                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   726      100(3)      52  (681)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(3)      23  (662)    519.6     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   727       50(3)      26  (667)    483.6     ELMIRON                                    |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   731      100(3)      60  (689)    492.1     TRANS-CINNAMALDEHYDE                       |
|BATTELLE NORTHWEST 059302607  08/14/97   733       50( )      28  (684)    506.2     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|IITRI              058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302306  07/11/97   729       50(3)      37  (693)    510.6     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   732      100(5)      75  (705)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(5)      30  (683)    350.8     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   728       50(5)      30  (672)    327.2     ELMIRON                                    |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   735      100(5)      70  (706)    344.4     TRANS-CINNAMALDEHYDE                       |
|BATTELLE NORTHWEST 059302607  08/14/97   734       50( )      32  (700)    345.9     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|IITRI              058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302306  07/11/97   732       50(5)      37  (699)    314.6     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       97/100(97%)   47/50 (94%)   49/50 (98%)         78/100(78%)   44/50 (88%)   37/50 (74%)    |
|                                       47/50 (94%)   42/50 (84%)   47/50 (94%)         35/50 (70%)   37/50 (74%)   42/50 (84%)    |
|                                       99/100(99%)   47/50 (94%)   47/50 (94%)         78/100(78%)   46/50 (92%)   44/50 (88%)    |
|                                       46/49 (94%)   48/50 (96%)   99/100(99%)         38/49 (78%)   41/50 (82%)   92/100(92%)    |
|                                       48/50 (96%)   60/60 (100%)  49/50 (98%)         45/50 (90%)   47/60 (78%)   33/50 (66%)    |
|                                                                                       45/50 (90%)                                |
| Overall Incidence               Total 872/909 (95.93%)Mean 95.39%  SD 3.84%     Total 782/959 (81.54%) Mean 81.37%  SD 8.13%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    76/100(76%)   35/50 (70%)   29/50 (58%)         30/100(30%)   25/50 (50%)   12/50 (24%)    |
|                                       29/50 (58%)   34/50 (68%)   30/50 (60%)         26/50 (52%)   16/50 (32%)   23/50 (46%)    |
|                                       57/100(57%)   27/50 (54%)   26/50 (52%)         39/100(39%)   25/50 (50%)   25/50 (50%)    |
|                                       34/49 (69%)   28/50 (56%)   66/100(66%)         26/49 (53%)   28/50 (56%)   40/100(40%)    |
|                                       21/50 (42%)   37/60 (62%)   33/50 (66%)         18/50 (36%)   24/60 (40%)   22/50 (44%)    |
|                                                                                       20/50 (40%)                                |
| Overall Incidence               Total 562/909 (61.83%)Mean 60.94%  SD 8.56%     Total 399/959 (41.61%) Mean 42.63%  SD 9.13%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         99/100(99%)   49/50 (98%)   49/50 (98%)         92/100(92%)   50/50 (100%)  42/50 (84%)    |
|                                       49/50 (98%)   49/50 (98%)   49/50 (98%)         45/50 (90%)   43/50 (86%)   45/50 (90%)    |
|                                      100/100(100%)  49/50 (98%)   49/50 (98%)         92/100(92%)   49/50 (98%)   49/50 (98%)    |
|                                       48/49 (98%)   50/50 (100%) 100/100(100%)        44/49 (90%)   47/50 (94%)   98/100(98%)    |
|                                       50/50 (100%)  60/60 (100%)  50/50 (100%)        47/50 (94%)   54/60 (90%)   43/50 (86%)    |
|                                                                                       47/50 (94%)                                |
| Overall Incidence               Total 900/909 (99.01%)Mean 98.86%  SD 0.99%     Total 887/959 (92.49%) Mean 92.24%  SD 4.73%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.33%   SD 1.05%     Total 4/959 (0.42%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.38%   SD 0.79%     Total 3/959 (0.31%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           2/49 (4%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 6/909 (0.66%)   Mean 0.71%   SD 1.2%      Total 7/959 (0.73%)    Mean 0.76%   SD 1.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     1/50 (2%)     0/100(0%)     |
|                                        1/50 (2%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.24%   SD 0.65%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   68/100(68%)   16/50 (32%)   15/50 (30%)         24/100(24%)   10/50 (20%)    7/50 (14%)    |
|      Mononuclear, or Undifferentiated 20/50 (40%)   27/50 (54%)   17/50 (34%)         21/50 (42%)    8/50 (16%)   15/50 (30%)    |
|                                       40/100(40%)   19/50 (38%)   16/50 (32%)         21/100(21%)   11/50 (22%)   14/50 (28%)    |
|                                       26/49 (53%)   22/50 (44%)   50/100(50%)         16/49 (33%)   21/50 (42%)   20/100(20%)    |
|                                       11/50 (22%)   30/60 (50%)   24/50 (48%)         10/50 (20%)   21/60 (35%)   13/50 (26%)    |
|                                                                                       12/50 (24%)                                |
| Overall Incidence               Total 401/909 (44.11%)Mean 42.34%  SD 11.77%    Total 244/959 (25.44%) Mean 26.04%  SD 8.4%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.4%    SD 1.12%     Total 2/959 (0.21%)    Mean 0.13%   SD 0.34%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.41%   SD 1.14%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)     6/50 (12%)    2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)     1/50 (2%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     1/50 (2%)     4/100(4%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 43/909 (4.73%)  Mean 4.83%   SD 3.11%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)     6/50 (12%)    2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)     1/50 (2%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     4/100(4%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 41/909 (4.51%)  Mean 4.56%   SD 3.35%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 1.05%   SD 1.66%     Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 1.05%   SD 1.66%     Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/100(2%)     0/47 (0%)     0/50 (0%)           2/100(2%)     1/49 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     1/49 (2%)     |
|                                        2/49 (4%)     0/50 (0%)     0/99 (0%)           1/49 (2%)     0/49 (0%)     6/100(6%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     2/60 (3%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 6/905 (0.66%)   Mean 0.67%   SD 1.25%     Total 21/956 (2.2%)    Mean 2.03%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/49 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/905 (0%)      Mean 0%      SD 0%        Total 2/956 (0.21%)    Mean 0.19%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/100(0%)     1/47 (2%)     0/50 (0%)           0/99 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/49 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/903 (0.22%)   Mean 0.21%   SD 0.59%     Total 0/950 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             10/100(10%)    4/47 (9%)     7/50 (14%)          3/99 (3%)     0/49 (0%)     2/50 (4%)     |
|                                        3/50 (6%)     4/50 (8%)     6/50 (12%)          1/50 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        5/100(5%)     7/49 (14%)   10/50 (20%)          1/100(1%)     1/50 (2%)     2/50 (4%)     |
|                                        4/49 (8%)     4/50 (8%)    24/98 (24%)          3/48 (6%)     2/49 (4%)     7/96 (7%)     |
|                                        7/50 (14%)    2/60 (3%)     3/50 (6%)           1/50 (2%)     2/60 (3%)     2/49 (4%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 100/903 (11.07%)Mean 10.79%  SD 5.79%     Total 34/950 (3.58%)   Mean 3.57%   SD 2.18%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             1/100(1%)     0/47 (0%)     0/50 (0%)           0/99 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/49 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/49 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/903 (0.11%)   Mean 0.07%   SD 0.26%     Total 1/950 (0.11%)    Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/100(0%)     5/47 (11%)    1/50 (2%)           0/99 (0%)     2/49 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     2/49 (4%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/98 (2%)           0/48 (0%)     0/49 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     2/60 (3%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 18/903 (1.99%)  Mean 2.28%   SD 2.72%     Total 7/950 (0.74%)    Mean 0.76%   SD 1.25%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           11/100(11%)    9/47 (19%)    7/50 (14%)          3/99 (3%)     2/49 (4%)     3/50 (6%)     |
|      Complex, Malignant, NOS           4/50 (8%)     6/50 (12%)    7/50 (14%)          1/50 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        5/100(5%)     8/49 (16%)   10/50 (20%)          4/100(4%)     1/50 (2%)     2/50 (4%)     |
|                                        5/49 (10%)    5/50 (10%)   26/98 (27%)          3/48 (6%)     2/49 (4%)     7/96 (7%)     |
|                                        7/50 (14%)    4/60 (7%)     3/50 (6%)           2/50 (4%)     2/60 (3%)     2/49 (4%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 117/903 (12.96%)Mean 12.86%  SD 5.88%     Total 42/950 (4.42%)   Mean 4.38%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 1.05%   SD 1.66%     Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 1.05%   SD 1.66%     Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 6/959 (0.63%)    Mean 0.63%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     2/100(2%)           0/49 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.7%      Total 9/959 (0.94%)    Mean 0.94%   SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              7/100(7%)     3/50 (6%)     1/50 (2%)          15/98 (15%)    6/48 (13%)    3/50 (6%)     |
|                                        2/50 (4%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/47 (2%)     8/46 (17%)    |
|                                        7/100(7%)     0/50 (0%)     1/50 (2%)           4/99 (4%)     8/48 (17%)    5/49 (10%)    |
|                                        3/48 (6%)     0/50 (0%)    13/100(13%)          4/49 (8%)     2/50 (4%)    11/90 (12%)    |
|                                        1/49 (2%)     2/60 (3%)     2/50 (4%)           5/50 (10%)   12/59 (20%)    7/50 (14%)    |
|                                                                                        7/49 (14%)                                |
| Overall Incidence               Total 45/907 (4.96%)  Mean 4.17%   SD 3.5%      Total 100/931 (10.74%) Mean 10.71%  SD 5.54%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/100(1%)     3/50 (6%)     1/50 (2%)           1/98 (1%)     5/48 (10%)    0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     5/50 (10%)          1/49 (2%)     0/47 (0%)     2/46 (4%)     |
|                                        4/100(4%)     0/50 (0%)     2/50 (4%)           9/99 (9%)     1/48 (2%)     0/49 (0%)     |
|                                        3/48 (6%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/90 (0%)     |
|                                        3/49 (6%)     2/60 (3%)     2/50 (4%)           2/50 (4%)     2/59 (3%)     2/50 (4%)     |
|                                                                                        3/49 (6%)                                 |
| Overall Incidence               Total 27/907 (2.98%)  Mean 3.25%   SD 2.96%     Total 28/931 (3.01%)   Mean 2.91%   SD 3.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/100(8%)     6/50 (12%)    2/50 (4%)          16/98 (16%)   10/48 (21%)    3/50 (6%)     |
|                                        3/50 (6%)     3/50 (6%)     5/50 (10%)          3/49 (6%)     1/47 (2%)    10/46 (22%)    |
|                                       11/100(11%)    0/50 (0%)     3/50 (6%)          13/99 (13%)    9/48 (19%)    5/49 (10%)    |
|                                        6/48 (13%)    0/50 (0%)    13/100(13%)          4/49 (8%)     2/50 (4%)    11/90 (12%)    |
|                                        4/49 (8%)     4/60 (7%)     4/50 (8%)           7/50 (14%)   14/59 (24%)    8/50 (16%)    |
|                                                                                       10/49 (20%)                                |
| Overall Incidence               Total 72/907 (7.94%)  Mean 7.42%   SD 4.03%     Total 126/931 (13.53%) Mean 13.36%  SD 6.77%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/90 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 0/907 (0%)      Mean 0%      SD 0%        Total 1/931 (0.11%)    Mean 0.13%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/90 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 1/907 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/931 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/90 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 1/907 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/931 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.4%    SD 1.12%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/100(2%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 5/909 (0.55%)   Mean 0.4%    SD 0.83%     Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.38%   SD 0.79%     Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)     2/44 (5%)     1/50 (2%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     3/50 (6%)     1/50 (2%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/49 (4%)     1/50 (2%)     3/99 (3%)           1/49 (2%)     1/49 (2%)     1/100(1%)     |
|                                        4/50 (8%)     2/60 (3%)     3/50 (6%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 31/901 (3.44%)  Mean 3.6%    SD 2.51%     Total 9/955 (0.94%)    Mean 1.05%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/99 (0%)     0/44 (0%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     4/50 (8%)     2/50 (4%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        4/49 (8%)     1/50 (2%)     1/99 (1%)           1/49 (2%)     1/49 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 16/901 (1.78%)  Mean 2.08%   SD 2.81%     Total 6/955 (0.63%)    Mean 0.57%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)     2/44 (5%)     1/50 (2%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     7/50 (14%)    3/50 (6%)           2/100(2%)     2/50 (4%)     1/50 (2%)     |
|                                        6/49 (12%)    2/50 (4%)     4/99 (4%)           2/49 (4%)     2/49 (4%)     2/100(2%)     |
|                                        4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 47/901 (5.22%)  Mean 5.68%   SD 4.2%      Total 15/955 (1.57%)   Mean 1.61%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/906 (0.22%)   Mean 0.27%   SD 0.71%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/906 (0.22%)   Mean 0.27%   SD 0.71%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)     1/47 (2%)     0/50 (0%)           1/100(1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/906 (0.33%)   Mean 0.41%   SD 0.85%     Total 1/957 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)     0/47 (0%)     0/50 (0%)           1/100(1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           1/48 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/906 (0%)      Mean 0%      SD 0%        Total 3/957 (0.31%)    Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)     1/47 (2%)     0/50 (0%)           2/100(2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           1/48 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/906 (0.33%)   Mean 0.41%   SD 0.85%     Total 4/957 (0.42%)    Mean 0.38%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/906 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/906 (0%)      Mean 0%      SD 0%        Total 1/957 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/906 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)     1/47 (2%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/48 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/906 (0.11%)   Mean 0.14%   SD 0.55%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     1/100(1%)           0/49 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 7/909 (0.77%)   Mean 0.69%   SD 1.11%     Total 4/959 (0.42%)    Mean 0.48%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 5/909 (0.55%)   Mean 0.65%   SD 1.21%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatoblastoma                    0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 5/909 (0.55%)   Mean 0.65%   SD 1.21%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma            1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     1/100(1%)           0/49 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     3/60 (5%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 12/909 (1.32%)  Mean 1.34%   SD 1.77%     Total 5/959 (0.52%)    Mean 0.6%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma, or        1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     1/100(1%)           0/49 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     3/60 (5%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 12/909 (1.32%)  Mean 1.34%   SD 1.77%     Total 5/959 (0.52%)    Mean 0.6%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/49 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/958 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)     2/50 (4%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        4/100(4%)     1/50 (2%)     6/50 (12%)          6/100(6%)     1/50 (2%)     0/50 (0%)     |
|                                        2/49 (4%)     4/50 (8%)     3/100(3%)           1/49 (2%)     0/49 (0%)     3/100(3%)     |
|                                        1/50 (2%)     1/60 (2%)     1/50 (2%)           3/50 (6%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 32/909 (3.52%)  Mean 3.58%   SD 3.03%     Total 22/958 (2.3%)    Mean 2.04%   SD 2.32%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)     1/50 (2%)     2/50 (4%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     1/50 (2%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     1/100(1%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 7/909 (0.77%)   Mean 0.84%   SD 1.23%     Total 6/958 (0.63%)    Mean 0.56%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)     3/50 (6%)     2/50 (4%)           3/100(3%)     1/50 (2%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        5/100(5%)     2/50 (4%)     7/50 (14%)          7/100(7%)     2/50 (4%)     1/50 (2%)     |
|                                        2/49 (4%)     4/50 (8%)     3/100(3%)           1/49 (2%)     0/49 (0%)     4/100(4%)     |
|                                        1/50 (2%)     2/60 (3%)     1/50 (2%)           3/50 (6%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 39/909 (4.29%)  Mean 4.43%   SD 3.22%     Total 28/958 (2.92%)   Mean 2.61%   SD 2.37%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/958 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/958 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.33%   SD 0.72%     Total 10/959 (1.04%)   Mean 1.13%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     4/50 (8%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     5/50 (10%)    0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           3/49 (6%)     2/50 (4%)     2/100(2%)     |
|                                        2/50 (4%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 6/909 (0.66%)   Mean 0.67%   SD 1.24%     Total 28/959 (2.92%)   Mean 3.32%   SD 2.95%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 3/100(3%)     0/50 (0%)     1/50 (2%)           0/100(0%)     4/50 (8%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     2/50 (4%)     |
|                                        0/100(0%)     2/50 (4%)     0/50 (0%)           2/100(2%)     5/50 (10%)    0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           3/49 (6%)     3/50 (6%)     3/100(3%)     |
|                                        2/50 (4%)     0/60 (0%)     0/50 (0%)           3/50 (6%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence               Total 9/909 (0.99%)   Mean 1%      SD 1.56%     Total 35/959 (3.65%)   Mean 4.07%   SD 2.98%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         8/100(8%)     1/50 (2%)     2/50 (4%)          53/100(53%)   36/50 (72%)   15/50 (30%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)          21/50 (42%)   15/50 (30%)   21/50 (42%)    |
|                                        3/100(3%)     2/50 (4%)     2/50 (4%)          55/100(55%)   25/50 (50%)   20/50 (40%)    |
|                                        0/49 (0%)     2/50 (4%)     6/100(6%)          17/49 (35%)   16/50 (32%)   56/100(56%)    |
|                                        3/50 (6%)     0/60 (0%)     0/50 (0%)          22/50 (44%)   23/60 (38%)   14/50 (28%)    |
|                                                                                       28/50 (56%)                                |
| Overall Incidence               Total 37/909 (4.07%)  Mean 3.8%    SD 2.46%     Total 437/959 (45.57%) Mean 43.94%  SD 12.23%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     9/100(9%)     1/50 (2%)     4/50 (8%)          53/100(53%)   36/50 (72%)   15/50 (30%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)          21/50 (42%)   16/50 (32%)   23/50 (46%)    |
|                                        3/100(3%)     3/50 (6%)     2/50 (4%)          55/100(55%)   25/50 (50%)   20/50 (40%)    |
|                                        0/49 (0%)     2/50 (4%)     6/100(6%)          17/49 (35%)   17/50 (34%)   56/100(56%)    |
|                                        3/50 (6%)     0/60 (0%)     0/50 (0%)          23/50 (46%)   23/60 (38%)   14/50 (28%)    |
|                                                                                       28/50 (56%)                                |
| Overall Incidence               Total 41/909 (4.51%)  Mean 4.27%   SD 2.84%     Total 442/959 (46.09%) Mean 44.56%  SD 11.97%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,   11/100(11%)    1/50 (2%)     4/50 (8%)          53/100(53%)   37/50 (74%)   16/50 (32%)    |
|      or Adenoma                        2/50 (4%)     3/50 (6%)     3/50 (6%)          23/50 (46%)   16/50 (32%)   23/50 (46%)    |
|                                        3/100(3%)     4/50 (8%)     2/50 (4%)          56/100(56%)   29/50 (58%)   20/50 (40%)    |
|                                        1/49 (2%)     2/50 (4%)     6/100(6%)          18/49 (37%)   19/50 (38%)   58/100(58%)    |
|                                        5/50 (10%)    0/60 (0%)     0/50 (0%)          24/50 (48%)   23/60 (38%)   14/50 (28%)    |
|                                                                                       30/50 (60%)                                |
| Overall Incidence               Total 47/909 (5.17%)  Mean 4.94%   SD 3.35%     Total 459/959 (47.86%) Mean 46.5%   SD 12.59%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.27%   SD 0.71%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/46 (0%)     0/50 (0%)           1/100(1%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/903 (0%)      Mean 0%      SD 0%        Total 1/957 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/49 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/100(0%)           0/49 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/903 (0.11%)   Mean 0.13%   SD 0.52%     Total 1/957 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 4/909 (0.44%)   Mean 0.4%    SD 0.74%     Total 4/959 (0.42%)    Mean 0.44%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.13%   SD 0.35%     Total 5/959 (0.52%)    Mean 0.63%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             2/100(2%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     3/50 (6%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 6/909 (0.66%)   Mean 0.53%   SD 0.92%     Total 9/959 (0.94%)    Mean 1.06%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.13%   SD 0.35%     Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.27%   SD 0.7%      Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.06%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/49 (4%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/959 (0.31%)    Mean 0.38%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        2/49 (4%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/959 (0.42%)    Mean 0.51%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/959 (0.21%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     3/100(3%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/959 (0.31%)    Mean 0.19%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              2/100(2%)     0/44 (0%)     0/50 (0%)           0/100(0%)     1/47 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     3/98 (3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                       10/50 (20%)    1/60 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 21/901 (2.33%)  Mean 2.38%   SD 5.04%     Total 4/956 (0.42%)    Mean 0.51%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/100(0%)     1/44 (2%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/901 (0.22%)   Mean 0.28%   SD 0.75%     Total 0/956 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 2/100(2%)     1/44 (2%)     0/50 (0%)           0/100(0%)     1/47 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     3/98 (3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                       10/50 (20%)    1/60 (2%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 23/901 (2.55%)  Mean 2.67%   SD 4.95%     Total 4/956 (0.42%)    Mean 0.51%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              1/100(1%)     0/44 (0%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/901 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/956 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/100(0%)     2/44 (5%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/901 (0.33%)   Mean 0.37%   SD 1.18%     Total 0/956 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/93 (0%)     1/45 (2%)     0/46 (0%)           2/86 (2%)     0/49 (0%)     1/46 (2%)     |
|                                        0/46 (0%)     0/46 (0%)     0/45 (0%)           1/48 (2%)     0/45 (0%)     0/46 (0%)     |
|                                        0/92 (0%)     0/49 (0%)     1/44 (2%)           0/90 (0%)     0/49 (0%)     0/40 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/85 (0%)           0/42 (0%)     0/45 (0%)     1/88 (1%)     |
|                                        0/50 (0%)     0/58 (0%)     0/48 (0%)           0/49 (0%)     0/57 (0%)     0/46 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence               Total 2/841 (0.24%)   Mean 0.3%    SD 0.79%     Total 5/874 (0.57%)    Mean 0.48%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   15/47 (32%)   19/50 (38%)         29/100(29%)   20/48 (42%)   21/50 (42%)    |
|   Adenoma                             17/50 (34%)   11/50 (22%)   13/50 (26%)         12/50 (24%)   23/50 (46%)   24/50 (48%)    |
|                                       21/100(21%)   27/50 (54%)   36/49 (73%)         35/100(35%)   34/50 (68%)   30/50 (60%)    |
|                                       31/49 (63%)   35/50 (70%)   34/98 (35%)         23/49 (47%)   31/49 (63%)   61/99 (62%)    |
|                                       12/50 (24%)   11/59 (19%)   15/48 (31%)         19/50 (38%)   19/59 (32%)   15/50 (30%)    |
|                                                                                       27/50 (54%)                                |
| Overall Incidence               Total 314/900 (34.89%)Mean 37.28%  SD 18.86%    Total 423/954 (44.34%) Mean 44.98%  SD 13.45%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/100(0%)     0/47 (0%)     1/50 (2%)           0/100(0%)     1/48 (2%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/49 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/49 (0%)     3/99 (3%)     |
|                                        0/50 (0%)     0/59 (0%)     1/48 (2%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/900 (0.33%)   Mean 0.41%   SD 0.85%     Total 5/954 (0.52%)    Mean 0.44%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   15/47 (32%)   20/50 (40%)         29/100(29%)   21/48 (44%)   21/50 (42%)    |
|   Carcinoma or Adenoma                17/50 (34%)   11/50 (22%)   13/50 (26%)         13/50 (26%)   23/50 (46%)   24/50 (48%)    |
|                                       21/100(21%)   27/50 (54%)   37/49 (76%)         35/100(35%)   34/50 (68%)   30/50 (60%)    |
|                                       31/49 (63%)   35/50 (70%)   34/98 (35%)         23/49 (47%)   31/49 (63%)   64/99 (65%)    |
|                                       12/50 (24%)   11/59 (19%)   16/48 (33%)         19/50 (38%)   19/59 (32%)   15/50 (30%)    |
|                                                                                       27/50 (54%)                                |
| Overall Incidence               Total 317/900 (35.22%)Mean 37.69%  SD 19.11%    Total 428/954 (44.86%) Mean 45.43%  SD 13.49%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/100(1%)     0/47 (0%)     1/50 (2%)           2/100(2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/49 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/59 (0%)     0/48 (0%)           1/50 (2%)     1/59 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/900 (0.22%)   Mean 0.2%    SD 0.56%     Total 4/954 (0.42%)    Mean 0.36%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/100(1%)     0/47 (0%)     1/50 (2%)           2/100(2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/49 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/49 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/59 (0%)     0/48 (0%)           1/50 (2%)     1/59 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/900 (0.22%)   Mean 0.2%    SD 0.56%     Total 4/954 (0.42%)    Mean 0.36%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)     1/48 (2%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        4/100(4%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        2/49 (4%)     2/60 (3%)     2/50 (4%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 13/906 (1.43%)  Mean 1.43%   SD 1.72%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)     1/48 (2%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        4/100(4%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        2/49 (4%)     2/60 (3%)     2/50 (4%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 13/906 (1.43%)  Mean 1.43%   SD 1.72%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/906 (0%)      Mean 0%      SD 0%        Total 1/957 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/906 (0%)      Mean 0%      SD 0%        Total 1/957 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/100(0%)     0/49 (0%)     1/50 (2%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 7/906 (0.77%)   Mean 0.93%   SD 1.49%     Total 0/957 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 2/959 (0.21%)    Mean 0.17%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 4/909 (0.44%)   Mean 0.54%   SD 0.92%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 5/909 (0.55%)   Mean 0.6%    SD 0.91%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     3/100(3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 11/909 (1.21%)  Mean 1.09%   SD 1.2%      Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     3/100(3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 11/909 (1.21%)  Mean 1.09%   SD 1.2%      Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Tumor Benign, or                  0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Trichoepithelioma                 2/100(2%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     3/100(3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 15/909 (1.65%)  Mean 1.49%   SD 1.39%     Total 3/959 (0.31%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.2%    SD 0.56%     Total 3/959 (0.31%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      NOS)                              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.2%    SD 0.56%     Total 3/959 (0.31%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|      (benign, malignant or NOS), or    3/100(3%)     1/50 (2%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/49 (0%)     0/50 (0%)     3/100(3%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 17/909 (1.87%)  Mean 1.69%   SD 1.37%     Total 6/959 (0.63%)    Mean 0.75%   SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/100(11%)    1/50 (2%)     4/50 (8%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    2/50 (4%)     6/50 (12%)    3/50 (6%)           2/50 (4%)     0/50 (0%)     3/50 (6%)     |
|      B), Basal Cell Adenoma, Adenoma,  8/100(8%)     3/50 (6%)     2/50 (4%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma, Sq Papilloma,          4/49 (8%)     5/50 (10%)   14/100(14%)          1/49 (2%)     0/50 (0%)     1/100(1%)     |
|      Keratoacanthoma,                  5/50 (10%)    7/60 (12%)    4/50 (8%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                 1/50 (2%)                                 |
| Overall Incidence               Total 79/909 (8.69%)  Mean 8.19%   SD 3.36%     Total 13/959 (1.36%)   Mean 1.5%    SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.27%   SD 1.03%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.38%   SD 0.79%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      8/100(8%)     1/50 (2%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)     1/50 (2%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/49 (8%)     4/50 (8%)    10/100(10%)          0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     5/60 (8%)     2/50 (4%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 53/909 (5.83%)  Mean 5.43%   SD 2.6%      Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)     1/50 (2%)     1/50 (2%)           2/100(2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     2/50 (4%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 11/909 (1.21%)  Mean 1.4%    SD 1.18%     Total 6/959 (0.63%)    Mean 0.63%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.27%   SD 0.7%      Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Tumor (malignant or NOS), or      1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|      Carcinoma                         0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.33%   SD 0.72%     Total 5/959 (0.52%)    Mean 0.63%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     1/100(1%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 0.93%   SD 0.96%     Total 3/959 (0.31%)    Mean 0.32%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     1/100(1%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 8/909 (0.88%)   Mean 0.93%   SD 0.96%     Total 3/959 (0.31%)    Mean 0.32%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     1/50 (2%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     4/50 (8%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma or Keratoacanthoma      5/100(5%)     2/50 (4%)     2/50 (4%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        4/49 (8%)     5/50 (10%)   11/100(11%)          1/49 (2%)     0/50 (0%)     1/100(1%)     |
|                                        4/50 (8%)     5/60 (8%)     3/50 (6%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 62/909 (6.82%)  Mean 6.5%    SD 2.64%     Total 7/959 (0.73%)    Mean 0.75%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     1/50 (2%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     1/50 (2%)     4/50 (8%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)     2/50 (4%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/49 (8%)     5/50 (10%)   11/100(11%)          1/49 (2%)     0/50 (0%)     1/100(1%)     |
|                                        4/50 (8%)     5/60 (8%)     3/50 (6%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 61/909 (6.71%)  Mean 6.37%   SD 2.82%     Total 5/959 (0.52%)    Mean 0.5%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 4/909 (0.44%)   Mean 0.4%    SD 0.74%     Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/100(2%)     6/50 (12%)    1/50 (2%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        7/100(7%)     2/50 (4%)     1/50 (2%)           1/100(1%)     0/50 (0%)     3/50 (6%)     |
|                                        5/49 (10%)    2/50 (4%)    12/100(12%)          0/49 (0%)     1/50 (2%)     4/100(4%)     |
|                                        4/50 (8%)     5/60 (8%)     1/50 (2%)           2/50 (4%)     3/60 (5%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 53/909 (5.83%)  Mean 5.57%   SD 3.87%     Total 19/959 (1.98%)   Mean 1.94%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      8/100(8%)     9/50 (18%)    3/50 (6%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Histiocytoma                     12/100(12%)    4/50 (8%)     2/50 (4%)           1/100(1%)     2/50 (4%)     3/50 (6%)     |
|                                        7/49 (14%)    6/50 (12%)   13/100(13%)          1/49 (2%)     1/50 (2%)     6/100(6%)     |
|                                        7/50 (14%)    5/60 (8%)     2/50 (4%)           2/50 (4%)     3/60 (5%)     2/50 (4%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence               Total 86/909 (9.46%)  Mean 9.17%   SD 4.53%     Total 29/959 (3.02%)   Mean 3.07%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/100(2%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        6/100(6%)     2/50 (4%)     1/50 (2%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/49 (4%)     1/50 (2%)     1/100(1%)           0/49 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 21/909 (2.31%)  Mean 2.21%   SD 2.15%     Total 5/959 (0.52%)    Mean 0.56%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               5/100(5%)     3/50 (6%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Histiocytoma                      6/100(6%)     2/50 (4%)     1/50 (2%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|                                        2/49 (4%)     4/50 (8%)     1/100(1%)           1/49 (2%)     0/50 (0%)     2/100(2%)     |
|                                        3/50 (6%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     2/50 (4%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 33/909 (3.63%)  Mean 3.61%   SD 2.39%     Total 10/959 (1.04%)   Mean 1.13%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 6/909 (0.66%)   Mean 0.67%   SD 1.23%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.7%      Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.7%      Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/100(0%)           1/49 (2%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 6/909 (0.66%)   Mean 0.73%   SD 1.62%     Total 4/959 (0.42%)    Mean 0.44%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.7%      Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/43 (0%)     0/50 (0%)           0/100(0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           1/49 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 1/957 (0.1%)     Mean 0.13%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.59%     Total 2/959 (0.21%)    Mean 0.25%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/909 (0.33%)   Mean 0.27%   SD 0.59%     Total 2/959 (0.21%)    Mean 0.25%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.27%   SD 0.7%      Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             96/100(96%)   45/50 (90%)   44/50 (88%)                                                    |
|                                       40/50 (80%)   41/50 (82%)   47/50 (94%)                                                    |
|                                       91/100(91%)   40/50 (80%)   40/50 (80%)                                                    |
|                                       38/49 (78%)   36/50 (72%)   93/100(93%)                                                    |
|                                       41/50 (82%)   55/60 (92%)   49/50 (98%)                                                    |
|                                                                                                                                  |
| Overall Incidence               Total 796/909 (87.57%)Mean 86.35%  SD 7.74%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     1/48 (2%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/87 (1%)     0/50 (0%)     0/47 (0%)           0/92 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     2/97 (2%)           0/46 (0%)     0/49 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence               Total 3/858 (0.35%)   Mean 0.21%   SD 0.59%     Total 1/908 (0.11%)    Mean 0.13%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/87 (0%)     0/50 (0%)     0/47 (0%)           1/92 (1%)     0/48 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/97 (0%)           0/46 (0%)     0/49 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence               Total 0/858 (0%)      Mean 0%      SD 0%        Total 2/908 (0.22%)    Mean 0.2%    SD 0.57%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     1/48 (2%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/87 (1%)     0/50 (0%)     0/47 (0%)           1/92 (1%)     0/48 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     2/97 (2%)           0/46 (0%)     0/49 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence               Total 3/858 (0.35%)   Mean 0.21%   SD 0.59%     Total 3/908 (0.33%)    Mean 0.33%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             12/100(12%)    4/42 (10%)    8/50 (16%)         21/100(21%)    6/45 (13%)   11/50 (22%)    |
|                                        9/50 (18%)    8/50 (16%)   12/50 (24%)          3/50 (6%)     5/50 (10%)    7/50 (14%)    |
|                                       12/100(12%)    7/50 (14%)    5/49 (10%)         11/100(11%)    5/50 (10%)    6/47 (13%)    |
|                                        9/46 (20%)    1/50 (2%)    15/99 (15%)          4/47 (9%)     2/50 (4%)    15/100(15%)    |
|                                        4/50 (8%)    10/59 (17%)   11/50 (22%)         12/50 (24%)    9/60 (15%)    6/50 (12%)    |
|                                                                                        2/49 (4%)                                 |
| Overall Incidence               Total 127/895 (14.19%)Mean 14.36%  SD 5.67%     Total 125/948 (13.19%) Mean 12.67%  SD 5.92%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            4/100(4%)     2/42 (5%)     2/50 (4%)           0/100(0%)     1/45 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        3/100(3%)     0/50 (0%)     1/49 (2%)           3/100(3%)     3/50 (6%)     3/47 (6%)     |
|                                        1/46 (2%)     0/50 (0%)     1/99 (1%)           3/47 (6%)     1/50 (2%)     5/100(5%)     |
|                                        1/50 (2%)     0/59 (0%)     0/50 (0%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/49 (2%)                                 |
| Overall Incidence               Total 18/895 (2.01%)  Mean 1.93%   SD 1.72%     Total 28/948 (2.95%)   Mean 3.04%   SD 2.18%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/100(16%)    6/42 (14%)   10/50 (20%)         21/100(21%)    7/45 (16%)   11/50 (22%)    |
|                                       10/50 (20%)    8/50 (16%)   14/50 (28%)          5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|                                       15/100(15%)    7/50 (14%)    6/49 (12%)         14/100(14%)    8/50 (16%)    8/47 (17%)    |
|                                       10/46 (22%)    1/50 (2%)    16/99 (16%)          7/47 (15%)    3/50 (6%)    19/100(19%)    |
|                                        5/50 (10%)   10/59 (17%)   11/50 (22%)         13/50 (26%)   10/60 (17%)    6/50 (12%)    |
|                                                                                        3/49 (6%)                                 |
| Overall Incidence               Total 145/895 (16.2%) Mean 16.29%  SD 5.97%     Total 151/948 (15.93%) Mean 15.52%  SD 5.36%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/100(3%)     1/42 (2%)     0/50 (0%)           0/100(0%)     0/45 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/100(1%)     0/50 (0%)     0/49 (0%)           1/100(1%)     0/50 (0%)     0/47 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     1/99 (1%)           0/47 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/59 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 8/895 (0.89%)   Mean 0.76%   SD 1.07%     Total 3/948 (0.32%)    Mean 0.31%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/100(1%)     0/42 (0%)     2/50 (4%)           1/100(1%)     1/45 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        3/100(3%)     0/50 (0%)     0/49 (0%)           0/100(0%)     0/50 (0%)     1/47 (2%)     |
|                                        0/46 (0%)     0/50 (0%)     0/99 (0%)           1/47 (2%)     2/50 (4%)     0/100(0%)     |
|                                        1/50 (2%)     1/59 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 9/895 (1.01%)   Mean 0.91%   SD 1.32%     Total 11/948 (1.16%)   Mean 1.34%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 4/100(4%)     1/42 (2%)     2/50 (4%)           1/100(1%)     1/45 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        4/100(4%)     0/50 (0%)     0/49 (0%)           1/100(1%)     0/50 (0%)     1/47 (2%)     |
|                                        0/46 (0%)     0/50 (0%)     1/99 (1%)           1/47 (2%)     2/50 (4%)     0/100(0%)     |
|                                        1/50 (2%)     1/59 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 17/895 (1.9%)   Mean 1.67%   SD 1.68%     Total 14/948 (1.48%)   Mean 1.65%   SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.07%   SD 0.26%     Total 0/959 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 3/959 (0.31%)    Mean 0.38%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.13%   SD 0.35%     Total 5/959 (0.52%)    Mean 0.56%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/909 (0.22%)   Mean 0.13%   SD 0.35%     Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/909 (0%)      Mean 0%      SD 0%        Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/99 (0%)           0/48 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/901 (0%)      Mean 0%      SD 0%        Total 1/956 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/99 (1%)           1/48 (2%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 4/901 (0.44%)   Mean 0.45%   SD 0.81%     Total 4/956 (0.42%)    Mean 0.51%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/99 (1%)           1/48 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 4/901 (0.44%)   Mean 0.45%   SD 0.81%     Total 3/956 (0.31%)    Mean 0.38%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/100(0%)     1/46 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/99 (0%)           0/48 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/901 (0.11%)   Mean 0.14%   SD 0.56%     Total 0/956 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 4/959 (0.42%)    Mean 0.5%    SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/959 (0.21%)    Mean 0.19%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     2/100(2%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/959 (0.31%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       19/100(19%)    8/50 (16%)    7/50 (14%)    |
|                                                                                        7/50 (14%)   10/50 (20%)    7/50 (14%)    |
|                                                                                       14/100(14%)    7/50 (14%)   10/50 (20%)    |
|                                                                                       15/49 (31%)    6/50 (12%)   13/100(13%)    |
|                                                                                       14/50 (28%)   11/60 (18%)    6/50 (12%)    |
|                                                                                       11/50 (22%)                                |
| Overall Incidence                                                               Total 165/959 (17.21%) Mean 17.56%  SD 5.55%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/959 (0.21%)    Mean 0.25%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    19/100(19%)    9/50 (18%)    7/50 (14%)    |
|                                                                                        7/50 (14%)   11/50 (22%)    7/50 (14%)    |
|                                                                                       14/100(14%)    7/50 (14%)   10/50 (20%)    |
|                                                                                       15/49 (31%)    6/50 (12%)   13/100(13%)    |
|                                                                                       14/50 (28%)   11/60 (18%)    6/50 (12%)    |
|                                                                                       11/50 (22%)                                |
| Overall Incidence                                                               Total 167/959 (17.41%) Mean 17.81%  SD 5.61%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     3/100(3%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/959 (0.42%)    Mean 0.31%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.1%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/959 (0.1%)     Mean 0.13%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/909 (0.11%)   Mean 0.13%   SD 0.52%     Total 3/959 (0.31%)    Mean 0.29%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           2/49 (4%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 10/909 (1.1%)   Mean 1.2%    SD 1.78%     Total 4/959 (0.42%)    Mean 0.48%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/100(1%)           2/49 (4%)     0/50 (0%)     0/100(0%)     |
|                                        2/50 (4%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     2/60 (3%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 11/909 (1.21%)  Mean 1.33%   SD 1.91%     Total 7/959 (0.73%)    Mean 0.78%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
