                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)   29/50 (58%)   30/50 (60%)         28/49 (57%)   25/50 (50%)   25/50 (50%)    |
|                                       32/50 (64%)   31/50 (62%)                       27/50 (54%)   19/50 (38%)                  |
| Overall Incidence               Total 154/250 (61.6%) Mean 61.6%   SD 2.61%     Total 124/249 (49.8%)  Mean 49.83%  SD 7.26%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   21/50 (42%)   22/50 (44%)         22/49 (45%)   20/50 (40%)   23/50 (46%)    |
|                                       23/50 (46%)   27/50 (54%)                       19/50 (38%)   17/50 (34%)                  |
| Overall Incidence               Total 116/250 (46.4%) Mean 46.4%   SD 4.56%     Total 101/249 (40.56%) Mean 40.58%  SD 4.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   41/50 (82%)   41/50 (82%)         39/49 (80%)   35/50 (70%)   37/50 (74%)    |
|                                       42/50 (84%)   42/50 (84%)                       39/50 (78%)   32/50 (64%)                  |
| Overall Incidence               Total 209/250 (83.6%) Mean 83.6%   SD 1.67%     Total 182/249 (73.09%) Mean 73.12%  SD 6.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/250 (0.8%)    Mean 0.8%    SD 1.1%      Total 3/249 (1.2%)     Mean 1.21%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     3/50 (6%)     3/50 (6%)           1/49 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 9/250 (3.6%)    Mean 3.6%    SD 2.19%     Total 8/249 (3.21%)    Mean 3.21%   SD 1.78%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     3/50 (6%)     4/50 (8%)           2/49 (4%)     4/50 (8%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)                         2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 11/250 (4.4%)   Mean 4.4%    SD 2.61%     Total 11/249 (4.42%)   Mean 4.42%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 7/249 (2.81%)    Mean 2.8%    SD 2.28%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)     3/50 (6%)          11/49 (22%)    8/50 (16%)   13/50 (26%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     2/50 (4%)                         5/50 (10%)    7/50 (14%)                  |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 12/250 (4.8%)   Mean 4.8%    SD 1.79%     Total 44/249 (17.67%)  Mean 17.69%  SD 6.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     2/50 (4%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        4/49 (8%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 10/246 (4.07%)  Mean 4.07%   SD 2.5%      Total 2/248 (0.81%)    Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 1/248 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         1/49 (2%)     2/49 (4%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 7/242 (2.89%)    Mean 2.87%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     0/47 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         1/49 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 1/242 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|      Complex, Malignant, NOS           0/48 (0%)     0/50 (0%)                         2/49 (4%)     2/49 (4%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 8/242 (3.31%)    Mean 3.28%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/49 (2%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 2/247 (0.81%)    Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/42 (0%)     0/43 (0%)     0/38 (0%)           0/41 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/39 (0%)     0/42 (0%)                         0/40 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/204 (0%)      Mean 0%      SD 0%        Total 0/213 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/42 (0%)     0/43 (0%)     0/38 (0%)           0/41 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/39 (0%)     0/42 (0%)                         0/40 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/204 (0%)      Mean 0%      SD 0%        Total 0/213 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    1/50 (2%)     6/50 (12%)          3/49 (6%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)                        4/50 (8%)     2/50 (4%)                   |
| Overall Incidence               Total 28/250 (11.2%)  Mean 11.2%   SD 5.4%      Total 15/249 (6.02%)   Mean 6.02%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            3/50 (6%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 2.61%     Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    1/50 (2%)     7/50 (14%)          4/49 (8%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)                        5/50 (10%)    2/50 (4%)                   |
| Overall Incidence               Total 32/250 (12.8%)  Mean 12.8%   SD 6.26%     Total 17/249 (6.83%)   Mean 6.83%   SD 2.3%      |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/250 (0.8%)    Mean 0.8%    SD 1.79%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/250 (1.2%)    Mean 1.2%    SD 1.79%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 1.67%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/245 (2.86%)   Mean 2.84%   SD 2.3%      Total 3/247 (1.21%)    Mean 1.22%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/245 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/245 (2.86%)   Mean 2.84%   SD 2.3%      Total 3/247 (1.21%)    Mean 1.22%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/249 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/249 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/249 (0.8%)    Mean 0.8%    SD 1.79%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/250 (2.4%)    Mean 2.4%    SD 1.67%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)   17/50 (34%)   18/50 (36%)          7/49 (14%)   12/50 (24%)   14/49 (29%)    |
|                                       23/50 (46%)   15/50 (30%)                        9/50 (18%)    6/50 (12%)                  |
| Overall Incidence               Total 95/250 (38%)    Mean 38%     SD 6.78%     Total 48/248 (19.35%)  Mean 19.37%  SD 6.86%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|                                       16/50 (32%)   14/50 (28%)                        6/50 (12%)    6/50 (12%)                  |
| Overall Incidence               Total 60/250 (24%)    Mean 24%     SD 5.83%     Total 26/248 (10.48%)  Mean 10.47%  SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|      Hepatoblastoma                   16/50 (32%)   14/50 (28%)                        6/50 (12%)    6/50 (12%)                  |
| Overall Incidence               Total 60/250 (24%)    Mean 24%     SD 5.83%     Total 26/248 (10.48%)  Mean 10.47%  SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|      Hepatocellular Adenoma           34/50 (68%)   26/50 (52%)                       13/50 (26%)   12/50 (24%)                  |
| Overall Incidence               Total 139/250 (55.6%) Mean 55.6%   SD 7.27%     Total 72/248 (29.03%)  Mean 29.04%  SD 6.81%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|      Hepatocellular Adenoma, or       34/50 (68%)   26/50 (52%)                       13/50 (26%)   12/50 (24%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 139/250 (55.6%) Mean 55.6%   SD 7.27%     Total 72/248 (29.03%)  Mean 29.04%  SD 6.81%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   13/50 (26%)   13/50 (26%)          1/49 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        6/50 (12%)   13/50 (26%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 53/250 (21.2%)  Mean 21.2%   SD 6.72%     Total 9/249 (3.61%)    Mean 3.61%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    6/50 (12%)    6/50 (12%)          6/49 (12%)    1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)   12/50 (24%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 39/250 (15.6%)  Mean 15.6%   SD 4.98%     Total 8/249 (3.21%)    Mean 3.25%   SD 5.13%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   18/50 (36%)   17/50 (34%)          7/49 (14%)    4/50 (8%)     3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma     13/50 (26%)   22/50 (44%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 85/250 (34%)    Mean 34%     SD 6.78%     Total 17/249 (6.83%)   Mean 6.86%   SD 4.72%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 1/248 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        1/49 (2%)     1/48 (2%)                   |
| Overall Incidence                                                               Total 5/243 (2.06%)    Mean 2.03%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 2/243 (0.82%)    Mean 0.82%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 3/243 (1.23%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|   Adenoma                              0/49 (0%)     1/50 (2%)                        10/47 (21%)    8/49 (16%)                  |
| Overall Incidence               Total 2/238 (0.84%)   Mean 0.82%   SD 1.12%     Total 50/243 (20.58%)  Mean 20.58%  SD 3.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/49 (0%)     1/50 (2%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/238 (0.42%)   Mean 0.4%    SD 0.89%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|   Carcinoma or Adenoma                 0/49 (0%)     2/50 (4%)                        10/47 (21%)    8/49 (16%)                  |
| Overall Incidence               Total 3/238 (1.26%)   Mean 1.22%   SD 1.8%      Total 50/243 (20.58%)  Mean 20.58%  SD 3.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/243 (0.41%)   Mean 0.41%   SD 0.91%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/243 (0.41%)   Mean 0.41%   SD 0.91%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/243 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     2/50 (4%)     2/48 (4%)           1/49 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         1/49 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 4/246 (1.63%)   Mean 1.63%   SD 2.24%     Total 5/247 (2.02%)    Mean 2.02%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     2/50 (4%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 2.19%     Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 3/250 (1.2%)    Mean 1.2%    SD 1.79%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     2/50 (4%)     2/50 (4%)                                                     |
|                                        1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 5/250 (2%)      Mean 2%      SD 2%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/240 (0.83%)   Mean 0.82%   SD 1.13%     Total 3/248 (1.21%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)     1/47 (2%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/240 (0.42%)   Mean 0.43%   SD 0.95%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)     1/47 (2%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/240 (1.25%)   Mean 1.25%   SD 1.14%     Total 3/248 (1.21%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 4/249 (1.61%)    Mean 1.6%    SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        3/50 (6%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 6/249 (2.41%)    Mean 2.4%    SD 2.61%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   40/100(40%)   16/50 (32%)         15/50 (30%)   28/99 (28%)   15/50 (30%)    |
|                                       37/100(37%)   23/50 (46%)   30/60 (50%)         32/100(32%)   13/50 (26%)   21/60 (35%)    |
|                                       25/50 (50%)                                     17/50 (34%)                                |
| Overall Incidence               Total 198/460 (43.04%)Mean 44.14%  SD 8.01%     Total 141/459 (30.72%) Mean 30.75%  SD 3.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   32/100(32%)   21/50 (42%)         16/50 (32%)   24/99 (24%)   12/50 (24%)    |
|                                       28/100(28%)   20/50 (40%)   26/60 (43%)         46/100(46%)   12/50 (24%)   16/60 (27%)    |
|                                       14/50 (28%)                                      9/50 (18%)                                |
| Overall Incidence               Total 158/460 (34.35%)Mean 35.33%  SD 6.46%     Total 135/459 (29.41%) Mean 27.84%  SD 9.02%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)   55/100(55%)   32/50 (64%)         25/50 (50%)   45/99 (45%)   23/50 (46%)    |
|                                       57/100(57%)   32/50 (64%)   45/60 (75%)         62/100(62%)   23/50 (46%)   33/60 (55%)    |
|                                       31/50 (62%)                                     21/50 (42%)                                |
| Overall Incidence               Total 290/460 (63.04%)Mean 64.71%  SD 8.12%     Total 232/459 (50.54%) Mean 49.49%  SD 6.88%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        3/100(3%)     0/50 (0%)     1/60 (2%)           4/100(4%)     0/50 (0%)     3/60 (5%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 6/460 (1.3%)    Mean 0.95%   SD 1.25%     Total 9/459 (1.96%)    Mean 1.72%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/100(3%)     3/50 (6%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        2/100(2%)     2/50 (4%)     4/60 (7%)           1/100(1%)     2/50 (4%)     0/60 (0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 18/460 (3.91%)  Mean 4.24%   SD 1.99%     Total 5/459 (1.09%)    Mean 1.29%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)     5/100(5%)     3/50 (6%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        5/100(5%)     2/50 (4%)     5/60 (8%)           5/100(5%)     2/50 (4%)     3/60 (5%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 24/460 (5.22%)  Mean 5.19%   SD 1.95%     Total 14/459 (3.05%)   Mean 3%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     1/60 (2%)           2/100(2%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/460 (0.87%)   Mean 1.1%    SD 1.03%     Total 2/459 (0.44%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     4/100(4%)     3/50 (6%)           8/50 (16%)    7/99 (7%)     6/50 (12%)    |
|      Lymphocytic, Mixed, NOS, or       8/100(8%)     2/50 (4%)     3/60 (5%)          23/100(23%)    6/50 (12%)    8/60 (13%)    |
|      Undifferentiated Cell Type        3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 25/460 (5.43%)  Mean 5.29%   SD 1.5%      Total 61/459 (13.29%)  Mean 12.77%  SD 5.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      NOS                               0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 4/459 (0.87%)    Mean 1%      SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 4/459 (0.87%)    Mean 1%      SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/49 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        2/99 (2%)     0/50 (0%)     2/60 (3%)           0/100(0%)     0/50 (0%)     1/59 (2%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/457 (1.97%)   Mean 1.93%   SD 2.26%     Total 2/458 (0.44%)    Mean 0.53%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/99 (0%)     0/49 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 1/457 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/99 (0%)     0/49 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/99 (0%)     0/50 (0%)     0/60 (0%)           1/99 (1%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 3/457 (0.66%)    Mean 0.57%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/99 (0%)     0/49 (0%)           1/50 (2%)     1/99 (1%)     1/50 (2%)     |
|      Complex, Malignant, NOS           0/99 (0%)     0/50 (0%)     0/60 (0%)           1/99 (1%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 4/457 (0.88%)    Mean 0.86%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.29%   SD 0.76%     Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.67%   SD 0.88%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 3/459 (0.65%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 3/459 (0.65%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/459 (0.44%)    Mean 0.29%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/459 (0.44%)    Mean 0.29%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.24%   SD 0.63%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/46 (0%)     0/54 (0%)           0/100(0%)     0/49 (0%)     0/54 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/443 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/45 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/46 (0%)     0/54 (0%)           0/100(0%)     0/49 (0%)     0/54 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/443 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    4/100(4%)     5/50 (10%)          1/50 (2%)     3/99 (3%)     3/50 (6%)     |
|                                        8/100(8%)     9/50 (18%)    4/60 (7%)           2/100(2%)     3/50 (6%)     4/60 (7%)     |
|                                        3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 39/460 (8.48%)  Mean 9.24%   SD 4.67%     Total 18/459 (3.92%)   Mean 4.24%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     1/60 (2%)           1/100(1%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.81%   SD 1.02%     Total 4/459 (0.87%)    Mean 0.81%   SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 7/50 (14%)    4/100(4%)     5/50 (10%)          1/50 (2%)     4/99 (4%)     3/50 (6%)     |
|                                        8/100(8%)    10/50 (20%)    5/60 (8%)           3/100(3%)     4/50 (8%)     5/60 (8%)     |
|                                        3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 42/460 (9.13%)  Mean 10.05%  SD 5.4%      Total 22/459 (4.79%)   Mean 5.05%   SD 2.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.24%   SD 0.63%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.71%   SD 0.95%     Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     2/60 (3%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.33%   SD 1.45%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     2/60 (3%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.33%   SD 1.45%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     2/60 (3%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.33%   SD 1.45%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.24%   SD 0.63%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.71%   SD 0.95%     Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/458 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.14%   SD 0.38%     Total 1/458 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/58 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/58 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/458 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/58 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/458 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/58 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/100(2%)     2/50 (4%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     1/60 (2%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.67%   SD 1.37%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.24%   SD 0.63%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              11/50 (22%)   20/100(20%)    6/50 (12%)          5/50 (10%)    8/99 (8%)     4/50 (8%)     |
|                                       14/100(14%)    7/50 (14%)   18/60 (30%)          7/99 (7%)     3/50 (6%)     7/60 (12%)    |
|                                       14/50 (28%)                                      6/49 (12%)                                |
| Overall Incidence               Total 90/460 (19.57%) Mean 20%     SD 7.12%     Total 40/457 (8.75%)   Mean 9.01%   SD 2.35%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)   13/100(13%)    9/50 (18%)          0/50 (0%)     4/99 (4%)     3/50 (6%)     |
|                                       13/100(13%)    4/50 (8%)    12/60 (20%)          3/99 (3%)     2/50 (4%)     2/60 (3%)     |
|                                        8/50 (16%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 67/460 (14.57%) Mean 14.86%  SD 3.93%     Total 17/457 (3.72%)   Mean 3.79%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          8/50 (16%)   13/100(13%)    9/50 (18%)          0/50 (0%)     4/99 (4%)     3/50 (6%)     |
|      Hepatoblastoma                   13/100(13%)    4/50 (8%)    13/60 (22%)          3/99 (3%)     2/50 (4%)     2/60 (3%)     |
|                                        8/50 (16%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 68/460 (14.78%) Mean 15.1%   SD 4.33%     Total 17/457 (3.72%)   Mean 3.79%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         18/50 (36%)   28/100(28%)   15/50 (30%)          5/50 (10%)   12/99 (12%)    6/50 (12%)    |
|      Hepatocellular Adenoma           26/100(26%)   10/50 (20%)   27/60 (45%)          9/99 (9%)     4/50 (8%)     9/60 (15%)    |
|                                       20/50 (40%)                                      8/49 (16%)                                |
| Overall Incidence               Total 144/460 (31.3%) Mean 32.14%  SD 8.65%     Total 53/457 (11.6%)   Mean 11.79%  SD 3.05%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           18/50 (36%)   28/100(28%)   15/50 (30%)          5/50 (10%)   12/99 (12%)    6/50 (12%)    |
|      Hepatocellular Adenoma, or       26/100(26%)   10/50 (20%)   28/60 (47%)          9/99 (9%)     4/50 (8%)     9/60 (15%)    |
|      Hepatoblastoma                   20/50 (40%)                                      8/49 (16%)                                |
| Overall Incidence               Total 145/460 (31.52%)Mean 32.38%  SD 9.07%     Total 53/457 (11.6%)   Mean 11.79%  SD 3.05%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.57%   SD 1.51%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        14/50 (28%)   12/100(12%)    6/50 (12%)          0/50 (0%)     5/99 (5%)     0/50 (0%)     |
|                                        9/100(9%)    11/50 (22%)    9/60 (15%)          3/100(3%)     4/50 (8%)     2/60 (3%)     |
|                                        6/50 (12%)                                      5/50 (10%)                                |
| Overall Incidence               Total 67/460 (14.57%) Mean 15.71%  SD 6.8%      Total 19/459 (4.14%)   Mean 4.2%    SD 3.79%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     9/100(9%)     7/50 (14%)          1/50 (2%)     6/99 (6%)     0/50 (0%)     |
|                                        7/100(7%)     6/50 (12%)    5/60 (8%)           2/100(2%)     0/50 (0%)     3/60 (5%)     |
|                                        2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 38/460 (8.26%)  Mean 8.33%   SD 3.77%     Total 13/459 (2.83%)   Mean 2.44%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)   20/100(20%)   13/50 (26%)          1/50 (2%)    11/99 (11%)    0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma     14/100(14%)   14/50 (28%)   14/60 (23%)          5/100(5%)     4/50 (8%)     5/60 (8%)     |
|                                        8/50 (16%)                                      6/50 (12%)                                |
| Overall Incidence               Total 99/460 (21.52%) Mean 22.76%  SD 6.5%      Total 32/459 (6.97%)   Mean 6.63%   SD 4.5%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.24%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/459 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/459 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      or Adenoma                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/459 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)     0/50 (0%)     0/60 (0%)           0/99 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     3/99 (3%)     2/50 (4%)     |
|                                                                                        2/100(2%)     0/50 (0%)     1/59 (2%)     |
|                                                                                        3/48 (6%)                                 |
| Overall Incidence                                                               Total 12/455 (2.64%)   Mean 2.72%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     1/99 (1%)     1/50 (2%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence                                                               Total 4/455 (0.88%)    Mean 0.87%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     1/99 (1%)     1/50 (2%)     |
|      Malignant, NOS                                                                    1/100(1%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence                                                               Total 4/455 (0.88%)    Mean 0.87%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence                                                               Total 2/455 (0.44%)    Mean 0.44%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 1/455 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     1/99 (1%)     0/50 (0%)     |
|                                                                                        2/100(2%)     0/50 (0%)     2/59 (3%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 5/455 (1.1%)     Mean 0.91%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 0/455 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 1/455 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                1/49 (2%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 1/455 (0.22%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           2/50 (4%)     8/97 (8%)     3/48 (6%)     |
|   Adenoma                              0/98 (0%)     0/49 (0%)     1/53 (2%)          11/97 (11%)    1/50 (2%)     3/58 (5%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/441 (0.23%)   Mean 0.27%   SD 0.71%     Total 28/445 (6.29%)   Mean 5.29%   SD 3.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     0/97 (0%)     0/48 (0%)     |
|   Carcinoma                            0/98 (0%)     0/49 (0%)     0/53 (0%)           0/97 (0%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 0/441 (0%)      Mean 0%      SD 0%        Total 0/445 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           2/50 (4%)     8/97 (8%)     3/48 (6%)     |
|   Carcinoma or Adenoma                 0/98 (0%)     0/49 (0%)     1/53 (2%)          11/97 (11%)    1/50 (2%)     3/58 (5%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/441 (0.23%)   Mean 0.27%   SD 0.71%     Total 28/445 (6.29%)   Mean 5.29%   SD 3.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     2/97 (2%)     1/48 (2%)     |
|                                        1/98 (1%)     0/49 (0%)     0/53 (0%)           0/97 (0%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/441 (0.23%)   Mean 0.15%   SD 0.39%     Total 3/445 (0.67%)    Mean 0.59%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     2/97 (2%)     1/48 (2%)     |
|                                        1/98 (1%)     0/49 (0%)     0/53 (0%)           0/97 (0%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/441 (0.23%)   Mean 0.15%   SD 0.39%     Total 3/445 (0.67%)    Mean 0.59%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/98 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/98 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.24%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|      Trichoepithelioma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|      NOS)                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    1/100(1%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        2/100(2%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.43%   SD 0.79%     Total 2/459 (0.44%)    Mean 0.29%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/60 (0%)           0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 2/459 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma                         1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          1/100(1%)     0/50 (0%)     0/60 (0%)           1/100(1%)     0/50 (0%)     0/60 (0%)     |
|      Carcinoma or Keratoacanthoma      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     1/100(1%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/100(0%)     1/50 (2%)     0/60 (0%)           4/100(4%)     0/50 (0%)     1/60 (2%)     |
|      Histiocytoma                      0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 11/459 (2.4%)    Mean 2.24%   SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           4/100(4%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 6/459 (1.31%)    Mean 1.14%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           0/100(0%)     1/50 (2%)     0/60 (0%)           4/100(4%)     0/50 (0%)     1/60 (2%)     |
|      Histiocytoma                      0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.43%   SD 0.79%     Total 11/459 (2.4%)    Mean 2.24%   SD 1.4%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/100(0%)     0/50 (0%)     0/60 (0%)           2/100(2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 3/459 (0.65%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/100(0%)     0/50 (0%)     0/60 (0%)           2/100(2%)     0/50 (0%)     0/60 (0%)     |
|      or NOS)                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 3/459 (0.65%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/60 (0%)           0/100(0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 4/459 (0.87%)    Mean 0.81%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           2/100(2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 3/459 (0.65%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     1/60 (2%)           0/97 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.24%   SD 0.63%     Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        1/100(1%)     1/50 (2%)     2/60 (3%)           0/97 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 6/460 (1.3%)    Mean 1.48%   SD 1.21%     Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/97 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/97 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.24%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/100(0%)     0/50 (0%)           2/50 (4%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous                0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     2/50 (4%)     1/60 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.57%   SD 0.98%     Total 7/459 (1.53%)    Mean 1.67%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           1/100(1%)     2/50 (4%)     1/60 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.57%   SD 0.98%     Total 6/459 (1.31%)    Mean 1.38%   SD 1.38%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/100(1%)     1/50 (2%)                                                     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.57%   SD 0.79%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/100(1%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.14%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/100(0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)     0/47 (0%)     0/57 (0%)           0/93 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/428 (0%)      Mean 0%      SD 0%        Total 0/438 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)     0/47 (0%)     0/57 (0%)           0/93 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/428 (0%)      Mean 0%      SD 0%        Total 0/438 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)     0/47 (0%)     0/57 (0%)           0/93 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/428 (0%)      Mean 0%      SD 0%        Total 0/438 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/59 (0%)           0/98 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/59 (0%)           0/98 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/59 (0%)           0/98 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/97 (0%)     2/50 (4%)     |
|                                        1/99 (1%)     0/50 (0%)     1/59 (2%)           1/98 (1%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/458 (1.09%)   Mean 1.1%    SD 0.86%     Total 4/454 (0.88%)    Mean 1.01%   SD 1.53%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/59 (0%)           0/98 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/97 (0%)     2/50 (4%)     |
|                                        1/99 (1%)     0/50 (0%)     1/59 (2%)           1/98 (1%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/458 (1.09%)   Mean 1.1%    SD 0.86%     Total 4/454 (0.88%)    Mean 1.01%   SD 1.53%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     2/60 (3%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.48%   SD 1.26%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous                0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/59 (0%)           0/100(0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/459 (0.44%)    Mean 0.38%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/459 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/459 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        4/50 (8%)     2/99 (2%)     1/50 (2%)     |
|                                                                                        1/100(1%)     0/50 (0%)     2/60 (3%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence                                                               Total 13/459 (2.83%)   Mean 3.19%   SD 2.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/459 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     5/50 (10%)    2/99 (2%)     1/50 (2%)     |
|                                                                                        1/100(1%)     1/50 (2%)     2/60 (3%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence                                                               Total 15/459 (3.27%)   Mean 3.76%   SD 3.19%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/60 (0%)           0/100(0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
