                                                 Toxicology Data Management System                                     Page: 1
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   28/50 (56%)                       22/50 (44%)   13/50 (26%)                  |
| Overall Incidence               Total 55/100 (55%)    Mean 55%     SD 1.41%     Total 35/100 (35%)     Mean 35%     SD 12.73%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   27/50 (54%)                       18/50 (36%)   12/50 (24%)                  |
| Overall Incidence               Total 46/100 (46%)    Mean 46%     SD 11.31%    Total 30/100 (30%)     Mean 30%     SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         39/50 (78%)   40/50 (80%)                       32/50 (64%)   21/50 (42%)                  |
| Overall Incidence               Total 79/100 (79%)    Mean 79%     SD 1.41%     Total 53/100 (53%)     Mean 53%     SD 15.56%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     7/50 (14%)                        3/50 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 9.9%      Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     7/50 (14%)                        5/50 (10%)    1/50 (2%)                   |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 7.07%     Total 6/100 (6%)       Mean 6%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     1/50 (2%)                         5/50 (10%)    7/50 (14%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 12/100 (12%)     Mean 12%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)     4/50 (8%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     4/50 (8%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     3/50 (6%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 7.07%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)   19/50 (38%)                       11/50 (22%)    9/50 (18%)                  |
| Overall Incidence               Total 36/100 (36%)    Mean 36%     SD 2.83%     Total 20/100 (20%)     Mean 20%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    9/50 (18%)                        7/50 (14%)    2/50 (4%)                   |
| Overall Incidence               Total 23/100 (23%)    Mean 23%     SD 7.07%     Total 9/100 (9%)       Mean 9%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   12/50 (24%)                        7/50 (14%)    2/50 (4%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 26/100 (26%)    Mean 26%     SD 2.83%     Total 9/100 (9%)       Mean 9%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         29/50 (58%)   24/50 (48%)                       17/50 (34%)   10/50 (20%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 53/100 (53%)    Mean 53%     SD 7.07%     Total 27/100 (27%)     Mean 27%     SD 9.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           29/50 (58%)   26/50 (52%)                       17/50 (34%)   10/50 (20%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 55/100 (55%)    Mean 55%     SD 4.24%     Total 27/100 (27%)     Mean 27%     SD 9.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/50 (6%)    10/50 (20%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 13/100 (13%)    Mean 13%     SD 9.9%      Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     4/50 (8%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    6/50 (12%)   13/50 (26%)                        3/50 (6%)     1/50 (2%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 19/100 (19%)    Mean 19%     SD 9.9%      Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 1/97 (1.03%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/47 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/97 (1.03%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)                         1/49 (2%)     1/48 (2%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 2/97 (2.06%)     Mean 2.06%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)                         1/49 (2%)     1/48 (2%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 2/97 (2.06%)     Mean 2.06%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     3/50 (6%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              3/50 (6%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/37 (0%)                         1/49 (2%)     0/46 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/37 (0%)                         0/49 (0%)     1/46 (2%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/37 (0%)                         0/49 (0%)     1/46 (2%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)                                     38/50 (76%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)                                     33/50 (66%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)                                     47/50 (94%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)                                      23/50 (46%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       3/50 (6%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)                                     11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)                                     12/50 (24%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/48 (2%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/48 (2%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   1/48 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/48 (0%)                                       2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/48 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       6/48 (13%)                                      1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/48 (63%)                                     30/49 (61%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            20/48 (42%)                                      3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         23/48 (48%)                                      4/49 (8%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         41/48 (85%)                                     31/49 (63%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           41/48 (85%)                                     31/49 (63%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   10/50 (20%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/45 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/45 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/45 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              3/45 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       3/46 (7%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)                                       3/46 (7%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       0/50 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       3/50 (6%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       3/50 (6%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/48 (0%)                                       2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/43 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
