                                                 Toxicology Data Management System                                     Page: 1
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON                                    |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON                                    |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   735       50( )      37  (695)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   40/100(40%)   27/50 (54%)         29/50 (58%)   28/99 (28%)   22/50 (44%)    |
|                                       29/50 (58%)   29/49 (59%)   16/50 (32%)         17/50 (34%)   24/50 (48%)   15/50 (30%)    |
|                                       28/50 (56%)   37/100(37%)                       13/50 (26%)   32/100(32%)                  |
| Overall Incidence               Total 240/499 (48.1%) Mean 50.52%  SD 12.62%    Total 180/499 (36.07%) Mean 37.54%  SD 11.27%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   32/100(32%)   19/50 (38%)         24/50 (48%)   24/99 (24%)   18/50 (36%)    |
|                                       24/50 (48%)   24/49 (49%)   21/50 (42%)         17/50 (34%)   20/50 (40%)   12/50 (24%)    |
|                                       27/50 (54%)   28/100(28%)                       12/50 (24%)   46/100(46%)                  |
| Overall Incidence               Total 204/499 (40.88%)Mean 43.62%  SD 10.53%    Total 173/499 (34.67%) Mean 34.53%  SD 9.8%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   55/100(55%)   39/50 (78%)         39/50 (78%)   45/99 (45%)   32/50 (64%)    |
|                                       38/50 (76%)   40/49 (82%)   32/50 (64%)         29/50 (58%)   34/50 (68%)   23/50 (46%)    |
|                                       40/50 (80%)   57/100(57%)                       21/50 (42%)   62/100(62%)                  |
| Overall Incidence               Total 346/499 (69.34%)Mean 72.7%   SD 12.57%    Total 285/499 (57.11%) Mean 57.93%  SD 12.59%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     2/100(2%)     2/50 (4%)           0/50 (0%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     3/100(3%)                         0/50 (0%)     4/100(4%)                   |
| Overall Incidence               Total 9/499 (1.8%)    Mean 1.63%   SD 1.85%     Total 9/499 (1.8%)     Mean 1.63%   SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/100(3%)     0/50 (0%)           4/50 (8%)     0/99 (0%)     3/50 (6%)     |
|                                        6/50 (12%)    3/49 (6%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        7/50 (14%)    2/100(2%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 27/499 (5.41%)  Mean 6.14%   SD 4.79%     Total 12/499 (2.4%)    Mean 2.88%   SD 2.9%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    5/100(5%)     2/50 (4%)           4/50 (8%)     1/99 (1%)     5/50 (10%)    |
|                                        6/50 (12%)    3/49 (6%)     3/50 (6%)           1/50 (2%)     4/50 (8%)     0/50 (0%)     |
|                                        7/50 (14%)    5/100(5%)                         1/50 (2%)     5/100(5%)                   |
| Overall Incidence               Total 36/499 (7.21%)  Mean 7.77%   SD 3.72%     Total 21/499 (4.21%)   Mean 4.5%    SD 3.78%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 3/499 (0.6%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     4/100(4%)     1/50 (2%)           4/50 (8%)     7/99 (7%)     5/50 (10%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     2/49 (4%)     3/50 (6%)           7/50 (14%)    9/50 (18%)    6/50 (12%)    |
|      Undifferentiated Cell Type        1/50 (2%)     8/100(8%)                         7/50 (14%)   23/100(23%)                  |
| Overall Incidence               Total 25/499 (5.01%)  Mean 4.76%   SD 2.12%     Total 68/499 (13.63%)  Mean 13.26%  SD 5.3%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/49 (10%)    0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/99 (2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 14/497 (2.82%)  Mean 3.03%   SD 3.6%      Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/496 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/50 (0%)     1/99 (1%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 3/496 (0.6%)     Mean 0.5%    SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/50 (0%)     1/99 (1%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 3/496 (0.6%)     Mean 0.5%    SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/499 (1.2%)    Mean 1.5%    SD 2.07%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.38%   SD 0.74%     Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/499 (0.2%)     Mean 0.13%   SD 0.36%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/497 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/497 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/497 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/497 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.25%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.25%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/100(1%)                                                                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/48 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/40 (0%)     0/46 (0%)     0/49 (0%)           0/39 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/48 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/483 (0%)      Mean 0%      SD 0%        Total 0/485 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    4/100(4%)     2/50 (4%)          10/50 (20%)    3/99 (3%)     1/50 (2%)     |
|                                        6/50 (12%)    3/49 (6%)     5/50 (10%)          4/50 (8%)     2/50 (4%)     3/50 (6%)     |
|                                        4/50 (8%)     8/100(8%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 37/499 (7.41%)  Mean 7.77%   SD 2.91%     Total 25/499 (5.01%)   Mean 5.63%   SD 6.32%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     1/50 (2%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.5%    SD 0.93%     Total 5/499 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    4/100(4%)     3/50 (6%)          11/50 (22%)    4/99 (4%)     1/50 (2%)     |
|                                        6/50 (12%)    3/49 (6%)     5/50 (10%)          4/50 (8%)     4/50 (8%)     3/50 (6%)     |
|                                        4/50 (8%)     8/100(8%)                         0/50 (0%)     3/100(3%)                   |
| Overall Incidence               Total 39/499 (7.82%)  Mean 8.27%   SD 2.9%      Total 30/499 (6.01%)   Mean 6.63%   SD 6.82%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 1/498 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.51%   SD 1.44%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     2/100(2%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 7/499 (1.4%)    Mean 1.38%   SD 1.41%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 17/499 (3.41%)  Mean 3.76%   SD 3.49%     Total 2/499 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.51%   SD 1.44%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 17/499 (3.41%)  Mean 3.76%   SD 3.49%     Total 2/499 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     3/49 (6%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 19/499 (3.81%)  Mean 4.27%   SD 3.5%      Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     2/100(2%)     2/50 (4%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 8/499 (1.6%)    Mean 1.63%   SD 1.69%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 8/499 (1.6%)    Mean 1.89%   SD 2.43%     Total 2/495 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/495 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 8/499 (1.6%)    Mean 1.89%   SD 2.43%     Total 3/495 (0.61%)    Mean 0.75%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/497 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     2/100(2%)     0/50 (0%)           2/50 (4%)     0/99 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     1/49 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 11/499 (2.2%)   Mean 2.51%   SD 1.77%     Total 5/498 (1%)       Mean 1.25%   SD 1.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 7/499 (1.4%)    Mean 1.76%   SD 3.45%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   20/100(20%)   17/50 (34%)         14/50 (28%)    8/99 (8%)    11/50 (22%)    |
|                                       19/50 (38%)   17/49 (35%)    6/50 (12%)          7/50 (14%)    9/50 (18%)    4/50 (8%)     |
|                                       19/50 (38%)   14/100(14%)                        9/50 (18%)    7/99 (7%)                   |
| Overall Incidence               Total 135/499 (27.05%)Mean 29.59%  SD 12.54%    Total 69/498 (13.86%)  Mean 15.39%  SD 7.52%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)   13/100(13%)   14/50 (28%)          7/50 (14%)    4/99 (4%)     7/50 (14%)    |
|                                       11/50 (22%)   13/49 (27%)    9/50 (18%)          3/50 (6%)     2/50 (4%)     3/50 (6%)     |
|                                        9/50 (18%)   13/100(13%)                        2/50 (4%)     3/99 (3%)                   |
| Overall Incidence               Total 96/499 (19.24%) Mean 20.82%  SD 6.27%     Total 31/498 (6.22%)   Mean 6.88%   SD 4.51%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   13/100(13%)   14/50 (28%)          7/50 (14%)    4/99 (4%)     7/50 (14%)    |
|      Hepatoblastoma                   12/50 (24%)   14/49 (29%)    9/50 (18%)          3/50 (6%)     2/50 (4%)     3/50 (6%)     |
|                                       12/50 (24%)   13/100(13%)                        2/50 (4%)     3/99 (3%)                   |
| Overall Incidence               Total 101/499 (20.24%)Mean 22.07%  SD 6.56%     Total 31/498 (6.22%)   Mean 6.88%   SD 4.51%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   28/100(28%)   29/50 (58%)         20/50 (40%)   12/99 (12%)   17/50 (34%)    |
|      Hepatocellular Adenoma           23/50 (46%)   24/49 (49%)   15/50 (30%)         10/50 (20%)   10/50 (20%)    6/50 (12%)    |
|                                       24/50 (48%)   26/100(26%)                       10/50 (20%)    9/99 (9%)                   |
| Overall Incidence               Total 201/499 (40.28%)Mean 43.62%  SD 14.22%    Total 94/498 (18.88%)  Mean 20.9%   SD 10.92%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   28/100(28%)   29/50 (58%)         20/50 (40%)   12/99 (12%)   17/50 (34%)    |
|      Hepatocellular Adenoma, or       24/50 (48%)   24/49 (49%)   15/50 (30%)         10/50 (20%)   10/50 (20%)    6/50 (12%)    |
|      Hepatoblastoma                   26/50 (52%)   26/100(26%)                       10/50 (20%)    9/99 (9%)                   |
| Overall Incidence               Total 204/499 (40.88%)Mean 44.37%  SD 14.52%    Total 94/498 (18.88%)  Mean 20.9%   SD 10.92%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/99 (0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.26%   SD 0.72%     Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   12/100(12%)    3/50 (6%)           4/50 (8%)     5/99 (5%)     2/50 (4%)     |
|                                       10/50 (20%)    2/49 (4%)     6/50 (12%)          2/50 (4%)     6/50 (12%)    0/50 (0%)     |
|                                       10/50 (20%)    9/100(9%)                         1/50 (2%)     3/100(3%)                   |
| Overall Incidence               Total 62/499 (12.42%) Mean 12.89%  SD 6.47%     Total 23/499 (4.61%)   Mean 4.76%   SD 3.73%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     9/100(9%)     3/50 (6%)           2/50 (4%)     6/99 (6%)     2/50 (4%)     |
|                                        5/50 (10%)    4/49 (8%)     7/50 (14%)          1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        4/50 (8%)     7/100(7%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 43/499 (8.62%)  Mean 8.77%   SD 2.43%     Total 14/499 (2.81%)   Mean 2.51%   SD 2.08%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   20/100(20%)    6/50 (12%)          6/50 (12%)   11/99 (11%)    3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma     14/50 (28%)    6/49 (12%)   13/50 (26%)          3/50 (6%)     6/50 (12%)    0/50 (0%)     |
|                                       13/50 (26%)   14/100(14%)                        1/50 (2%)     5/100(5%)                   |
| Overall Incidence               Total 100/499 (20.04%)Mean 20.78%  SD 7.12%     Total 35/499 (7.01%)   Mean 6.76%   SD 4.57%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.5%    SD 1.41%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|      or Adenoma                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.38%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 3/499 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    3/99 (3%)     0/50 (0%)     |
|                                                                                        1/47 (2%)     2/50 (4%)     2/50 (4%)     |
|                                                                                        0/47 (0%)     2/100(2%)                   |
| Overall Incidence                                                               Total 18/493 (3.65%)   Mean 3.89%   SD 5.13%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 4/493 (0.81%)    Mean 0.75%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Malignant, NOS                                                                    0/47 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 4/493 (0.81%)    Mean 0.75%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 3/493 (0.61%)    Mean 0.63%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 1/493 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     2/100(2%)                   |
| Overall Incidence                                                               Total 3/493 (0.61%)    Mean 0.38%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/493 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 1/493 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/498 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/495 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 0/495 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           2/48 (4%)     8/97 (8%)     1/49 (2%)     |
|   Adenoma                              0/47 (0%)     0/48 (0%)     0/49 (0%)           2/48 (4%)     2/49 (4%)     3/48 (6%)     |
|                                        0/49 (0%)     0/98 (0%)                         1/48 (2%)    11/97 (11%)                  |
| Overall Incidence               Total 0/487 (0%)      Mean 0%      SD 0%        Total 30/484 (6.2%)    Mean 5.3%    SD 3.19%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           0/48 (0%)     0/97 (0%)     0/49 (0%)     |
|   Carcinoma                            0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/98 (0%)                         0/48 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 0/487 (0%)      Mean 0%      SD 0%        Total 0/484 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           2/48 (4%)     8/97 (8%)     1/49 (2%)     |
|   Carcinoma or Adenoma                 0/47 (0%)     0/48 (0%)     0/49 (0%)           2/48 (4%)     2/49 (4%)     3/48 (6%)     |
|                                        0/49 (0%)     0/98 (0%)                         1/48 (2%)    11/97 (11%)                  |
| Overall Incidence               Total 0/487 (0%)      Mean 0%      SD 0%        Total 30/484 (6.2%)    Mean 5.3%    SD 3.19%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/98 (0%)     1/49 (2%)           0/48 (0%)     2/97 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     2/49 (4%)     1/48 (2%)     |
|                                        0/49 (0%)     1/98 (1%)                         0/48 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 3/487 (0.62%)   Mean 0.64%   SD 0.93%     Total 5/484 (1.03%)    Mean 1.03%   SD 1.55%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/98 (0%)     1/49 (2%)           0/48 (0%)     2/97 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     2/49 (4%)     1/48 (2%)     |
|                                        0/49 (0%)     1/98 (1%)                         0/48 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 3/487 (0.62%)   Mean 0.64%   SD 0.93%     Total 5/484 (1.03%)    Mean 1.03%   SD 1.55%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.26%   SD 0.72%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/490 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/490 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 3/499 (0.6%)     Mean 0.63%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     1/100(1%)                         0/50 (0%)     1/100(1%)                   |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.38%   SD 0.76%     Total 2/499 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 3/499 (0.6%)    Mean 0.38%   SD 0.74%     Total 2/499 (0.4%)     Mean 0.25%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.5%    SD 0.93%     Total 2/499 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.38%   SD 0.76%     Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.38%   SD 0.76%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/100(1%)     0/50 (0%)           3/50 (6%)     2/99 (2%)     3/50 (6%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/100(0%)                         1/50 (2%)     4/100(4%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 19/499 (3.81%)   Mean 4%      SD 1.85%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     4/100(4%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 8/499 (1.6%)     Mean 1.5%    SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/100(1%)     0/50 (0%)           3/50 (6%)     2/99 (2%)     3/50 (6%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/100(0%)                         1/50 (2%)     4/100(4%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%     Total 19/499 (3.81%)   Mean 4%      SD 1.85%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 4/499 (0.8%)     Mean 0.75%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 4/499 (0.8%)     Mean 0.75%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     3/50 (6%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 10/499 (2%)      Mean 2.25%   SD 2.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 4/499 (0.8%)     Mean 0.75%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 0/491 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     1/49 (2%)     1/50 (2%)           0/47 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        3/50 (6%)     1/100(1%)                         0/49 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 7/498 (1.41%)   Mean 1.63%   SD 2%        Total 2/491 (0.41%)    Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 1/498 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/491 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/97 (0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 0/491 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     0/100(0%)     1/50 (2%)           3/50 (6%)     1/99 (1%)     2/50 (4%)     |
|      Papilloma Squamous                0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 6/499 (1.2%)    Mean 1.51%   SD 2.07%     Total 8/499 (1.6%)     Mean 1.75%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     0/100(0%)     0/50 (0%)           3/50 (6%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 5/499 (1%)      Mean 1.26%   SD 2.12%     Total 8/499 (1.6%)     Mean 1.75%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/100(1%)     3/50 (6%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     1/100(1%)                                                                   |
| Overall Incidence               Total 6/499 (1.2%)    Mean 1.25%   SD 2.05%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.13%   SD 0.35%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/100(1%)                                                                   |
| Overall Incidence               Total 2/499 (0.4%)    Mean 0.38%   SD 0.74%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     1/49 (2%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)                         0/46 (0%)     0/93 (0%)                   |
| Overall Incidence               Total 0/441 (0%)      Mean 0%      SD 0%        Total 1/472 (0.21%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)                         1/46 (2%)     0/93 (0%)                   |
| Overall Incidence               Total 0/441 (0%)      Mean 0%      SD 0%        Total 1/472 (0.21%)    Mean 0.27%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)                         1/46 (2%)     0/93 (0%)                   |
| Overall Incidence               Total 0/441 (0%)      Mean 0%      SD 0%        Total 1/472 (0.21%)    Mean 0.27%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/488 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 1/496 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/488 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 1/496 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/488 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/50 (2%)           0/46 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/99 (1%)                         0/49 (0%)     1/98 (1%)                   |
| Overall Incidence               Total 3/496 (0.6%)    Mean 0.5%    SD 0.76%     Total 5/488 (1.02%)    Mean 1.13%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)                         0/49 (0%)     0/98 (0%)                   |
| Overall Incidence               Total 1/496 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/488 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     1/50 (2%)           0/46 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/99 (1%)                         0/49 (0%)     1/98 (1%)                   |
| Overall Incidence               Total 4/496 (0.81%)   Mean 0.76%   SD 0.9%      Total 5/488 (1.02%)    Mean 1.13%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.38%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 2/499 (0.4%)     Mean 0.38%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/499 (0.2%)    Mean 0.26%   SD 0.72%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/492 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/492 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/492 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/492 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 2/499 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 7/499 (1.4%)     Mean 1.38%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 7/499 (1.4%)     Mean 1.38%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/499 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)   29/50 (58%)   31/50 (62%)         28/50 (56%)   25/50 (50%)   19/50 (38%)    |
| Overall Incidence               Total 92/150 (61.33%) Mean 61.33%  SD 3.06%     Total 72/150 (48%)     Mean 48%     SD 9.17%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   21/50 (42%)   27/50 (54%)         22/50 (44%)   20/50 (40%)   17/50 (34%)    |
| Overall Incidence               Total 71/150 (47.33%) Mean 47.33%  SD 6.11%     Total 59/150 (39.33%)  Mean 39.33%  SD 5.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   41/50 (82%)   42/50 (84%)         39/50 (78%)   35/50 (70%)   32/50 (64%)    |
| Overall Incidence               Total 126/150 (84%)   Mean 84%     SD 2%        Total 106/150 (70.67%) Mean 70.67%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     3/50 (6%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 5/150 (3.33%)   Mean 3.33%   SD 2.31%     Total 6/150 (4%)       Mean 4%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     3/50 (6%)     1/50 (2%)           2/50 (4%)     4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 5/150 (3.33%)   Mean 3.33%   SD 2.31%     Total 8/150 (5.33%)    Mean 5.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)     2/50 (4%)          11/50 (22%)    8/50 (16%)    7/50 (14%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 6/150 (4%)      Mean 4%      SD 2%        Total 26/150 (17.33%)  Mean 17.33%  SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                                                                                                                         |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/149 (3.36%)   Mean 3.36%   SD 1.18%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     2/49 (4%)     2/49 (4%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 6/147 (4.08%)    Mean 4.08%   SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     2/49 (4%)     2/49 (4%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 6/147 (4.08%)    Mean 4.08%   SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/49 (2%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 2/148 (1.35%)   Mean 1.36%   SD 1.18%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/42 (0%)     0/43 (0%)     0/42 (0%)           0/42 (0%)     0/46 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/127 (0%)      Mean 0%      SD 0%        Total 0/134 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    1/50 (2%)     8/50 (16%)          3/50 (6%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 15/150 (10%)    Mean 10%     SD 7.21%     Total 8/150 (5.33%)    Mean 5.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            3/50 (6%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 3.46%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    1/50 (2%)     8/50 (16%)          4/50 (8%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 18/150 (12%)    Mean 12%     SD 8.72%     Total 9/150 (6%)       Mean 6%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     3/50 (6%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/149 (3.36%)   Mean 3.35%   SD 2.3%      Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     3/50 (6%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/149 (3.36%)   Mean 3.35%   SD 2.3%      Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/150 (2.67%)   Mean 2.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)   17/50 (34%)   15/50 (30%)          7/50 (14%)   12/50 (24%)    6/50 (12%)    |
| Overall Incidence               Total 54/150 (36%)    Mean 36%     SD 7.21%     Total 25/150 (16.67%)  Mean 16.67%  SD 6.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   11/50 (22%)   14/50 (28%)          4/50 (8%)     6/50 (12%)    6/50 (12%)    |
| Overall Incidence               Total 35/150 (23.33%) Mean 23.33%  SD 4.16%     Total 16/150 (10.67%)  Mean 10.67%  SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   11/50 (22%)   14/50 (28%)          4/50 (8%)     6/50 (12%)    6/50 (12%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 35/150 (23.33%) Mean 23.33%  SD 4.16%     Total 16/150 (10.67%)  Mean 10.67%  SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)   26/50 (52%)   26/50 (52%)         11/50 (22%)   18/50 (36%)   12/50 (24%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 80/150 (53.33%) Mean 53.33%  SD 2.31%     Total 41/150 (27.33%)  Mean 27.33%  SD 7.57%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)   26/50 (52%)   26/50 (52%)         11/50 (22%)   18/50 (36%)   12/50 (24%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 80/150 (53.33%) Mean 53.33%  SD 2.31%     Total 41/150 (27.33%)  Mean 27.33%  SD 7.57%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   13/50 (26%)   13/50 (26%)          1/50 (2%)     3/50 (6%)     1/50 (2%)     |
| Overall Incidence               Total 34/150 (22.67%) Mean 22.67%  SD 5.77%     Total 5/150 (3.33%)    Mean 3.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    6/50 (12%)   12/50 (24%)          6/50 (12%)    1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 26/150 (17.33%) Mean 17.33%  SD 6.11%     Total 7/150 (4.67%)    Mean 4.67%   SD 6.43%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   18/50 (36%)   22/50 (44%)          7/50 (14%)    4/50 (8%)     1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 55/150 (36.67%) Mean 36.67%  SD 7.02%     Total 12/150 (8%)      Mean 8%      SD 6%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/50 (2%)     0/47 (0%)     1/48 (2%)     |
| Overall Incidence                                                               Total 2/145 (1.38%)    Mean 1.36%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/145 (0.69%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/47 (0%)     0/48 (0%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/145 (0.69%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/50 (2%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/145 (0.69%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/50 (2%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/145 (0.69%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/47 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     1/50 (2%)          13/50 (26%)   10/50 (20%)    8/49 (16%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 2/146 (1.37%)   Mean 1.36%   SD 1.18%     Total 31/149 (20.81%)  Mean 20.78%  SD 4.88%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 1/146 (0.68%)   Mean 0.67%   SD 1.15%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     2/50 (4%)          13/50 (26%)   10/50 (20%)    8/49 (16%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 3/146 (2.05%)   Mean 2.03%   SD 2%        Total 31/149 (20.81%)  Mean 20.78%  SD 4.88%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/146 (0%)      Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/146 (0%)      Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.33%   SD 2.31%     Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 4/150 (2.67%)   Mean 2.67%   SD 2.31%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     2/50 (4%)     0/50 (0%)                                                     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/35 (0%)     0/35 (0%)           0/48 (0%)     0/47 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/114 (0%)      Mean 0%      SD 0%        Total 0/139 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/35 (0%)     0/35 (0%)           0/48 (0%)     0/47 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/114 (0%)      Mean 0%      SD 0%        Total 0/139 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/35 (0%)     0/35 (0%)           0/48 (0%)     0/47 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/114 (0%)      Mean 0%      SD 0%        Total 0/139 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/47 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)     0/47 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/143 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)     1/47 (2%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/143 (0.7%)    Mean 0.71%   SD 1.23%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)     1/47 (2%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/143 (0.7%)    Mean 0.71%   SD 1.23%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 49
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       54/100(54%)                                     52/100(52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    40/100(40%)                                     55/100(55%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/100(71%)                                     78/100(78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/100(1%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/100(8%)                                      32/100(32%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/100(0%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/99 (3%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/99 (0%)                                       1/92 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/98 (1%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            2/98 (2%)                                       0/90 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               1/99 (1%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)                                       0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                             12/100(12%)                                     10/100(10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                12/100(12%)                                     12/100(12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/99 (1%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/99 (2%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/99 (2%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/100(4%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/100(2%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/100(30%)                                     17/98 (17%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            19/100(19%)                                      6/98 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/100(21%)                                      6/98 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         46/100(46%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           47/100(47%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/100(0%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        26/100(26%)                                      9/95 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/100(8%)                                       2/95 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   30/100(30%)                                     11/95 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/100(0%)                                       1/100(1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/79 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/79 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/79 (3%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                       0/83 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/100(0%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       1/100(1%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/100(0%)                                       1/100(1%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/100(0%)                                       1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       1/100(1%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/100(0%)                                       4/100(4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/100(0%)                                       4/100(4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       2/100(2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       2/100(2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/99 (2%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       1/91 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)                                       1/100(1%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/99 (1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              1/99 (1%)                                       2/92 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 67
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       37/50 (74%)   30/60 (50%)   25/50 (50%)         27/50 (54%)   21/60 (35%)   17/50 (34%)    |
|                                       32/50 (64%)                                     15/50 (30%)                                |
| Overall Incidence               Total 124/210 (59.05%)Mean 59.5%   SD 11.7%     Total 80/210 (38.1%)   Mean 38.25%  SD 10.72%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   26/60 (43%)   14/50 (28%)         17/50 (34%)   16/60 (27%)    9/50 (18%)    |
|                                       29/50 (58%)                                     21/50 (42%)                                |
| Overall Incidence               Total 92/210 (43.81%) Mean 43.83%  SD 12.33%    Total 63/210 (30%)     Mean 30.17%  SD 10.25%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   45/60 (75%)   31/50 (62%)         39/50 (78%)   33/60 (55%)   21/50 (42%)    |
|                                       44/50 (88%)                                     31/50 (62%)                                |
| Overall Incidence               Total 165/210 (78.57%)Mean 78.75%  SD 13%       Total 124/210 (59.05%) Mean 59.25%  SD 15%       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     3/60 (5%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 0.92%   SD 1.07%     Total 4/210 (1.9%)     Mean 1.75%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     4/60 (7%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/210 (5.71%)  Mean 5.67%   SD 2.58%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    5/60 (8%)     1/50 (2%)           1/50 (2%)     3/60 (5%)     2/50 (4%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 14/210 (6.67%)  Mean 6.58%   SD 3.47%     Total 6/210 (2.86%)    Mean 2.75%   SD 2.22%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/60 (2%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 0.92%   SD 1.07%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     3/60 (5%)     3/50 (6%)           4/50 (8%)     8/60 (13%)    3/50 (6%)     |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)                                       7/50 (14%)                                |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 11/210 (5.24%)  Mean 5.25%   SD 0.96%     Total 22/210 (10.48%)  Mean 10.33%  SD 3.94%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              4/50 (8%)     2/60 (3%)     3/49 (6%)           0/50 (0%)     1/59 (2%)     0/50 (0%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/208 (5.77%)  Mean 5.89%   SD 1.92%     Total 1/209 (0.48%)    Mean 0.42%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/49 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/60 (0%)     0/49 (0%)           1/50 (2%)     0/59 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/207 (0%)      Mean 0%      SD 0%        Total 1/208 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/60 (0%)     0/49 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/207 (0.48%)   Mean 0.51%   SD 1.02%     Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/60 (0%)     0/49 (0%)           1/50 (2%)     0/59 (0%)     0/50 (0%)     |
|      Complex, Malignant, NOS           1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/207 (0.48%)   Mean 0.51%   SD 1.02%     Total 1/208 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)     0/54 (0%)     0/49 (0%)           0/44 (0%)     0/54 (0%)     0/49 (0%)     |
|                                        0/44 (0%)                                       1/45 (2%)                                 |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 1/192 (0.52%)    Mean 0.56%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/50 (14%)    4/60 (7%)     3/50 (6%)           7/50 (14%)    4/60 (7%)     2/50 (4%)     |
|                                        4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 18/210 (8.57%)  Mean 8.67%   SD 3.65%     Total 15/210 (7.14%)   Mean 7.17%   SD 4.73%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 5/210 (2.38%)   Mean 2.42%   SD 1.95%     Total 3/210 (1.43%)    Mean 1.42%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    5/60 (8%)     3/50 (6%)           7/50 (14%)    5/60 (8%)     2/50 (4%)     |
|                                        6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence               Total 23/210 (10.95%) Mean 11.08%  SD 5.23%     Total 18/210 (8.57%)   Mean 8.58%   SD 4.11%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/59 (0%)     0/50 (0%)           1/47 (2%)     0/60 (0%)     0/49 (0%)     |
|                                        3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 5/208 (2.4%)    Mean 2.53%   SD 3.05%     Total 1/205 (0.49%)    Mean 0.53%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/59 (0%)     0/50 (0%)           0/47 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/59 (0%)     0/50 (0%)           1/47 (2%)     0/60 (0%)     0/49 (0%)     |
|                                        3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 5/208 (2.4%)    Mean 2.53%   SD 3.05%     Total 1/205 (0.49%)    Mean 0.53%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/207 (0.97%)   Mean 1.01%   SD 1.17%     Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/207 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/207 (0.97%)   Mean 1.01%   SD 1.17%     Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/207 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 5/210 (2.38%)   Mean 2.42%   SD 1.07%     Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        3/50 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 6/210 (2.86%)   Mean 2.92%   SD 2.63%     Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   18/60 (30%)   14/50 (28%)         11/50 (22%)    7/60 (12%)    6/49 (12%)    |
|                                       16/50 (32%)                                      9/49 (18%)                                |
| Overall Incidence               Total 71/210 (33.81%) Mean 34%     SD 8.16%     Total 33/208 (15.87%)  Mean 16.07%  SD 4.98%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)   12/60 (20%)    8/50 (16%)          3/50 (6%)     2/60 (3%)     3/49 (6%)     |
|                                       23/50 (46%)                                      8/49 (16%)                                |
| Overall Incidence               Total 51/210 (24.29%) Mean 24.5%   SD 14.46%    Total 16/208 (7.69%)   Mean 7.95%   SD 5.73%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/60 (22%)    8/50 (16%)          3/50 (6%)     2/60 (3%)     3/49 (6%)     |
|      Hepatoblastoma                   24/50 (48%)                                      8/49 (16%)                                |
| Overall Incidence               Total 55/210 (26.19%) Mean 26.42%  SD 14.58%    Total 16/208 (7.69%)   Mean 7.95%   SD 5.73%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)   27/60 (45%)   20/50 (40%)         13/50 (26%)    9/60 (15%)    8/49 (16%)    |
|      Hepatocellular Adenoma           36/50 (72%)                                     16/49 (33%)                                |
| Overall Incidence               Total 114/210 (54.29%)Mean 54.75%  SD 14.86%    Total 46/208 (22.12%)  Mean 22.49%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)   28/60 (47%)   20/50 (40%)         13/50 (26%)    9/60 (15%)    8/49 (16%)    |
|      Hepatocellular Adenoma, or       36/50 (72%)                                     16/49 (33%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 115/210 (54.76%)Mean 55.17%  SD 14.52%    Total 46/208 (22.12%)  Mean 22.49%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 2%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/208 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/50 (22%)    9/60 (15%)    6/50 (12%)          2/49 (4%)     2/60 (3%)     5/50 (10%)    |
|                                       12/50 (24%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 38/210 (18.1%)  Mean 18.25%  SD 5.68%     Total 10/209 (4.78%)   Mean 4.85%   SD 3.54%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       9/50 (18%)    5/60 (8%)     2/50 (4%)           0/49 (0%)     3/60 (5%)     1/50 (2%)     |
|                                        7/50 (14%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 23/210 (10.95%) Mean 11.08%  SD 6.17%     Total 5/209 (2.39%)    Mean 2.25%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   19/50 (38%)   14/60 (23%)    8/50 (16%)          2/49 (4%)     5/60 (8%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma     18/50 (36%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 59/210 (28.1%)  Mean 28.33%  SD 10.48%    Total 15/209 (7.18%)   Mean 7.1%    SD 3.84%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/209 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 2/210 (0.95%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     1/59 (2%)     3/48 (6%)     |
|                                                                                        1/49 (2%)                                 |
| Overall Incidence                                                               Total 6/205 (2.93%)    Mean 3.01%   SD 2.17%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     0/59 (0%)     1/48 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/205 (0.49%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     0/59 (0%)     1/48 (2%)     |
|      Malignant, NOS                                                                    0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/205 (0.49%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/59 (0%)     1/48 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/205 (0.49%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     2/59 (3%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 3/205 (1.46%)    Mean 1.36%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/59 (0%)     0/50 (0%)           0/47 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/59 (0%)     0/50 (0%)           0/47 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 1/205 (0.49%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     1/53 (2%)     0/46 (0%)           2/46 (4%)     3/58 (5%)     0/45 (0%)     |
|   Adenoma                              1/49 (2%)                                       5/48 (10%)                                |
| Overall Incidence               Total 2/196 (1.02%)   Mean 0.98%   SD 1.14%     Total 10/197 (5.08%)   Mean 4.98%   SD 4.27%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/53 (0%)     0/46 (0%)           0/46 (0%)     0/58 (0%)     0/45 (0%)     |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/196 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     1/53 (2%)     0/46 (0%)           2/46 (4%)     3/58 (5%)     0/45 (0%)     |
|   Carcinoma or Adenoma                 1/49 (2%)                                       5/48 (10%)                                |
| Overall Incidence               Total 2/196 (1.02%)   Mean 0.98%   SD 1.14%     Total 10/197 (5.08%)   Mean 4.98%   SD 4.27%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/53 (0%)     0/46 (0%)           2/46 (4%)     0/58 (0%)     0/45 (0%)     |
|                                        0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/196 (0%)      Mean 0%      SD 0%        Total 2/197 (1.02%)    Mean 1.09%   SD 2.17%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/53 (0%)     0/46 (0%)           2/46 (4%)     0/58 (0%)     0/45 (0%)     |
|                                        0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/196 (0%)      Mean 0%      SD 0%        Total 2/197 (1.02%)    Mean 1.09%   SD 2.17%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           5/50 (10%)    0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 6/210 (2.86%)    Mean 3%      SD 4.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)                                       0/50 (0%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)                                       0/50 (0%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/50 (4%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)                                       0/50 (0%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.5%    SD 1.91%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.5%    SD 1.91%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.5%    SD 1.91%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)                                       3/50 (6%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 6/210 (2.86%)    Mean 2.92%   SD 2.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)                                       3/50 (6%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 6/210 (2.86%)    Mean 2.92%   SD 2.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)                                       0/50 (0%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     1/50 (2%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 5/210 (2.38%)    Mean 2.42%   SD 2.54%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     1/60 (2%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/208 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)     2/60 (3%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 5/208 (2.4%)    Mean 2.36%   SD 1.79%     Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/60 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/60 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)     0/60 (0%)     1/50 (2%)           2/50 (4%)     1/60 (2%)     0/50 (0%)     |
|      Papilloma Squamous                1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/210 (1.9%)    Mean 2%      SD 1.63%     Total 3/210 (1.43%)    Mean 1.42%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)     0/60 (0%)     1/50 (2%)           2/50 (4%)     1/60 (2%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/210 (1.9%)    Mean 2%      SD 1.63%     Total 3/210 (1.43%)    Mean 1.42%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/57 (0%)     0/47 (0%)           0/44 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/190 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/57 (0%)     0/47 (0%)           0/44 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/190 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/57 (0%)     0/47 (0%)           0/44 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/190 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/59 (2%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/208 (0.96%)   Mean 0.92%   SD 1.07%     Total 1/208 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/59 (2%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/208 (0.96%)   Mean 0.92%   SD 1.07%     Total 1/208 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     2/60 (3%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 0.83%   SD 1.67%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/206 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/206 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/206 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 1/206 (0.49%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 01/30/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 30-JAN-2002
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     2/60 (3%)     3/50 (6%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 5/210 (2.38%)    Mean 2.33%   SD 2.91%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     2/60 (3%)     3/50 (6%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 5/210 (2.38%)    Mean 2.33%   SD 2.91%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
