48 (8%)    12/48 (25%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 16/96 (16.67%)   Mean 16.67%  SD 11.79%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 541
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/44 (0%)     0/47 (0%)                         0/48 (0%)     2/48 (4%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 2/96 (2.08%)     Mean 2.08%   SD 2.95%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/44 (0%)     0/47 (0%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/44 (0%)     0/47 (0%)                         0/48 (0%)     2/48 (4%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 2/96 (2.08%)     Mean 2.08%   SD 2.95%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 542
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 543
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 544
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 545
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 546
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/51 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 547
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1.02%   SD 1.44%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 548
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/37 (0%)     0/45 (0%)                         0/42 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/82 (0%)       Mean 0%      SD 0%        Total 0/89 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/50 (6%)     1/50 (2%)                         5/50 (10%)    4/51 (8%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 9/101 (8.91%)    Mean 8.92%   SD 1.53%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 3/50 (6%)     1/50 (2%)                         5/50 (10%)    4/51 (8%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 9/101 (8.91%)    Mean 8.92%   SD 1.53%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 549
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/48 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 550
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/48 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/48 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/48 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/50 (2%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     1/51 (2%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       1/50 (2%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/50 (4%)     3/51 (6%)                   |
| Overall Incidence                                                               Total 5/101 (4.95%)    Mean 4.94%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 551
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: I. I. T. RESEARCH INSTITUTE               Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/51 (2%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 0.98%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)     4/51 (8%)                   |
| Overall Incidence                                                               Total 6/101 (5.94%)    Mean 5.92%   SD 2.72%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       1/50 (2%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 1/101 (0.99%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/51 (0%)                   |
| Overall Incidence                                                               Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/101 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 553
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       18/55 (33%)   27/59 (46%)   21/60 (35%)         20/60 (33%)   27/58 (47%)   27/60 (45%)    |
| Overall Incidence               Total 66/174 (37.93%) Mean 37.83%  SD 6.96%     Total 74/178 (41.57%)  Mean 41.63%  SD 7.23%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    14/55 (25%)   20/59 (34%)   20/60 (33%)         30/60 (50%)   26/58 (45%)   26/60 (43%)    |
| Overall Incidence               Total 54/174 (31.03%) Mean 30.9%   SD 4.72%     Total 82/178 (46.07%)  Mean 46.05%  SD 3.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         28/55 (51%)   39/59 (66%)   37/60 (62%)         36/60 (60%)   42/58 (72%)   41/60 (68%)    |
| Overall Incidence               Total 104/174 (59.77%)Mean 59.56%  SD 7.81%     Total 119/178 (66.85%) Mean 66.92%  SD 6.33%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/55 (4%)     1/59 (2%)     2/60 (3%)           3/60 (5%)     3/58 (5%)     1/60 (2%)     |
| Overall Incidence               Total 5/174 (2.87%)   Mean 2.89%   SD 1.04%     Total 7/178 (3.93%)    Mean 3.95%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/55 (4%)     2/59 (3%)     2/60 (3%)           3/60 (5%)     4/58 (7%)     1/60 (2%)     |
| Overall Incidence               Total 6/174 (3.45%)   Mean 3.45%   SD 0.16%     Total 8/178 (4.49%)    Mean 4.52%   SD 2.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/55 (0%)     0/59 (0%)     1/60 (2%)           2/60 (3%)     2/58 (3%)     1/60 (2%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.96%     Total 5/178 (2.81%)    Mean 2.82%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/55 (4%)     1/59 (2%)     2/60 (3%)          13/60 (22%)    5/58 (9%)     7/60 (12%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 5/174 (2.87%)   Mean 2.89%   SD 1.04%     Total 25/178 (14.04%)  Mean 13.98%  SD 6.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 554
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              4/55 (7%)     2/59 (3%)     1/60 (2%)           0/60 (0%)     1/58 (2%)     1/59 (2%)     |
| Overall Incidence               Total 7/174 (4.02%)   Mean 4.11%   SD 2.87%     Total 2/177 (1.13%)    Mean 1.14%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/55 (0%)     0/58 (0%)     0/60 (0%)           1/60 (2%)     1/58 (2%)     1/59 (2%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 3/177 (1.69%)    Mean 1.7%    SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/55 (0%)     1/58 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 1/173 (0.58%)   Mean 0.57%   SD 1%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/55 (0%)     0/58 (0%)     0/60 (0%)           2/60 (3%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 2/177 (1.13%)    Mean 1.11%   SD 1.92%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/55 (0%)     1/58 (2%)     0/60 (0%)           3/60 (5%)     1/58 (2%)     1/59 (2%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/173 (0.58%)   Mean 0.57%   SD 1%        Total 5/177 (2.82%)    Mean 2.81%   SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 555
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/57 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     1/60 (2%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.96%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 556
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     1/60 (2%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.96%     Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/54 (0%)     1/59 (2%)     0/60 (0%)                                                     |
| Overall Incidence               Total 1/173 (0.58%)   Mean 0.56%   SD 0.98%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/54 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 557
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/54 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              1/54 (2%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 1/173 (0.58%)   Mean 0.62%   SD 1.07%                                                      |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/56 (0%)     0/55 (0%)           0/57 (0%)     0/53 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/156 (0%)      Mean 0%      SD 0%        Total 0/169 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 558
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 559
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/52 (0%)     1/59 (2%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     2/59 (3%)     |
| Overall Incidence               Total 1/171 (0.58%)   Mean 0.56%   SD 0.98%     Total 2/176 (1.14%)    Mean 1.13%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 560
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/52 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     1/58 (2%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 1/176 (0.57%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/52 (0%)     1/59 (2%)     0/60 (0%)           0/59 (0%)     1/58 (2%)     2/59 (3%)     |
| Overall Incidence               Total 1/171 (0.58%)   Mean 0.56%   SD 0.98%     Total 3/176 (1.7%)     Mean 1.7%    SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 561
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/55 (2%)     0/59 (0%)     1/60 (2%)           0/60 (0%)     2/58 (3%)     0/60 (0%)     |
| Overall Incidence               Total 2/174 (1.15%)   Mean 1.16%   SD 1.01%     Total 2/178 (1.12%)    Mean 1.15%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               8/55 (15%)   13/59 (22%)   17/60 (28%)          6/60 (10%)   13/58 (22%)   13/60 (22%)    |
| Overall Incidence               Total 38/174 (21.84%) Mean 21.64%  SD 6.9%      Total 32/178 (17.98%)  Mean 18.03%  SD 6.96%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             6/55 (11%)   10/59 (17%)   11/60 (18%)          8/60 (13%)   11/58 (19%)    7/60 (12%)    |
| Overall Incidence               Total 27/174 (15.52%) Mean 15.4%   SD 3.95%     Total 26/178 (14.61%)  Mean 14.66%  SD 3.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          6/55 (11%)   10/59 (17%)   11/60 (18%)          8/60 (13%)   11/58 (19%)    7/60 (12%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 27/174 (15.52%) Mean 15.4%   SD 3.95%     Total 26/178 (14.61%)  Mean 14.66%  SD 3.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         12/55 (22%)   23/59 (39%)   26/60 (43%)         14/60 (23%)   20/58 (34%)   18/60 (30%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 61/174 (35.06%) Mean 34.71%  SD 11.38%    Total 52/178 (29.21%)  Mean 29.27%  SD 5.61%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           12/55 (22%)   23/59 (39%)   26/60 (43%)         14/60 (23%)   20/58 (34%)   18/60 (30%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 61/174 (35.06%) Mean 34.71%  SD 11.38%    Total 52/178 (29.21%)  Mean 29.27%  SD 5.61%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 562
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         7/55 (13%)    6/59 (10%)    5/60 (8%)           2/60 (3%)     3/58 (5%)     3/60 (5%)     |
| Overall Incidence               Total 18/174 (10.34%) Mean 10.41%  SD 2.21%     Total 8/178 (4.49%)    Mean 4.5%    SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/55 (7%)     7/59 (12%)    9/60 (15%)          4/60 (7%)     7/58 (12%)    4/60 (7%)     |
| Overall Incidence               Total 20/174 (11.49%) Mean 11.38%  SD 3.89%     Total 15/178 (8.43%)   Mean 8.47%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    9/55 (16%)   13/59 (22%)   13/60 (22%)          6/60 (10%)    9/58 (16%)    7/60 (12%)    |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 35/174 (20.11%) Mean 20.02%  SD 3.17%     Total 22/178 (12.36%)  Mean 12.39%  SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 563
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 2/178 (1.12%)    Mean 1.13%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 564
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           2/60 (3%)     1/58 (2%)     2/60 (3%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 5/178 (2.81%)    Mean 2.8%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           2/60 (3%)     1/58 (2%)     2/60 (3%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 5/178 (2.81%)    Mean 2.8%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/55 (0%)     0/59 (0%)     0/60 (0%)           2/60 (3%)     1/58 (2%)     2/60 (3%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 5/178 (2.81%)    Mean 2.8%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 565
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               1/55 (2%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.61%   SD 1.05%     Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 566
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/57 (2%)     2/58 (3%)     2/58 (3%)     |
| Overall Incidence                                                               Total 5/173 (2.89%)    Mean 2.88%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/57 (0%)     0/58 (0%)     1/58 (2%)     |
| Overall Incidence                                                               Total 1/173 (0.58%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/57 (0%)     0/58 (0%)     1/58 (2%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/173 (0.58%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 567
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/57 (2%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 1/173 (0.58%)    Mean 0.58%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/57 (2%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 1/173 (0.58%)    Mean 0.58%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/57 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence                                                               Total 0/173 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 568
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/52 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/171 (0%)      Mean 0%      SD 0%        Total 0/177 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/36 (0%)     0/54 (0%)     0/48 (0%)           0/49 (0%)     0/52 (0%)     0/40 (0%)     |
| Overall Incidence               Total 0/138 (0%)      Mean 0%      SD 0%        Total 0/141 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/54 (0%)     0/56 (0%)     0/52 (0%)           6/59 (10%)    8/58 (14%)    8/58 (14%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 22/175 (12.57%)  Mean 12.59%  SD 2.09%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/54 (0%)     0/56 (0%)     0/52 (0%)           1/59 (2%)     0/58 (0%)     0/58 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 1/175 (0.57%)    Mean 0.56%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/54 (0%)     0/56 (0%)     0/52 (0%)           7/59 (12%)    8/58 (14%)    8/58 (14%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 23/175 (13.14%)  Mean 13.15%  SD 1.11%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 569
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/54 (0%)     0/56 (0%)     0/52 (0%)           0/59 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/54 (0%)     0/56 (0%)     0/52 (0%)           0/59 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/54 (0%)     0/56 (0%)     0/52 (0%)           0/59 (0%)     0/58 (0%)     0/58 (0%)     |
| Overall Incidence               Total 0/162 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/51 (0%)     0/59 (0%)     0/59 (0%)                                                     |
| Overall Incidence               Total 0/169 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/51 (0%)     0/59 (0%)     0/59 (0%)                                                     |
| Overall Incidence               Total 0/169 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/51 (0%)     0/59 (0%)     0/59 (0%)                                                     |
| Overall Incidence               Total 0/169 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 570
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 571
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     1/60 (2%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     1/60 (2%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     1/60 (2%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     1/60 (2%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 572
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     1/60 (2%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 573
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     2/58 (3%)     5/60 (8%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 7/178 (3.93%)    Mean 3.93%   SD 4.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     2/58 (3%)     5/60 (8%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 7/178 (3.93%)    Mean 3.93%   SD 4.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/55 (0%)     1/59 (2%)     0/60 (0%)           0/60 (0%)     2/58 (3%)     5/60 (8%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%     Total 7/178 (3.93%)    Mean 3.93%   SD 4.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 574
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/54 (2%)     0/59 (0%)     0/60 (0%)           2/60 (3%)     0/58 (0%)     1/60 (2%)     |
| Overall Incidence               Total 1/173 (0.58%)   Mean 0.62%   SD 1.07%     Total 3/178 (1.69%)    Mean 1.67%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/54 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/173 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 575
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/55 (2%)     0/59 (0%)     0/60 (0%)           2/60 (3%)     1/58 (2%)     0/60 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.61%   SD 1.05%     Total 3/178 (1.69%)    Mean 1.69%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/55 (2%)     0/59 (0%)     0/60 (0%)           1/60 (2%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.61%   SD 1.05%     Total 2/178 (1.12%)    Mean 1.13%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/55 (0%)     1/59 (2%)     0/60 (0%)                                                     |
| Overall Incidence               Total 1/174 (0.57%)   Mean 0.56%   SD 0.98%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)                                                     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 576
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/43 (0%)     0/46 (0%)     0/54 (0%)           0/56 (0%)     0/58 (0%)     0/57 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/176 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/176 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/53 (0%)     0/59 (0%)     0/60 (0%)           0/59 (0%)     0/58 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 0/176 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/53 (4%)     4/59 (7%)     0/60 (0%)           2/59 (3%)     2/58 (3%)     1/59 (2%)     |
| Overall Incidence               Total 6/172 (3.49%)   Mean 3.52%   SD 3.4%      Total 5/176 (2.84%)    Mean 2.84%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/53 (0%)     0/59 (0%)     0/60 (0%)           1/59 (2%)     1/58 (2%)     0/59 (0%)     |
| Overall Incidence               Total 0/172 (0%)      Mean 0%      SD 0%        Total 2/176 (1.14%)    Mean 1.14%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/53 (4%)     4/59 (7%)     0/60 (0%)           3/59 (5%)     3/58 (5%)     1/59 (2%)     |
| Overall Incidence               Total 6/172 (3.49%)   Mean 3.52%   SD 3.4%      Total 7/176 (3.98%)    Mean 3.98%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 577
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/52 (0%)     0/59 (0%)     0/59 (0%)           0/60 (0%)     0/56 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/170 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 578
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/52 (0%)     0/59 (0%)     0/59 (0%)           0/60 (0%)     0/56 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/170 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/52 (0%)     0/59 (0%)     0/59 (0%)           0/60 (0%)     0/56 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/170 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/52 (0%)     1/59 (2%)     0/59 (0%)           0/60 (0%)     0/56 (0%)     0/59 (0%)     |
| Overall Incidence               Total 1/170 (0.59%)   Mean 0.56%   SD 0.98%     Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/52 (0%)     0/59 (0%)     0/59 (0%)           0/60 (0%)     0/56 (0%)     0/59 (0%)     |
| Overall Incidence               Total 0/170 (0%)      Mean 0%      SD 0%        Total 0/175 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/60 (0%)     1/58 (2%)     0/60 (0%)     |
| Overall Incidence                                                               Total 1/178 (0.56%)    Mean 0.57%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/60 (2%)     0/58 (0%)     1/60 (2%)     |
| Overall Incidence                                                               Total 2/178 (1.12%)    Mean 1.11%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/60 (3%)     1/58 (2%)     2/60 (3%)     |
| Overall Incidence                                                               Total 5/178 (2.81%)    Mean 2.8%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 579
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: LOVELACE RESEARCH                         Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/60 (2%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 1/178 (0.56%)    Mean 0.56%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/60 (5%)     1/58 (2%)     2/60 (3%)     |
| Overall Incidence                                                               Total 6/178 (3.37%)    Mean 3.35%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence                                                               Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/55 (0%)     0/59 (0%)     0/60 (0%)           0/60 (0%)     0/58 (0%)     0/60 (0%)     |
| Overall Incidence               Total 0/174 (0%)      Mean 0%      SD 0%        Total 0/178 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 581
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       25/50 (50%)   34/50 (68%)                       20/49 (41%)   26/50 (52%)                  |
| Overall Incidence               Total 59/100 (59%)    Mean 59%     SD 12.73%    Total 46/99 (46.46%)   Mean 46.41%  SD 7.91%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    14/50 (28%)   20/50 (40%)                       14/49 (29%)   15/50 (30%)                  |
| Overall Incidence               Total 34/100 (34%)    Mean 34%     SD 8.49%     Total 29/99 (29.29%)   Mean 29.29%  SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         31/50 (62%)   41/50 (82%)                       29/49 (59%)   34/50 (68%)                  |
| Overall Incidence               Total 72/100 (72%)    Mean 72%     SD 14.14%    Total 63/99 (63.64%)   Mean 63.59%  SD 6.23%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)                         1/49 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     2/50 (4%)                         2/49 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 3/99 (3.03%)     Mean 3.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/50 (0%)                         0/49 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/99 (2.02%)     Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     7/50 (14%)                        7/49 (14%)    7/50 (14%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 7.07%     Total 14/99 (14.14%)   Mean 14.14%  SD 0.2%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 582
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 583
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 584
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 585
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/34 (0%)                         0/47 (0%)     0/43 (0%)                   |
| Overall Incidence               Total 0/79 (0%)       Mean 0%      SD 0%        Total 0/90 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)     3/50 (6%)                         3/49 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 0%        Total 4/99 (4.04%)     Mean 4.06%   SD 2.92%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     3/50 (6%)                         3/49 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 0%        Total 4/99 (4.04%)     Mean 4.06%   SD 2.92%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 586
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 587
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)     2/50 (4%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/99 (2.02%)    Mean 2%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 588
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)     2/50 (4%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/99 (2.02%)    Mean 2%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 589
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              16/50 (32%)   23/50 (46%)                        7/49 (14%)   12/50 (24%)                  |
| Overall Incidence               Total 39/100 (39%)    Mean 39%     SD 9.9%      Total 19/99 (19.19%)   Mean 19.14%  SD 6.87%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             7/50 (14%)   13/50 (26%)                        5/49 (10%)    5/50 (10%)                  |
| Overall Incidence               Total 20/100 (20%)    Mean 20%     SD 8.49%     Total 10/99 (10.1%)    Mean 10.1%   SD 0.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          7/50 (14%)   13/50 (26%)                        5/49 (10%)    5/50 (10%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 20/100 (20%)    Mean 20%     SD 8.49%     Total 10/99 (10.1%)    Mean 10.1%   SD 0.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/50 (42%)   29/50 (58%)                       10/49 (20%)   16/50 (32%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 50/100 (50%)    Mean 50%     SD 11.31%    Total 26/99 (26.26%)   Mean 26.2%   SD 8.2%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           21/50 (42%)   29/50 (58%)                       10/49 (20%)   16/50 (32%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 50/100 (50%)    Mean 50%     SD 11.31%    Total 26/99 (26.26%)   Mean 26.2%   SD 8.2%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 590
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        13/50 (26%)   15/50 (30%)                        5/49 (10%)    1/50 (2%)                   |
| Overall Incidence               Total 28/100 (28%)    Mean 28%     SD 2.83%     Total 6/99 (6.06%)     Mean 6.1%    SD 5.8%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   15/50 (30%)                        5/49 (10%)    2/50 (4%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 29/100 (29%)    Mean 29%     SD 1.41%     Total 7/99 (7.07%)     Mean 7.1%    SD 4.39%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 591
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 592
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 593
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 594
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/47 (0%)     2/49 (4%)                   |
| Overall Incidence                                                               Total 2/96 (2.08%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          2/47 (4%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 2/96 (2.08%)     Mean 2.13%   SD 3.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/47 (0%)     1/49 (2%)                   |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/47 (0%)     1/49 (2%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 595
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/47 (2%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 1/96 (1.04%)     Mean 1.06%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/47 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 596
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/41 (0%)     0/36 (0%)                         0/33 (0%)     0/36 (0%)                   |
| Overall Incidence               Total 0/77 (0%)       Mean 0%      SD 0%        Total 0/69 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/46 (0%)                         2/48 (4%)    11/48 (23%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 13/96 (13.54%)   Mean 13.54%  SD 13.26%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/46 (0%)                         0/48 (0%)     0/48 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/46 (0%)                         2/48 (4%)    11/48 (23%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 13/96 (13.54%)   Mean 13.54%  SD 13.26%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 597
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/49 (0%)     0/46 (0%)                         0/48 (0%)     1/48 (2%)                   |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 1/96 (1.04%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/49 (0%)     1/46 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/95 (1.05%)    Mean 1.09%   SD 1.54%     Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     1/46 (2%)                         0/48 (0%)     1/48 (2%)                   |
| Overall Incidence               Total 1/95 (1.05%)    Mean 1.09%   SD 1.54%     Total 1/96 (1.04%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/46 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/46 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/46 (0%)                                                                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 598
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 599
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 600
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 601
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     2/50 (4%)                         0/49 (0%)     1/50 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     2/50 (4%)                         0/49 (0%)     1/50 (2%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     2/50 (4%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 602
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     1/50 (2%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            1/49 (2%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1.02%   SD 1.44%     Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 603
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 604
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/49 (0%)     0/43 (0%)                         0/46 (0%)     0/38 (0%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/84 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     1/49 (2%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.02%   SD 1.39%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     1/49 (2%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.02%   SD 1.39%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 605
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 606
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/49 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/49 (0%)     4/50 (8%)                   |
| Overall Incidence                                                               Total 4/99 (4.04%)     Mean 4%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 607
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: MICROB. ASSOC.                            Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/49 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/49 (2%)     4/50 (8%)                   |
| Overall Incidence                                                               Total 5/99 (5.05%)     Mean 5.02%   SD 4.21%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/49 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 609
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   26/50 (52%)   29/50 (58%)         23/50 (46%)   22/50 (44%)   33/50 (66%)    |
| Overall Incidence               Total 82/150 (54.67%) Mean 54.67%  SD 3.06%     Total 78/150 (52%)     Mean 52%     SD 12.17%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   25/50 (50%)   32/50 (64%)         21/50 (42%)   19/50 (38%)   26/50 (52%)    |
| Overall Incidence               Total 80/150 (53.33%) Mean 53.33%  SD 9.45%     Total 66/150 (44%)     Mean 44%     SD 7.21%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         33/50 (66%)   40/50 (80%)   44/50 (88%)         35/50 (70%)   34/50 (68%)   46/50 (92%)    |
| Overall Incidence               Total 117/150 (78%)   Mean 78%     SD 11.14%    Total 115/150 (76.67%) Mean 76.67%  SD 13.32%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     3/50 (6%)     3/50 (6%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 10/150 (6.67%)  Mean 6.67%   SD 1.15%     Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    4/50 (8%)     3/50 (6%)           1/50 (2%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 12/150 (8%)     Mean 8%      SD 2%        Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)     5/50 (10%)    5/50 (10%)          9/50 (18%)   13/50 (26%)   11/50 (22%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 14/150 (9.33%)  Mean 9.33%   SD 1.15%     Total 33/150 (22%)     Mean 22%     SD 4%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 610
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 5/150 (3.33%)   Mean 3.33%   SD 4.16%     Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 611
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 612
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 613
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/47 (0%)     0/49 (0%)     0/45 (0%)           0/49 (0%)     0/49 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/50 (8%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     6/50 (12%)    |
| Overall Incidence               Total 7/150 (4.67%)   Mean 4.67%   SD 3.06%     Total 11/150 (7.33%)   Mean 7.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)     3/50 (6%)     1/50 (2%)           4/50 (8%)     2/50 (4%)     6/50 (12%)    |
| Overall Incidence               Total 8/150 (5.33%)   Mean 5.33%   SD 3.06%     Total 12/150 (8%)      Mean 8%      SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 614
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 615
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 616
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 617
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 4/150 (2.67%)   Mean 2.67%   SD 2.31%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              19/50 (38%)   13/50 (26%)   21/50 (42%)         13/50 (26%)   12/50 (24%)   20/50 (40%)    |
| Overall Incidence               Total 53/150 (35.33%) Mean 35.33%  SD 8.33%     Total 45/150 (30%)     Mean 30%     SD 8.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   13/50 (26%)   19/50 (38%)          7/50 (14%)    2/50 (4%)    11/50 (22%)    |
| Overall Incidence               Total 42/150 (28%)    Mean 28%     SD 9.17%     Total 20/150 (13.33%)  Mean 13.33%  SD 9.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/50 (26%)   19/50 (38%)          7/50 (14%)    2/50 (4%)    11/50 (22%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 42/150 (28%)    Mean 28%     SD 9.17%     Total 20/150 (13.33%)  Mean 13.33%  SD 9.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/50 (50%)   24/50 (48%)   34/50 (68%)         17/50 (34%)   14/50 (28%)   29/50 (58%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 83/150 (55.33%) Mean 55.33%  SD 11.02%    Total 60/150 (40%)     Mean 40%     SD 15.87%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           25/50 (50%)   24/50 (48%)   34/50 (68%)         17/50 (34%)   14/50 (28%)   29/50 (58%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 83/150 (55.33%) Mean 55.33%  SD 11.02%    Total 60/150 (40%)     Mean 40%     SD 15.87%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 618
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         7/50 (14%)   11/50 (22%)    8/50 (16%)          2/50 (4%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 26/150 (17.33%) Mean 17.33%  SD 4.16%     Total 7/150 (4.67%)    Mean 4.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)    3/50 (6%)     6/50 (12%)          0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 14/150 (9.33%)  Mean 9.33%   SD 3.06%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    9/50 (18%)   14/50 (28%)   13/50 (26%)          2/50 (4%)     3/50 (6%)     4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 36/150 (24%)    Mean 24%     SD 5.29%     Total 9/150 (6%)       Mean 6%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 619
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 620
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 621
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 622
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/146 (0.68%)    Mean 0.71%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/47 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/146 (0.68%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/47 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/146 (0.68%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/47 (0%)     1/49 (2%)     0/50 (0%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/146 (0.68%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 623
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/146 (0.68%)    Mean 0.71%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 624
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/48 (0%)           0/47 (0%)     0/42 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/145 (0%)      Mean 0%      SD 0%        Total 0/138 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     1/44 (2%)     0/49 (0%)           4/48 (8%)     7/49 (14%)    9/49 (18%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 1/141 (0.71%)   Mean 0.76%   SD 1.31%     Total 20/146 (13.7%)   Mean 13.66%  SD 5.05%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/44 (0%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     1/44 (2%)     0/49 (0%)           4/48 (8%)     7/49 (14%)    9/49 (18%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 1/141 (0.71%)   Mean 0.76%   SD 1.31%     Total 20/146 (13.7%)   Mean 13.66%  SD 5.05%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 625
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/44 (0%)     0/49 (0%)           1/48 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 2/146 (1.37%)    Mean 1.37%   SD 1.19%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     1/44 (2%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/141 (0.71%)   Mean 0.76%   SD 1.31%     Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     1/44 (2%)     0/49 (0%)           1/48 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 1/141 (0.71%)   Mean 0.76%   SD 1.31%     Total 2/146 (1.37%)    Mean 1.37%   SD 1.19%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 626
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 627
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 628
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 629
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 630
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      4/50 (8%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/150 (4.67%)   Mean 4.67%   SD 3.06%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 631
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           4/50 (8%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     5/50 (10%)    4/50 (8%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 8/150 (5.33%)   Mean 5.33%   SD 3.06%     Total 12/150 (8%)      Mean 8%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     5/50 (10%)    4/50 (8%)     |
| Overall Incidence               Total 7/150 (4.67%)   Mean 4.67%   SD 2.31%     Total 12/150 (8%)      Mean 8%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 632
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/134 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 633
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 634
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 635
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence                                                               Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 637
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       33/50 (66%)   26/50 (52%)   28/50 (56%)         30/50 (60%)   23/50 (46%)   36/50 (72%)    |
| Overall Incidence               Total 87/150 (58%)    Mean 58%     SD 7.21%     Total 89/150 (59.33%)  Mean 59.33%  SD 13.01%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    28/50 (56%)   30/50 (60%)   28/50 (56%)         26/50 (52%)   23/50 (46%)   32/50 (64%)    |
| Overall Incidence               Total 86/150 (57.33%) Mean 57.33%  SD 2.31%     Total 81/150 (54%)     Mean 54%     SD 9.17%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   40/50 (80%)   41/50 (82%)         41/50 (82%)   35/50 (70%)   44/50 (88%)    |
| Overall Incidence               Total 124/150 (82.67%)Mean 82.67%  SD 3.06%     Total 120/150 (80%)    Mean 80%     SD 9.17%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      7/50 (14%)    3/50 (6%)     5/50 (10%)          1/50 (2%)     0/50 (0%)     5/50 (10%)    |
| Overall Incidence               Total 15/150 (10%)    Mean 10%     SD 4%        Total 6/150 (4%)       Mean 4%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        9/50 (18%)    3/50 (6%)     5/50 (10%)          1/50 (2%)     1/50 (2%)     7/50 (14%)    |
| Overall Incidence               Total 17/150 (11.33%) Mean 11.33%  SD 6.11%     Total 9/150 (6%)       Mean 6%      SD 6.93%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 7/150 (4.67%)    Mean 4.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     7/50 (14%)    2/50 (4%)           5/50 (10%)   13/50 (26%)    8/50 (16%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 10/150 (6.67%)  Mean 6.67%   SD 6.43%     Total 26/150 (17.33%)  Mean 17.33%  SD 8.08%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 638
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              5/50 (10%)    0/50 (0%)     2/49 (4%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/149 (4.7%)    Mean 4.69%   SD 5.03%     Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 1/148 (0.68%)   Mean 0.69%   SD 1.2%      Total 2/149 (1.34%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     1/50 (2%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/148 (0.68%)   Mean 0.67%   SD 1.15%     Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     1/50 (2%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     3/50 (6%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 2/148 (1.35%)   Mean 1.36%   SD 1.18%     Total 3/149 (2.01%)    Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 639
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 640
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 641
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/41 (0%)     0/50 (0%)     0/44 (0%)           0/48 (0%)     0/48 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/135 (0%)      Mean 0%      SD 0%        Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)     3/50 (6%)     3/50 (6%)           4/50 (8%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 9/150 (6%)      Mean 6%      SD 0%        Total 7/150 (4.67%)    Mean 4.67%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     3/50 (6%)     3/50 (6%)           5/50 (10%)    0/50 (0%)     4/50 (8%)     |
| Overall Incidence               Total 9/150 (6%)      Mean 6%      SD 0%        Total 9/150 (6%)       Mean 6%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 642
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 643
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     1/50 (2%)     1/48 (2%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 2/147 (1.36%)    Mean 1.36%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 644
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     1/50 (2%)     1/48 (2%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 2/147 (1.36%)    Mean 1.36%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 645
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      6/50 (12%)    3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 11/150 (7.33%)  Mean 7.33%   SD 4.16%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              25/50 (50%)   16/50 (32%)   19/50 (38%)         20/50 (40%)   11/50 (22%)   19/50 (38%)    |
| Overall Incidence               Total 60/150 (40%)    Mean 40%     SD 9.17%     Total 50/150 (33.33%)  Mean 33.33%  SD 9.87%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            21/50 (42%)   13/50 (26%)   19/50 (38%)         12/50 (24%)   13/50 (26%)   14/50 (28%)    |
| Overall Incidence               Total 53/150 (35.33%) Mean 35.33%  SD 8.33%     Total 39/150 (26%)     Mean 26%     SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/50 (42%)   13/50 (26%)   20/50 (40%)         13/50 (26%)   13/50 (26%)   14/50 (28%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 54/150 (36%)    Mean 36%     SD 8.72%     Total 40/150 (26.67%)  Mean 26.67%  SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         36/50 (72%)   24/50 (48%)   35/50 (70%)         27/50 (54%)   20/50 (40%)   24/50 (48%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 95/150 (63.33%) Mean 63.33%  SD 13.32%    Total 71/150 (47.33%)  Mean 47.33%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           36/50 (72%)   24/50 (48%)   36/50 (72%)         27/50 (54%)   20/50 (40%)   24/50 (48%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 96/150 (64%)    Mean 64%     SD 13.86%    Total 71/150 (47.33%)  Mean 47.33%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 646
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)   10/49 (20%)    6/50 (12%)          3/49 (6%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 28/149 (18.79%) Mean 18.8%   SD 6.16%     Total 8/149 (5.37%)    Mean 5.37%   SD 3.07%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     6/49 (12%)    2/50 (4%)           3/49 (6%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 12/149 (8.05%)  Mean 8.08%   SD 4.12%     Total 5/149 (3.36%)    Mean 3.37%   SD 3.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   16/49 (33%)    8/50 (16%)          6/49 (12%)    1/50 (2%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 38/149 (25.5%)  Mean 25.55%  SD 8.59%     Total 13/149 (8.72%)   Mean 8.75%   SD 5.85%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 647
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 648
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 649
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 650
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          2/50 (4%)     0/49 (0%)     3/50 (6%)     |
| Overall Incidence                                                               Total 5/149 (3.36%)    Mean 3.33%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 651
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/50 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 652
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/46 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/45 (0%)     0/43 (0%)     |
| Overall Incidence               Total 0/144 (0%)      Mean 0%      SD 0%        Total 0/135 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/40 (0%)     0/48 (0%)     0/47 (0%)           2/46 (4%)     7/50 (14%)    8/49 (16%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/135 (0%)      Mean 0%      SD 0%        Total 17/145 (11.72%)  Mean 11.56%  SD 6.35%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/40 (0%)     0/48 (0%)     0/47 (0%)           0/46 (0%)     1/50 (2%)     0/49 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/135 (0%)      Mean 0%      SD 0%        Total 1/145 (0.69%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/40 (0%)     0/48 (0%)     0/47 (0%)           2/46 (4%)     8/50 (16%)    8/49 (16%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/135 (0%)      Mean 0%      SD 0%        Total 18/145 (12.41%)  Mean 12.22%  SD 6.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 653
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/40 (0%)     1/48 (2%)     0/47 (0%)           0/46 (0%)     0/50 (0%)     2/49 (4%)     |
| Overall Incidence               Total 1/135 (0.74%)   Mean 0.69%   SD 1.2%      Total 2/145 (1.38%)    Mean 1.36%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/40 (0%)     0/48 (0%)     0/47 (0%)           0/46 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/135 (0%)      Mean 0%      SD 0%        Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/40 (0%)     1/48 (2%)     0/47 (0%)           0/46 (0%)     0/50 (0%)     2/49 (4%)     |
| Overall Incidence               Total 1/135 (0.74%)   Mean 0.69%   SD 1.2%      Total 2/145 (1.38%)    Mean 1.36%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 654
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 655
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 656
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 657
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 658
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     3/49 (6%)     |
| Overall Incidence               Total 3/148 (2.03%)   Mean 2.03%   SD 2%        Total 4/148 (2.7%)     Mean 2.72%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 659
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/41 (0%)     1/45 (2%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/128 (0.78%)   Mean 0.74%   SD 1.28%     Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 660
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/41 (0%)     0/45 (0%)     0/42 (0%)           0/48 (0%)     0/47 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/128 (0%)      Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     4/50 (8%)     6/50 (12%)          3/49 (6%)     1/50 (2%)     2/49 (4%)     |
| Overall Incidence               Total 12/150 (8%)     Mean 8%      SD 4%        Total 6/148 (4.05%)    Mean 4.07%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     4/50 (8%)     6/50 (12%)          4/49 (8%)     1/50 (2%)     2/49 (4%)     |
| Overall Incidence               Total 12/150 (8%)     Mean 8%      SD 4%        Total 7/148 (4.73%)    Mean 4.75%   SD 3.14%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 661
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 662
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 663
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 665
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)   28/50 (56%)   24/50 (48%)         26/52 (50%)   29/50 (58%)   21/50 (42%)    |
|                                       29/50 (58%)   20/50 (40%)   33/50 (66%)         31/50 (62%)   22/50 (44%)   22/51 (43%)    |
| Overall Incidence               Total 164/300 (54.67%)Mean 54.67%  SD 9.27%     Total 151/303 (49.83%) Mean 49.86%  SD 8.43%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   24/50 (48%)   31/50 (62%)         16/52 (31%)   17/50 (34%)   22/50 (44%)    |
|                                       16/50 (32%)   18/50 (36%)   21/50 (42%)         20/50 (40%)   23/50 (46%)   18/51 (35%)    |
| Overall Incidence               Total 127/300 (42.33%)Mean 42.33%  SD 11.27%    Total 116/303 (38.28%) Mean 38.34%  SD 5.98%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         37/50 (74%)   42/50 (84%)   43/50 (86%)         35/52 (67%)   35/50 (70%)   34/50 (68%)    |
|                                       38/50 (76%)   33/50 (66%)   39/50 (78%)         39/50 (78%)   36/50 (72%)   32/51 (63%)    |
| Overall Incidence               Total 232/300 (77.33%)Mean 77.33%  SD 7.23%     Total 211/303 (69.64%) Mean 69.68%  SD 5.12%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/50 (2%)           1/52 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 1.63%     Total 5/303 (1.65%)    Mean 1.65%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/50 (4%)     2/50 (4%)     3/50 (6%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     6/50 (12%)    7/50 (14%)          1/50 (2%)     4/50 (8%)     2/51 (4%)     |
| Overall Incidence               Total 23/300 (7.67%)  Mean 7.67%   SD 4.27%     Total 8/303 (2.64%)    Mean 2.65%   SD 3%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     2/50 (4%)     4/50 (8%)           1/52 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        4/50 (8%)     6/50 (12%)    9/50 (18%)          3/50 (6%)     4/50 (8%)     2/51 (4%)     |
| Overall Incidence               Total 27/300 (9%)     Mean 9%      SD 5.33%     Total 13/303 (4.29%)   Mean 4.31%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     2/51 (4%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 7/303 (2.31%)    Mean 2.31%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 666
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     2/50 (4%)     5/50 (10%)          5/52 (10%)    8/50 (16%)    9/50 (18%)    |
|      Lymphocytic, Mixed, NOS, or       4/50 (8%)     2/50 (4%)     4/50 (8%)           5/50 (10%)    9/50 (18%)    3/51 (6%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 19/300 (6.33%)  Mean 6.33%   SD 2.66%     Total 39/303 (12.87%)  Mean 12.92%  SD 5.1%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/303 (0.99%)    Mean 0.99%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/303 (0.99%)    Mean 0.99%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/48 (2%)     4/50 (8%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        7/50 (14%)    0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 14/298 (4.7%)   Mean 4.68%   SD 5.31%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/48 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/48 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/48 (0%)     0/50 (0%)      0/0 (0%)           0/51 (0%)     0/50 (0%)      0/0 (0%)     |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/248 (0%)      Mean 0%      SD 0%        Total 0/251 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/51 (2%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 4/301 (1.33%)    Mean 1.33%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 667
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     1/50 (2%)     1/50 (2%)     |
|      Complex, Malignant, NOS           1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/51 (2%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.1%      Total 5/301 (1.66%)    Mean 1.67%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 668
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/303 (0.99%)    Mean 0.99%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/303 (0.99%)    Mean 0.99%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     1/50 (2%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 669
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 670
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/47 (0%)     1/48 (2%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/288 (0.35%)   Mean 0.35%   SD 0.85%     Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)     4/50 (8%)     4/50 (8%)           2/52 (4%)     3/50 (6%)     0/50 (0%)     |
|                                         0/0 (0%)     1/50 (2%)     3/50 (6%)            0/0 (0%)     3/50 (6%)     0/51 (0%)     |
| Overall Incidence               Total 15/250 (6%)     Mean 5%      SD 3.29%     Total 8/253 (3.16%)    Mean 2.64%   SD 3%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     1/50 (2%)     |
|                                         0/0 (0%)     0/50 (0%)     0/50 (0%)            0/0 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.33%   SD 0.82%     Total 2/253 (0.79%)    Mean 0.65%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)     4/50 (8%)     4/50 (8%)           3/52 (6%)     3/50 (6%)     1/50 (2%)     |
|                                         0/0 (0%)     1/50 (2%)     3/50 (6%)            0/0 (0%)     3/50 (6%)     0/51 (0%)     |
| Overall Incidence               Total 16/250 (6.4%)   Mean 5.33%   SD 3.5%      Total 10/253 (3.95%)   Mean 3.29%   SD 2.97%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 671
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 672
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 2.66%     Total 3/303 (0.99%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 673
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 2.53%     Total 4/303 (1.32%)    Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     2/50 (4%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 2.53%     Total 4/303 (1.32%)    Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     0/50 (0%)     0/49 (0%)           1/51 (2%)     3/50 (6%)     0/48 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence               Total 4/298 (1.34%)   Mean 1.34%   SD 1.64%     Total 7/300 (2.33%)    Mean 2.32%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 674
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     0/50 (0%)     0/49 (0%)           1/51 (2%)     3/50 (6%)     0/48 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence               Total 4/298 (1.34%)   Mean 1.34%   SD 1.64%     Total 7/300 (2.33%)    Mean 2.32%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 675
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   1/49 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/49 (2%)     0/50 (0%)     3/50 (6%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     1/50 (2%)     1/51 (2%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 2.75%     Total 3/302 (0.99%)    Mean 0.99%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/49 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              18/49 (37%)   10/50 (20%)    9/50 (18%)         16/51 (31%)    6/50 (12%)    9/50 (18%)    |
|                                       14/50 (28%)   17/50 (34%)   28/50 (56%)         14/50 (28%)   11/50 (22%)    9/51 (18%)    |
| Overall Incidence               Total 96/299 (32.11%) Mean 32.12%  SD 13.84%    Total 65/302 (21.52%)  Mean 21.5%   SD 7.17%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/49 (22%)   12/50 (24%)   20/50 (40%)          5/51 (10%)   10/50 (20%)    4/50 (8%)     |
|                                        7/50 (14%)    8/50 (16%)    8/50 (16%)          5/50 (10%)    4/50 (8%)     8/51 (16%)    |
| Overall Incidence               Total 66/299 (22.07%) Mean 22.07%  SD 9.64%     Total 36/302 (11.92%)  Mean 11.92%  SD 4.87%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/49 (22%)   12/50 (24%)   21/50 (42%)          5/51 (10%)   10/50 (20%)    4/50 (8%)     |
|      Hepatoblastoma                    7/50 (14%)    8/50 (16%)    8/50 (16%)          6/50 (12%)    4/50 (8%)     8/51 (16%)    |
| Overall Incidence               Total 67/299 (22.41%) Mean 22.41%  SD 10.38%    Total 37/302 (12.25%)  Mean 12.25%  SD 4.78%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 676
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/49 (55%)   22/50 (44%)   28/50 (56%)         20/51 (39%)   14/50 (28%)   13/50 (26%)    |
|      Hepatocellular Adenoma           21/50 (42%)   22/50 (44%)   31/50 (62%)         17/50 (34%)   15/50 (30%)   17/51 (33%)    |
| Overall Incidence               Total 151/299 (50.5%) Mean 50.52%  SD 8.25%     Total 96/302 (31.79%)  Mean 31.76%  SD 4.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/49 (55%)   22/50 (44%)   29/50 (58%)         20/51 (39%)   14/50 (28%)   13/50 (26%)    |
|      Hepatocellular Adenoma, or       21/50 (42%)   22/50 (44%)   31/50 (62%)         17/50 (34%)   15/50 (30%)   17/51 (33%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 152/299 (50.84%)Mean 50.85%  SD 8.55%     Total 96/302 (31.79%)  Mean 31.76%  SD 4.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 677
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)    9/50 (18%)    9/50 (18%)          3/52 (6%)     1/50 (2%)     4/50 (8%)     |
|                                        5/50 (10%)    6/50 (12%)   12/50 (24%)          4/50 (8%)     3/50 (6%)     3/51 (6%)     |
| Overall Incidence               Total 53/300 (17.67%) Mean 17.67%  SD 5.85%     Total 18/303 (5.94%)   Mean 5.94%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     5/50 (10%)   10/50 (20%)          2/52 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        1/50 (2%)     1/50 (2%)     3/50 (6%)           2/50 (4%)     0/50 (0%)     2/51 (4%)     |
| Overall Incidence               Total 23/300 (7.67%)  Mean 7.67%   SD 6.74%     Total 8/303 (2.64%)    Mean 2.63%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   14/50 (28%)   18/50 (36%)          5/52 (10%)    1/50 (2%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma      6/50 (12%)    7/50 (14%)   15/50 (30%)          6/50 (12%)    3/50 (6%)     5/51 (10%)    |
| Overall Incidence               Total 75/300 (25%)    Mean 25%     SD 9.7%      Total 26/303 (8.58%)   Mean 8.57%   SD 3.9%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 678
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 679
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 680
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 681
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              2/51 (4%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/294 (1.02%)    Mean 0.99%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 682
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/51 (0%)     0/49 (0%)     1/45 (2%)     |
|                                                                                        1/49 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence                                                               Total 5/294 (1.7%)     Mean 1.71%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/51 (0%)     1/49 (2%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/294 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/51 (0%)     1/49 (2%)     0/45 (0%)     |
|      Malignant, NOS                                                                    0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/294 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 683
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/294 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/51 (0%)     0/49 (0%)     0/45 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/294 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 684
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/47 (0%)     0/42 (0%)     0/44 (0%)           0/44 (0%)     0/48 (0%)     0/44 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/40 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/282 (0%)      Mean 0%      SD 0%        Total 0/272 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     3/48 (6%)     0/40 (0%)           4/50 (8%)     9/48 (19%)    4/46 (9%)     |
|   Adenoma                              0/47 (0%)     0/46 (0%)     1/46 (2%)           7/49 (14%)    7/48 (15%)    5/49 (10%)    |
| Overall Incidence               Total 4/275 (1.45%)   Mean 1.4%    SD 2.53%     Total 36/290 (12.41%)  Mean 12.42%  SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     0/40 (0%)           0/50 (0%)     0/48 (0%)     0/46 (0%)     |
|   Carcinoma                            0/47 (0%)     0/46 (0%)     0/46 (0%)           0/49 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/275 (0%)      Mean 0%      SD 0%        Total 1/290 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 685
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     3/48 (6%)     0/40 (0%)           4/50 (8%)     9/48 (19%)    4/46 (9%)     |
|   Carcinoma or Adenoma                 0/47 (0%)     0/46 (0%)     1/46 (2%)           7/49 (14%)    8/48 (17%)    5/49 (10%)    |
| Overall Incidence               Total 4/275 (1.45%)   Mean 1.4%    SD 2.53%     Total 37/290 (12.76%)  Mean 12.77%  SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/40 (0%)           0/50 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/46 (0%)     0/46 (0%)           1/49 (2%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/275 (0%)      Mean 0%      SD 0%        Total 1/290 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/48 (0%)     0/40 (0%)           0/50 (0%)     0/48 (0%)     1/46 (2%)     |
|                                        0/47 (0%)     0/46 (0%)     0/46 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/275 (0%)      Mean 0%      SD 0%        Total 1/290 (0.34%)    Mean 0.36%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/40 (0%)           0/50 (0%)     0/48 (0%)     1/46 (2%)     |
|                                        0/47 (0%)     0/46 (0%)     0/46 (0%)           1/49 (2%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/275 (0%)      Mean 0%      SD 0%        Total 2/290 (0.69%)    Mean 0.7%    SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 686
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 687
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/303 (0.66%)    Mean 0.65%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           1/52 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/303 (0.66%)    Mean 0.65%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 688
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 2/303 (0.66%)    Mean 0.66%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/303 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 1.51%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 689
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, Squamous Cell          1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, or Keratoacanthoma     1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 690
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/51 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/303 (1.65%)    Mean 1.65%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/303 (0.66%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/51 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/303 (1.65%)    Mean 1.65%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     2/51 (4%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/303 (0.99%)    Mean 0.99%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 691
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3%      SD 3.95%     Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 692
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     3/50 (6%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     2/50 (4%)     |
|      Papilloma Squamous                3/50 (6%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     1/51 (2%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 3.1%      Total 7/303 (2.31%)    Mean 2.33%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     3/50 (6%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     1/51 (2%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 3.1%      Total 6/303 (1.98%)    Mean 1.99%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 693
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     1/45 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 1/282 (0.35%)    Mean 0.37%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 694
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     0/45 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/42 (0%)     0/42 (0%)           0/46 (0%)     1/45 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/44 (0%)           0/47 (0%)     0/50 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/264 (0%)      Mean 0%      SD 0%        Total 1/282 (0.35%)    Mean 0.37%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)     2/50 (4%)     1/50 (2%)           3/51 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        2/49 (4%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence               Total 7/298 (2.35%)   Mean 2.35%   SD 1.52%     Total 8/302 (2.65%)    Mean 2.64%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence               Total 2/298 (0.67%)   Mean 0.67%   SD 1.04%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/49 (2%)     2/50 (4%)     2/50 (4%)           3/51 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        2/49 (4%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     1/51 (2%)     |
| Overall Incidence               Total 9/298 (3.02%)   Mean 3.02%   SD 1.1%      Total 9/302 (2.98%)    Mean 2.97%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 695
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 696
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     1/49 (2%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.34%   SD 0.83%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      1/49 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.34%   SD 0.83%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence                                                               Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence                                                               Total 2/303 (0.66%)    Mean 0.66%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 697
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/51 (2%)     |
| Overall Incidence                                                               Total 1/303 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence                                                               Total 2/303 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/52 (6%)     8/50 (16%)    2/50 (4%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 16/303 (5.28%)   Mean 5.29%   SD 5.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence                                                               Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/52 (6%)     8/50 (16%)    2/50 (4%)     |
|                                                                                        3/50 (6%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence                                                               Total 17/303 (5.61%)   Mean 5.63%   SD 5.57%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence                                                               Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 698
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/51 (0%)     |
| Overall Incidence                                                               Total 1/303 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/303 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 699
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       39/50 (78%)   47/60 (78%)                       26/50 (52%)   38/60 (63%)                  |
| Overall Incidence               Total 86/110 (78.18%) Mean 78.17%  SD 0.24%     Total 64/110 (58.18%)  Mean 57.67%  SD 8.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    22/50 (44%)   41/60 (68%)                       23/50 (46%)   41/60 (68%)                  |
| Overall Incidence               Total 63/110 (57.27%) Mean 56.17%  SD 17.21%    Total 64/110 (58.18%)  Mean 57.17%  SD 15.79%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)   56/60 (93%)                       35/50 (70%)   54/60 (90%)                  |
| Overall Incidence               Total 98/110 (89.09%) Mean 88.67%  SD 6.6%      Total 89/110 (80.91%)  Mean 80%     SD 14.14%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           3/50 (6%)     0/60 (0%)                         3/50 (6%)     0/60 (0%)                   |
| Overall Incidence               Total 3/110 (2.73%)   Mean 3%      SD 4.24%     Total 3/110 (2.73%)    Mean 3%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     4/60 (7%)                         3/50 (6%)     5/60 (8%)                   |
| Overall Incidence               Total 7/110 (6.36%)   Mean 6.33%   SD 0.47%     Total 8/110 (7.27%)    Mean 7.17%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)    4/60 (7%)                         5/50 (10%)    5/60 (8%)                   |
| Overall Incidence               Total 10/110 (9.09%)  Mean 9.33%   SD 3.77%     Total 10/110 (9.09%)   Mean 9.17%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     2/60 (3%)                         0/50 (0%)     3/60 (5%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.67%   SD 2.36%     Total 3/110 (2.73%)    Mean 2.5%    SD 3.54%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     7/60 (12%)                        9/50 (18%)   17/60 (28%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 7/110 (6.36%)   Mean 5.83%   SD 8.25%     Total 26/110 (23.64%)  Mean 23.17%  SD 7.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 700
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/60 (2%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              5/50 (10%)    4/60 (7%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 9/110 (8.18%)   Mean 8.33%   SD 2.36%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/49 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 1.02%   SD 1.44%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/109 (0.92%)   Mean 1.02%   SD 1.44%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 701
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     1/60 (2%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/60 (2%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/60 (0%)                         0/49 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 702
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/60 (0%)                         0/49 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 703
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)     0/55 (0%)                         0/47 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)     8/60 (13%)                        1/50 (2%)     1/60 (2%)                   |
| Overall Incidence               Total 11/110 (10%)    Mean 9.67%   SD 5.19%     Total 2/110 (1.82%)    Mean 1.83%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     2/60 (3%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.67%   SD 2.36%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)    10/60 (17%)                        1/50 (2%)     1/60 (2%)                   |
| Overall Incidence               Total 13/110 (11.82%) Mean 11.33%  SD 7.54%     Total 2/110 (1.82%)    Mean 1.83%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 704
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 705
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     1/60 (2%)                         0/50 (0%)     2/60 (3%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 2/110 (1.82%)    Mean 1.67%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     1/60 (2%)                         0/50 (0%)     2/60 (3%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 2/110 (1.82%)    Mean 1.67%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     1/60 (2%)                         0/50 (0%)     2/60 (3%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 2/110 (1.82%)    Mean 1.67%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/59 (2%)                         0/50 (0%)     1/59 (2%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 0.85%   SD 1.2%      Total 1/109 (0.92%)    Mean 0.85%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 706
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/59 (2%)                         0/50 (0%)     1/59 (2%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 0.85%   SD 1.2%      Total 1/109 (0.92%)    Mean 0.85%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 707
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     1/59 (2%)                         0/50 (0%)     1/59 (2%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 0.85%   SD 1.2%      Total 1/109 (0.92%)    Mean 0.85%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/59 (0%)                         1/50 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     3/59 (5%)                         1/50 (2%)     2/59 (3%)                   |
| Overall Incidence               Total 4/109 (3.67%)   Mean 3.54%   SD 2.18%     Total 3/109 (2.75%)    Mean 2.69%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       1/50 (2%)     2/59 (3%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 3/109 (2.75%)   Mean 2.69%   SD 0.98%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/50 (60%)   40/59 (68%)                       19/50 (38%)   29/59 (49%)                  |
| Overall Incidence               Total 70/109 (64.22%) Mean 63.9%   SD 5.51%     Total 48/109 (44.04%)  Mean 43.58%  SD 7.89%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            12/50 (24%)   25/59 (42%)                        6/50 (12%)   25/59 (42%)                  |
| Overall Incidence               Total 37/109 (33.94%) Mean 33.19%  SD 12.99%    Total 31/109 (28.44%)  Mean 27.19%  SD 21.48%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         13/50 (26%)   27/59 (46%)                        6/50 (12%)   25/59 (42%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 40/109 (36.7%)  Mean 35.88%  SD 13.97%    Total 31/109 (28.44%)  Mean 27.19%  SD 21.48%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         35/50 (70%)   47/59 (80%)                       20/50 (40%)   41/59 (69%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 82/109 (75.23%) Mean 74.83%  SD 6.83%     Total 61/109 (55.96%)  Mean 54.75%  SD 20.85%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           35/50 (70%)   48/59 (81%)                       20/50 (40%)   41/59 (69%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 83/109 (76.15%) Mean 75.68%  SD 8.03%     Total 61/109 (55.96%)  Mean 54.75%  SD 20.85%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 708
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              1/50 (2%)     0/59 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 1%      SD 1.41%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        15/50 (30%)   12/60 (20%)                        4/50 (8%)     2/59 (3%)                   |
| Overall Incidence               Total 27/110 (24.55%) Mean 25%     SD 7.07%     Total 6/109 (5.5%)     Mean 5.69%   SD 3.26%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    4/60 (7%)                         1/50 (2%)     3/59 (5%)                   |
| Overall Incidence               Total 12/110 (10.91%) Mean 11.33%  SD 6.6%      Total 4/109 (3.67%)    Mean 3.54%   SD 2.18%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   21/50 (42%)   15/60 (25%)                        5/50 (10%)    4/59 (7%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 36/110 (32.73%) Mean 33.5%   SD 12.02%    Total 9/109 (8.26%)    Mean 8.39%   SD 2.28%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 709
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 710
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 711
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 712
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              2/46 (4%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 2/104 (1.92%)    Mean 2.17%   SD 3.07%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/46 (0%)     2/58 (3%)                   |
| Overall Incidence                                                               Total 2/104 (1.92%)    Mean 1.72%   SD 2.44%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/46 (0%)     0/58 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 713
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/46 (2%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/104 (0.96%)    Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/46 (0%)     1/58 (2%)                   |
| Overall Incidence                                                               Total 1/104 (0.96%)    Mean 0.86%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/46 (2%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/104 (0.96%)    Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/46 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 714
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/58 (0%)                         1/50 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/58 (0%)                         1/50 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 1/109 (0.92%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/58 (0%)                         0/50 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/108 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)     0/55 (0%)                         0/47 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/104 (0%)      Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/52 (0%)                         5/48 (10%)   11/56 (20%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 16/104 (15.38%)  Mean 15.03%  SD 6.52%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/52 (0%)                         0/48 (0%)     0/56 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/52 (0%)                         5/48 (10%)   11/56 (20%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 16/104 (15.38%)  Mean 15.03%  SD 6.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 715
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/52 (0%)                         1/48 (2%)     0/56 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/104 (0.96%)    Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/52 (0%)                         0/48 (0%)     0/56 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/104 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/52 (0%)                         1/48 (2%)     0/56 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/104 (0.96%)    Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/49 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/109 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 716
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 717
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 718
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 719
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/60 (2%)                         2/50 (4%)     0/60 (0%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 2/110 (1.82%)    Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/60 (2%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/60 (2%)                         2/50 (4%)     0/60 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 2/110 (1.82%)    Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 720
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/59 (0%)                         1/49 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 1/108 (0.93%)    Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/50 (2%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/109 (0.92%)   Mean 1%      SD 1.41%     Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      3/50 (6%)     1/59 (2%)                         1/49 (2%)     1/59 (2%)                   |
| Overall Incidence               Total 4/109 (3.67%)   Mean 3.85%   SD 3.04%     Total 2/108 (1.85%)    Mean 1.87%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)                         1/50 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/60 (2%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 0.83%   SD 1.18%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 721
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/60 (2%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/110 (0.91%)   Mean 1%      SD 1.41%     Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     1/60 (2%)                                                                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/53 (0%)                         1/48 (2%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/105 (0.95%)    Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           1/47 (2%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1.06%   SD 1.5%      Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     1/53 (2%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 0.94%   SD 1.33%     Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 722
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/53 (0%)                         1/48 (2%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/105 (0.95%)    Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/53 (0%)                         0/48 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/105 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/53 (0%)                         1/48 (2%)     0/57 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/105 (0.95%)    Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/60 (2%)                         2/50 (4%)     2/58 (3%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 4/108 (3.7%)     Mean 3.72%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/60 (2%)                         2/50 (4%)     2/58 (3%)                   |
| Overall Incidence               Total 2/110 (1.82%)   Mean 1.83%   SD 0.24%     Total 4/108 (3.7%)     Mean 3.72%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 723
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 724
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/59 (0%)                         0/49 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/109 (0%)      Mean 0%      SD 0%        Total 0/108 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     1/60 (2%)                   |
| Overall Incidence                                                               Total 1/110 (0.91%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       1/50 (2%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     1/60 (2%)                   |
| Overall Incidence                                                               Total 1/110 (0.91%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 725
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 1/110 (0.91%)    Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     1/60 (2%)                   |
| Overall Incidence                                                               Total 1/110 (0.91%)    Mean 0.83%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)                         0/50 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/110 (0%)      Mean 0%      SD 0%        Total 0/110 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 727
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       22/50 (44%)                                     34/50 (68%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    32/50 (64%)                                     35/50 (70%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)                                     48/50 (96%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)                                      11/50 (22%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 728
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)                                       1/50 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 729
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 730
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 731
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 732
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 733
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 734
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 735
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              14/50 (28%)                                     24/49 (49%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            18/50 (36%)                                     16/49 (33%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         20/50 (40%)                                     16/49 (33%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)                                     33/49 (67%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           30/50 (60%)                                     33/49 (67%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 736
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         9/50 (18%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   13/50 (26%)                                      2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 737
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 738
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 739
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 740
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          4/46 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/46 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/46 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 741
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/46 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 742
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                      11/46 (24%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       0/46 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                      11/46 (24%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 743
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 744
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 745
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       1/50 (2%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       1/50 (2%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       2/50 (4%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 746
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       1/50 (2%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 747
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       2/50 (4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       2/50 (4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 748
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)                                       1/47 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 749
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 750
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 751
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 752
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 753
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 755
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       29/50 (58%)                                     26/50 (52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)                                     25/50 (50%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         40/50 (80%)                                     40/50 (80%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     6/50 (12%)                                     15/50 (30%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 756
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       0/50 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 757
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 758
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 759
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 760
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 761
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 762
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 763
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)                                     17/50 (34%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          8/50 (16%)                                      6/50 (12%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/50 (54%)                                     21/50 (42%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/50 (54%)                                     21/50 (42%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 764
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   11/50 (22%)                                      6/50 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 765
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 766
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 767
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 768
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 769
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 770
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/46 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       3/49 (6%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/49 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       3/49 (6%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 771
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/48 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/48 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 772
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 773
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 774
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 775
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)                                       0/50 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 776
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 777
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/43 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 778
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 779
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 780
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 781
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 783
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       41/50 (82%)   35/50 (70%)                       42/50 (84%)   40/50 (80%)                  |
| Overall Incidence               Total 76/100 (76%)    Mean 76%     SD 8.49%     Total 82/100 (82%)     Mean 82%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    32/50 (64%)   22/50 (44%)                       28/50 (56%)   26/50 (52%)                  |
| Overall Incidence               Total 54/100 (54%)    Mean 54%     SD 14.14%    Total 54/100 (54%)     Mean 54%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         48/50 (96%)   43/50 (86%)                       46/50 (92%)   47/50 (94%)                  |
| Overall Incidence               Total 91/100 (91%)    Mean 91%     SD 7.07%     Total 93/100 (93%)     Mean 93%     SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      5/50 (10%)    2/50 (4%)                         4/50 (8%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 4.24%     Total 4/100 (4%)       Mean 4%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        7/50 (14%)    2/50 (4%)                         5/50 (10%)    0/50 (0%)                   |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 7.07%     Total 5/100 (5%)       Mean 5%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  2/50 (4%)     1/50 (2%)                         2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 4/100 (4%)       Mean 4%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     3/50 (6%)                        10/50 (20%)    6/50 (12%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 16/100 (16%)     Mean 16%     SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 784
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     3/49 (6%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.06%   SD 4.33%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/48 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/48 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/48 (0%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/48 (0%)                         1/50 (2%)     0/49 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 785
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 786
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 787
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/43 (0%)                         0/42 (0%)     0/37 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/79 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/50 (2%)     3/50 (6%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 3/100 (3%)       Mean 3%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     2/50 (4%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)     5/50 (10%)                        5/50 (10%)    1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 6/100 (6%)       Mean 6%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 788
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 789
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     0/49 (0%)                         1/50 (2%)     1/49 (2%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 790
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     0/49 (0%)                         1/50 (2%)     1/49 (2%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 791
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)     1/50 (2%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       6/50 (12%)    2/50 (4%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 5.66%     Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              35/50 (70%)   29/50 (58%)                       40/50 (80%)   37/49 (76%)                  |
| Overall Incidence               Total 64/100 (64%)    Mean 64%     SD 8.49%     Total 77/99 (77.78%)   Mean 77.76%  SD 3.17%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            13/50 (26%)   15/50 (30%)                        6/50 (12%)   13/49 (27%)                  |
| Overall Incidence               Total 28/100 (28%)    Mean 28%     SD 2.83%     Total 19/99 (19.19%)   Mean 19.27%  SD 10.27%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         18/50 (36%)   17/50 (34%)                        6/50 (12%)   13/49 (27%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 35/100 (35%)    Mean 35%     SD 1.41%     Total 19/99 (19.19%)   Mean 19.27%  SD 10.27%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         39/50 (78%)   37/50 (74%)                       41/50 (82%)   41/49 (84%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 76/100 (76%)    Mean 76%     SD 2.83%     Total 82/99 (82.83%)   Mean 82.84%  SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           40/50 (80%)   38/50 (76%)                       41/50 (82%)   41/49 (84%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 78/100 (78%)    Mean 78%     SD 2.83%     Total 82/99 (82.83%)   Mean 82.84%  SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 792
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)   12/49 (24%)                        4/50 (8%)     2/50 (4%)                   |
| Overall Incidence               Total 24/99 (24.24%)  Mean 24.24%  SD 0.35%     Total 6/100 (6%)       Mean 6%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     1/49 (2%)                         5/50 (10%)    2/50 (4%)                   |
| Overall Incidence               Total 5/99 (5.05%)    Mean 5.02%   SD 4.21%     Total 7/100 (7%)       Mean 7%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)   13/49 (27%)                        9/50 (18%)    4/50 (8%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 29/99 (29.29%)  Mean 29.27%  SD 3.87%     Total 13/100 (13%)     Mean 13%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 793
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 794
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 795
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 796
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/50 (2%)     4/47 (9%)                   |
| Overall Incidence                                                               Total 5/97 (5.15%)     Mean 5.26%   SD 4.6%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     1/47 (2%)                   |
| Overall Incidence                                                               Total 2/97 (2.06%)     Mean 2.06%   SD 0.09%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     1/47 (2%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 2/97 (2.06%)     Mean 2.06%   SD 0.09%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 797
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/50 (2%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 1/97 (1.03%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 798
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/48 (0%)     0/31 (0%)                         0/49 (0%)     0/31 (0%)                   |
| Overall Incidence               Total 0/79 (0%)       Mean 0%      SD 0%        Total 0/80 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/46 (0%)                         6/49 (12%)    8/47 (17%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 14/96 (14.58%)   Mean 14.63%  SD 3.38%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/46 (0%)                         0/49 (0%)     0/47 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/46 (0%)                         6/49 (12%)    8/47 (17%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 14/96 (14.58%)   Mean 14.63%  SD 3.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 799
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/46 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/46 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/46 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 800
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 801
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 802
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 803
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 804
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     1/49 (2%)                         1/49 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1.02%   SD 1.44%     Total 1/98 (1.02%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 805
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 806
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/37 (0%)     0/46 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/99 (1.01%)    Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     2/49 (4%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.04%   SD 1.47%     Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     2/49 (4%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 3/99 (3.03%)    Mean 3.04%   SD 1.47%     Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 807
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     1/48 (2%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%     Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 808
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           1/50 (2%)     0/48 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1%      SD 1.41%     Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     1/48 (2%)                         0/48 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%     Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 809
 Version: 01/12/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: TSI MASON RESEARCH                        Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 23-DEC-1999
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 4/100 (4%)       Mean 4%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
