                                                 Toxicology Data Management System                                     Page: 1
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   729       50( )      41  (702)     52.2     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|BATTELLE TOXICOLOGY059700602T 06/05/00   729       50( )      40  (709)     53.2     METHYL ISOBUTYL KETONE                     |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   729       50(1)      45  (717)     46.1     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302008  05/08/00   729       50(1)      39  (710)     52.6     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|SOUTHERN RESEARCH  059601804  12/15/98   9999       0(5)       0  (  0)     N/A      BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   729       49(1)      31  (685)     52.5     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   731       50( )      33  (681)     63.0     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|BATTELLE TOXICOLOGY059700602T 06/05/00   731       50( )      35  (695)     60.3     METHYL ISOBUTYL KETONE                     |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   734       50(5)      42  (706)     45.6     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302008  05/08/00   732       50(1)      33  (674)     65.7     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|SOUTHERN RESEARCH  059601804  12/15/98   729       50(5)      36  (699)     66.6     BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   734       50(5)      38  (708)     64.3     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   27/50 (54%)   40/100(40%)         29/50 (58%)   15/50 (30%)   28/99 (28%)    |
|                                       27/50 (54%)   29/50 (58%)   29/49 (59%)         22/50 (44%)   17/50 (34%)   24/50 (48%)    |
|                                       16/50 (32%)   28/50 (56%)   37/100(37%)         15/50 (30%)   13/50 (26%)   32/100(32%)    |
|                                       30/50 (60%)   32/50 (64%)   35/50 (70%)         24/50 (48%)   28/49 (57%)   28/50 (56%)    |
|                                       29/50 (58%)   30/50 (60%)   32/50 (64%)         25/50 (50%)   25/50 (50%)   27/50 (54%)    |
|                                       31/50 (62%)   27/50 (54%)   54/100(54%)         19/50 (38%)   29/50 (58%)   52/100(52%)    |
|                                       37/50 (74%)   23/50 (46%)   26/50 (52%)         27/50 (54%)   13/50 (26%)   18/50 (36%)    |
|                                       34/50 (68%)   29/50 (58%)   30/60 (50%)         38/50 (76%)   35/50 (70%)   21/60 (35%)    |
|                                       25/50 (50%)   32/50 (64%)     0/0 (0%)          17/50 (34%)   15/50 (30%)   34/50 (68%)    |
|                                       25/49 (51%)                                     29/50 (58%)                                |
| Overall Incidence               Total 828/1508 (54.91%Mean 54.19%  SD 14.34%    Total 699/1558 (44.87%)Mean 45.73%  SD 14.24%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   17/50 (34%)   32/100(32%)         24/50 (48%)   16/50 (32%)   24/99 (24%)    |
|                                       19/50 (38%)   24/50 (48%)   24/49 (49%)         18/50 (36%)   17/50 (34%)   20/50 (40%)    |
|                                       21/50 (42%)   27/50 (54%)   28/100(28%)         12/50 (24%)   12/50 (24%)   46/100(46%)    |
|                                       28/50 (56%)   23/50 (46%)   26/50 (52%)         27/50 (54%)   22/49 (45%)   22/50 (44%)    |
|                                       21/50 (42%)   22/50 (44%)   23/50 (46%)         20/50 (40%)   23/50 (46%)   19/50 (38%)    |
|                                       27/50 (54%)   29/50 (58%)   40/100(40%)         17/50 (34%)   30/50 (60%)   55/100(55%)    |
|                                       23/50 (46%)   20/50 (40%)   15/50 (30%)         17/50 (34%)   12/50 (24%)   20/50 (40%)    |
|                                       29/50 (58%)   27/50 (54%)   26/60 (43%)         33/50 (66%)   26/50 (52%)   16/60 (27%)    |
|                                       14/50 (28%)   29/50 (58%)     0/0 (0%)           9/50 (18%)   21/50 (42%)   43/50 (86%)    |
|                                       23/49 (47%)                                     36/50 (72%)                                |
| Overall Incidence               Total 666/1508 (44.16%Mean 43.76%  SD 12.64%    Total 657/1558 (42.17%)Mean 42.31%  SD 15.73%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   38/50 (76%)   55/100(55%)         39/50 (78%)   25/50 (50%)   45/99 (45%)    |
|                                       39/50 (78%)   38/50 (76%)   40/49 (82%)         32/50 (64%)   29/50 (58%)   34/50 (68%)    |
|                                       32/50 (64%)   40/50 (80%)   57/100(57%)         23/50 (46%)   21/50 (42%)   62/100(62%)    |
|                                       45/50 (90%)   43/50 (86%)   43/50 (86%)         38/50 (76%)   39/49 (80%)   40/50 (80%)    |
|                                       41/50 (82%)   41/50 (82%)   42/50 (84%)         35/50 (70%)   37/50 (74%)   39/50 (78%)    |
|                                       42/50 (84%)   45/50 (90%)   71/100(71%)         32/50 (64%)   42/50 (84%)   78/100(78%)    |
|                                       45/50 (90%)   32/50 (64%)   34/50 (68%)         39/50 (78%)   23/50 (46%)   29/50 (58%)    |
|                                       45/50 (90%)   42/50 (84%)   45/60 (75%)         47/50 (94%)   47/50 (94%)   33/60 (55%)    |
|                                       31/50 (62%)   44/50 (88%)     0/0 (0%)          21/50 (42%)   31/50 (62%)   46/50 (92%)    |
|                                       37/49 (76%)                                     42/50 (84%)                                |
| Overall Incidence               Total 1152/1508 (76.39Mean 75.33%  SD 18.03%    Total 1048/1558 (67.27%Mean 67.93%  SD 15.93%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/60 (2%)           2/50 (4%)     2/50 (4%)     3/60 (5%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 16/1508 (1.06%) Mean 0.95%   SD 1.31%     Total 26/1558 (1.67%)  Mean 1.64%   SD 1.87%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/50 (6%)     3/100(3%)           4/50 (8%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     6/50 (12%)    3/49 (6%)           3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     7/50 (14%)    2/100(2%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        3/50 (6%)     1/50 (2%)     6/50 (12%)          3/50 (6%)     1/49 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     6/100(6%)           2/50 (4%)     3/50 (6%)     2/100(2%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     0/50 (0%)     4/60 (7%)           3/50 (6%)     4/50 (8%)     0/60 (0%)     |
|                                        1/50 (2%)     3/50 (6%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     8/50 (16%)    |
|                                        4/49 (8%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 77/1508 (5.11%) Mean 5.07%   SD 3.62%     Total 53/1558 (3.4%)   Mean 3.68%   SD 3.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    3/50 (6%)     5/100(5%)           4/50 (8%)     1/50 (2%)     1/99 (1%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           5/50 (10%)    1/50 (2%)     4/50 (8%)     |
|                                        3/50 (6%)     7/50 (14%)    5/100(5%)           0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                        4/50 (8%)     1/50 (2%)     6/50 (12%)          4/50 (8%)     2/49 (4%)     2/50 (4%)     |
|                                        3/50 (6%)     4/50 (8%)     2/50 (4%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     4/50 (8%)     6/100(6%)           2/50 (4%)     3/50 (6%)     2/100(2%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     1/50 (2%)     5/60 (8%)           5/50 (10%)    6/50 (12%)    3/60 (5%)     |
|                                        1/50 (2%)     3/50 (6%)      0/0 (0%)           2/50 (4%)     0/50 (0%)     8/50 (16%)    |
|                                        4/49 (8%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 93/1508 (6.17%) Mean 6.02%   SD 3.53%     Total 78/1558 (5.01%)  Mean 5.25%   SD 3.81%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           4/50 (8%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     1/100(1%)           3/50 (6%)     3/50 (6%)     2/100(2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/60 (2%)           0/50 (0%)     3/50 (6%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 10/1508 (0.66%) Mean 0.67%   SD 0.93%     Total 26/1558 (1.67%)  Mean 1.71%   SD 2.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     4/100(4%)           4/50 (8%)     8/50 (16%)    7/99 (7%)     |
|      Lymphocytic, Mixed, NOS, or       1/50 (2%)     3/50 (6%)     2/49 (4%)           5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|      Undifferentiated Cell Type        3/50 (6%)     1/50 (2%)     8/100(8%)           6/50 (12%)    7/50 (14%)   23/100(23%)    |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           8/50 (16%)   11/49 (22%)   11/50 (22%)    |
|                                        1/50 (2%)     3/50 (6%)     3/50 (6%)           8/50 (16%)   13/50 (26%)    5/50 (10%)    |
|                                        2/50 (4%)     1/50 (2%)     8/100(8%)           7/50 (14%)   13/50 (26%)   32/100(32%)    |
|                                        2/50 (4%)     2/50 (4%)     3/50 (6%)           4/50 (8%)     6/50 (12%)    7/50 (14%)    |
|                                        3/50 (6%)     2/50 (4%)     3/60 (5%)          23/50 (46%)   10/50 (20%)    8/60 (13%)    |
|                                        3/50 (6%)     3/50 (6%)      0/0 (0%)           3/50 (6%)     7/50 (14%)   29/50 (58%)    |
|                                        0/49 (0%)                                      27/50 (54%)                                |
| Overall Incidence               Total 70/1508 (4.64%) Mean 4.25%   SD 2.27%     Total 308/1558 (19.77%)Mean 19.71%  SD 13.28%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      NOS                               1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 8/1558 (0.51%)   Mean 0.5%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 10/1558 (0.64%)  Mean 0.64%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     5/49 (10%)          0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        3/50 (6%)     2/49 (4%)     3/49 (6%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/48 (2%)     4/49 (8%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     3/99 (3%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        4/50 (8%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/50 (10%)    2/60 (3%)           1/50 (2%)     0/50 (0%)     1/59 (2%)     |
|                                        3/49 (6%)     3/49 (6%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 62/1498 (4.14%) Mean 4.19%   SD 3.14%     Total 5/1546 (0.32%)   Mean 0.35%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1498 (0%)     Mean 0%      SD 0%        Total 1/1546 (0.06%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/92 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1498 (0%)     Mean 0%      SD 0%        Total 2/1546 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     2/49 (4%)           1/49 (2%)     2/48 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/48 (0%)           2/49 (4%)     0/47 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/98 (1%)           2/49 (4%)     2/50 (4%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 4/1491 (0.27%)  Mean 0.25%   SD 0.86%     Total 15/1533 (0.98%)  Mean 1.09%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/47 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     2/98 (2%)           0/49 (0%)     0/50 (0%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           2/50 (4%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1491 (0.34%)  Mean 0.29%   SD 0.72%     Total 7/1533 (0.46%)   Mean 0.43%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/99 (1%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/49 (0%)     2/49 (4%)           1/49 (2%)     2/48 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/48 (0%)           2/49 (4%)     0/47 (0%)     2/49 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     2/98 (2%)           2/49 (4%)     2/50 (4%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           3/50 (6%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 8/1491 (0.54%)  Mean 0.51%   SD 1.05%     Total 22/1533 (1.44%)  Mean 1.52%   SD 1.78%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/49 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     2/50 (4%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/49 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 13/1498 (0.87%) Mean 0.93%   SD 1.49%     Total 7/1550 (0.45%)   Mean 0.5%    SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1498 (0.07%)  Mean 0.04%   SD 0.19%     Total 0/1550 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     1/60 (2%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1498 (0.27%)  Mean 0.24%   SD 0.61%     Total 1/1550 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 6/1558 (0.39%)   Mean 0.36%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 8/1558 (0.51%)   Mean 0.5%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1555 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1555 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 3/1558 (0.19%)   Mean 0.14%   SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 3/1558 (0.19%)   Mean 0.14%   SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.06%   SD 0.31%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/1506 (0.07%)  Mean 0.04%   SD 0.19%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/1506 (0.07%)  Mean 0.07%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)     0/42 (0%)     1/42 (2%)           0/48 (0%)     0/41 (0%)     0/45 (0%)     |
|                                        0/43 (0%)     0/38 (0%)     0/39 (0%)           0/46 (0%)     0/40 (0%)     0/40 (0%)     |
|                                        0/42 (0%)     0/43 (0%)     0/84 (0%)           0/46 (0%)     0/42 (0%)     0/70 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/54 (0%)           0/40 (0%)     0/42 (0%)     0/54 (0%)     |
|                                        0/49 (0%)     0/44 (0%)      0/0 (0%)           0/49 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/39 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 1/1362 (0.07%)  Mean 0.09%   SD 0.45%     Total 0/1415 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)     0/42 (0%)     0/42 (0%)           0/48 (0%)     0/41 (0%)     0/45 (0%)     |
|                                        0/43 (0%)     0/38 (0%)     0/39 (0%)           0/46 (0%)     0/40 (0%)     0/40 (0%)     |
|                                        0/42 (0%)     0/43 (0%)     0/84 (0%)           0/46 (0%)     0/42 (0%)     0/70 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/54 (0%)           0/40 (0%)     0/42 (0%)     0/54 (0%)     |
|                                        0/49 (0%)     0/44 (0%)      0/0 (0%)           0/49 (0%)     1/45 (2%)     0/46 (0%)     |
|                                        0/39 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/1362 (0%)     Mean 0%      SD 0%        Total 1/1415 (0.07%)   Mean 0.08%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    6/50 (12%)    4/100(4%)          10/50 (20%)    1/50 (2%)     3/99 (3%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     2/50 (4%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)    6/50 (12%)    5/50 (10%)          5/50 (10%)    3/49 (6%)     4/50 (8%)     |
|                                        1/50 (2%)     6/50 (12%)    7/50 (14%)          3/50 (6%)     3/50 (6%)     4/50 (8%)     |
|                                        8/50 (16%)    5/50 (10%)   12/100(12%)          2/50 (4%)     6/50 (12%)   10/100(10%)    |
|                                        7/50 (14%)    9/50 (18%)    4/50 (8%)           7/50 (14%)    3/50 (6%)     6/50 (12%)    |
|                                        6/50 (12%)    9/50 (18%)    4/60 (7%)          11/50 (22%)    9/50 (18%)    4/60 (7%)     |
|                                        3/50 (6%)     4/50 (8%)      0/0 (0%)           2/50 (4%)     2/50 (4%)     3/50 (6%)     |
|                                        3/49 (6%)                                       9/50 (18%)                                |
| Overall Incidence               Total 149/1508 (9.88%)Mean 9.75%   SD 4.49%     Total 122/1558 (7.83%) Mean 8.14%   SD 5.78%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           2/50 (4%)     1/49 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     1/50 (2%)     2/100(2%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     1/60 (2%)           1/50 (2%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     2/50 (4%)      0/0 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 19/1508 (1.26%) Mean 1.35%   SD 1.72%     Total 23/1558 (1.48%)  Mean 1.49%   SD 1.37%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    7/50 (14%)    4/100(4%)          11/50 (22%)    1/50 (2%)     4/99 (4%)     |
|                                        3/50 (6%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     4/50 (8%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     3/100(3%)     |
|                                        7/50 (14%)    9/50 (18%)    6/50 (12%)          7/50 (14%)    4/49 (8%)     6/50 (12%)    |
|                                        1/50 (2%)     7/50 (14%)    7/50 (14%)          3/50 (6%)     3/50 (6%)     5/50 (10%)    |
|                                        8/50 (16%)    7/50 (14%)   12/100(12%)          2/50 (4%)     7/50 (14%)   12/100(12%)    |
|                                        9/50 (18%)   10/50 (20%)    5/50 (10%)          7/50 (14%)    4/50 (8%)     7/50 (14%)    |
|                                        6/50 (12%)   10/50 (20%)    5/60 (8%)          12/50 (24%)   10/50 (20%)    5/60 (8%)     |
|                                        3/50 (6%)     6/50 (12%)     0/0 (0%)           2/50 (4%)     4/50 (8%)     4/50 (8%)     |
|                                        3/49 (6%)                                      10/50 (20%)                                |
| Overall Incidence               Total 167/1508 (11.07%Mean 11.02%  SD 5.13%     Total 145/1558 (9.31%) Mean 9.63%   SD 6.29%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1507 (0.27%)  Mean 0.29%   SD 0.9%      Total 1/1553 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.39%     Total 0/1553 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1553 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 4/1558 (0.26%)   Mean 0.29%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1508 (0.33%)  Mean 0.36%   SD 0.96%     Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.06%   SD 0.31%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/1508 (0.53%)  Mean 0.46%   SD 1%        Total 5/1558 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 32/1508 (2.12%) Mean 2.08%   SD 2.73%     Total 3/1558 (0.19%)   Mean 0.18%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.22%   SD 0.63%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/1508 (0.4%)   Mean 0.43%   SD 1.01%     Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 33/1508 (2.19%) Mean 2.16%   SD 2.69%     Total 5/1558 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     3/49 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/100(1%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 39/1508 (2.59%) Mean 2.59%   SD 2.75%     Total 8/1558 (0.51%)   Mean 0.54%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.06%   SD 0.31%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 11/1508 (0.73%) Mean 0.68%   SD 1.22%     Total 5/1558 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     1/49 (2%)           0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                        3/50 (6%)     2/48 (4%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        1/50 (2%)     1/49 (2%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     2/87 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           1/47 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     3/49 (6%)     |
|                                        0/46 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 25/1491 (1.68%) Mean 1.74%   SD 2.09%     Total 12/1525 (0.79%)  Mean 0.81%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1491 (0.13%)  Mean 0.07%   SD 0.38%     Total 2/1525 (0.13%)   Mean 0.15%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     1/49 (2%)           0/50 (0%)     1/49 (2%)     1/48 (2%)     |
|                                        3/50 (6%)     2/48 (4%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        1/50 (2%)     1/49 (2%)     3/99 (3%)           0/50 (0%)     0/50 (0%)     2/87 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           1/47 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     3/49 (6%)     |
|                                        0/46 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 27/1491 (1.81%) Mean 1.81%   SD 2.1%      Total 14/1525 (0.92%)  Mean 0.96%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 8/1500 (0.53%)  Mean 0.54%   SD 0.89%     Total 0/1540 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 4/1500 (0.27%)  Mean 0.25%   SD 0.65%     Total 0/1540 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 12/1500 (0.8%)  Mean 0.79%   SD 1.14%     Total 0/1540 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1500 (0%)     Mean 0%      SD 0%        Total 1/1540 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/50 (2%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1506 (0.13%)  Mean 0.15%   SD 0.54%     Total 0/1549 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           2/49 (4%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 3/1506 (0.2%)   Mean 0.21%   SD 0.63%     Total 5/1549 (0.32%)   Mean 0.36%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)     2/100(2%)           2/50 (4%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/49 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     4/100(4%)           0/50 (0%)     1/50 (2%)     1/98 (1%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     1/60 (2%)           1/49 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        1/50 (2%)     2/50 (4%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        1/49 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 35/1506 (2.32%) Mean 2.28%   SD 1.7%      Total 12/1549 (0.77%)  Mean 0.83%   SD 1.37%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/98 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        6/48 (13%)    0/50 (0%)     1/60 (2%)           1/49 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/50 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 22/1506 (1.46%) Mean 1.51%   SD 3.12%     Total 4/1549 (0.26%)   Mean 0.29%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   11/50 (22%)   20/100(20%)         14/50 (28%)    5/50 (10%)    8/99 (8%)     |
|                                       17/50 (34%)   19/50 (38%)   17/49 (35%)         11/50 (22%)    7/50 (14%)    9/50 (18%)    |
|                                        6/50 (12%)   19/50 (38%)   14/100(14%)          4/50 (8%)     9/50 (18%)    7/99 (7%)     |
|                                       19/50 (38%)   22/50 (44%)   22/50 (44%)          9/50 (18%)    7/49 (14%)   17/49 (35%)    |
|                                       17/50 (34%)   18/50 (36%)   23/50 (46%)         12/50 (24%)   14/49 (29%)    9/50 (18%)    |
|                                       15/50 (30%)   17/50 (34%)   30/100(30%)          6/50 (12%)   13/50 (26%)   17/98 (17%)    |
|                                       23/50 (46%)    7/50 (14%)   17/50 (34%)         11/50 (22%)    3/50 (6%)     4/50 (8%)     |
|                                       30/48 (63%)   18/50 (36%)   18/60 (30%)         30/49 (61%)   21/50 (42%)    7/60 (12%)    |
|                                       14/50 (28%)   16/50 (32%)     0/0 (0%)           6/49 (12%)    9/49 (18%)   24/50 (48%)    |
|                                       18/49 (37%)                                     19/49 (39%)                                |
| Overall Incidence               Total 490/1506 (32.54%Mean 32.64%  SD 12.66%    Total 312/1549 (20.14%)Mean 21.23%  SD 13.43%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|                                       14/50 (28%)   11/50 (22%)   13/49 (27%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)    9/50 (18%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       17/50 (34%)   10/50 (20%)   13/50 (26%)          6/50 (12%)    4/49 (8%)     5/49 (10%)    |
|                                       11/50 (22%)    9/50 (18%)   16/50 (32%)          6/50 (12%)    4/49 (8%)     6/50 (12%)    |
|                                       14/50 (28%)   12/50 (24%)   19/100(19%)          6/50 (12%)    6/50 (12%)    6/98 (6%)     |
|                                        8/50 (16%)    4/50 (8%)    10/50 (20%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                       20/48 (42%)   20/50 (40%)   12/60 (20%)          3/49 (6%)    10/50 (20%)    2/60 (3%)     |
|                                        8/50 (16%)   23/50 (46%)     0/0 (0%)           3/49 (6%)     8/49 (16%)   13/50 (26%)    |
|                                       14/49 (29%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 344/1506 (22.84%Mean 22.92%  SD 10.03%    Total 128/1549 (8.26%) Mean 8.71%   SD 5.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|      Hepatoblastoma                   14/50 (28%)   12/50 (24%)   14/49 (29%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)   12/50 (24%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       18/50 (36%)   10/50 (20%)   13/50 (26%)          6/50 (12%)    4/49 (8%)     5/49 (10%)    |
|                                       11/50 (22%)    9/50 (18%)   16/50 (32%)          6/50 (12%)    4/49 (8%)     6/50 (12%)    |
|                                       14/50 (28%)   12/50 (24%)   21/100(21%)          6/50 (12%)    6/50 (12%)    6/98 (6%)     |
|                                       10/50 (20%)    4/50 (8%)    10/50 (20%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                       23/48 (48%)   20/50 (40%)   13/60 (22%)          4/49 (8%)    10/50 (20%)    2/60 (3%)     |
|                                        8/50 (16%)   24/50 (48%)     0/0 (0%)           3/49 (6%)     8/49 (16%)   14/50 (28%)    |
|                                       14/49 (29%)                                      4/49 (8%)                                 |
| Overall Incidence               Total 359/1506 (23.84%Mean 23.92%  SD 10.62%    Total 131/1549 (8.46%) Mean 8.92%   SD 6.01%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma           29/50 (58%)   23/50 (46%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|                                       15/50 (30%)   24/50 (48%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)   28/50 (56%)   30/50 (60%)         12/50 (24%)   11/49 (22%)   19/49 (39%)    |
|                                       26/50 (52%)   25/50 (50%)   34/50 (68%)         18/50 (36%)   18/49 (37%)   13/50 (26%)    |
|                                       26/50 (52%)   27/50 (54%)   46/100(46%)         12/50 (24%)   17/50 (34%)   22/98 (22%)    |
|                                       31/50 (62%)   10/50 (20%)   23/50 (46%)         13/50 (26%)    4/50 (8%)     5/50 (10%)    |
|                                       41/48 (85%)   35/50 (70%)   27/60 (45%)         31/49 (63%)   29/50 (58%)    9/60 (15%)    |
|                                       20/50 (40%)   36/50 (72%)     0/0 (0%)           8/49 (16%)   16/49 (33%)   30/50 (60%)    |
|                                       28/49 (57%)                                     22/49 (45%)                                |
| Overall Incidence               Total 745/1506 (49.47%Mean 49.52%  SD 17.81%    Total 408/1549 (26.34%)Mean 27.71%  SD 15.46%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma, or       29/50 (58%)   24/50 (48%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|      Hepatoblastoma                   15/50 (30%)   26/50 (52%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)   28/50 (56%)   30/50 (60%)         12/50 (24%)   11/49 (22%)   19/49 (39%)    |
|                                       26/50 (52%)   25/50 (50%)   34/50 (68%)         18/50 (36%)   18/49 (37%)   13/50 (26%)    |
|                                       26/50 (52%)   27/50 (54%)   47/100(47%)         12/50 (24%)   17/50 (34%)   22/98 (22%)    |
|                                       31/50 (62%)   10/50 (20%)   23/50 (46%)         13/50 (26%)    4/50 (8%)     5/50 (10%)    |
|                                       41/48 (85%)   35/50 (70%)   28/60 (47%)         31/49 (63%)   29/50 (58%)    9/60 (15%)    |
|                                       20/50 (40%)   36/50 (72%)     0/0 (0%)           8/49 (16%)   16/49 (33%)   31/50 (62%)    |
|                                       28/49 (57%)                                     22/49 (45%)                                |
| Overall Incidence               Total 750/1506 (49.8%)Mean 49.83%  SD 17.78%    Total 409/1549 (26.4%) Mean 27.78%  SD 15.62%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    0/100(0%)           0/50 (0%)     1/50 (2%)     1/98 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 9/1506 (0.6%)   Mean 0.64%   SD 2.04%     Total 4/1549 (0.26%)   Mean 0.25%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/1506 (0%)     Mean 0%      SD 0%        Total 2/1549 (0.13%)   Mean 0.15%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.39%     Total 1/1552 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   14/50 (28%)   12/100(12%)          4/50 (8%)     0/50 (0%)     5/99 (5%)     |
|                                        3/50 (6%)    10/50 (20%)    2/49 (4%)           2/50 (4%)     2/50 (4%)     6/50 (12%)    |
|                                        6/50 (12%)   10/50 (20%)    9/100(9%)           0/50 (0%)     1/50 (2%)     3/100(3%)     |
|                                        6/50 (12%)    8/50 (16%)   12/49 (24%)          3/50 (6%)     1/49 (2%)     4/50 (8%)     |
|                                       13/50 (26%)   13/50 (26%)    6/50 (12%)          3/50 (6%)     2/50 (4%)     2/50 (4%)     |
|                                       13/50 (26%)    9/50 (18%)   26/100(26%)          1/50 (2%)     4/50 (8%)     9/95 (9%)     |
|                                       11/50 (22%)   11/50 (22%)    8/50 (16%)          2/49 (4%)     4/50 (8%)     0/50 (0%)     |
|                                        6/50 (12%)    6/50 (12%)    9/60 (15%)          3/50 (6%)     4/50 (8%)     2/60 (3%)     |
|                                        6/50 (12%)   12/50 (24%)     0/0 (0%)           5/50 (10%)    1/50 (2%)     6/50 (12%)    |
|                                        7/49 (14%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 258/1507 (17.12%Mean 16.67%  SD 7.34%     Total 80/1552 (5.15%)  Mean 5.11%   SD 3.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     2/50 (4%)     9/100(9%)           2/50 (4%)     1/50 (2%)     6/99 (6%)     |
|                                        3/50 (6%)     5/50 (10%)    4/49 (8%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)    4/50 (8%)     7/100(7%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)    8/50 (16%)    5/49 (10%)          2/50 (4%)     6/49 (12%)    2/50 (4%)     |
|                                        6/50 (12%)    6/50 (12%)    7/50 (14%)          1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                       12/50 (24%)    5/50 (10%)    8/100(8%)           0/50 (0%)     0/50 (0%)     2/95 (2%)     |
|                                        9/50 (18%)    6/50 (12%)    2/50 (4%)           0/49 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        4/50 (8%)     2/50 (4%)     5/60 (8%)           1/50 (2%)     0/50 (0%)     3/60 (5%)     |
|                                        2/50 (4%)     7/50 (14%)     0/0 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        5/49 (10%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 151/1507 (10.02%Mean 9.89%   SD 4.96%     Total 40/1552 (2.58%)  Mean 2.48%   SD 2.64%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   16/50 (32%)   20/100(20%)          6/50 (12%)    1/50 (2%)    11/99 (11%)    |
|      Alveolar/Bronchiolar Adenoma      6/50 (12%)   14/50 (28%)    6/49 (12%)          3/50 (6%)     3/50 (6%)     6/50 (12%)    |
|                                       13/50 (26%)   13/50 (26%)   14/100(14%)          0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                       12/50 (24%)   15/50 (30%)   16/49 (33%)          5/50 (10%)    7/49 (14%)    6/50 (12%)    |
|                                       18/50 (36%)   17/50 (34%)   13/50 (26%)          4/50 (8%)     3/50 (6%)     2/50 (4%)     |
|                                       22/50 (44%)   14/50 (28%)   30/100(30%)          1/50 (2%)     4/50 (8%)    11/95 (12%)    |
|                                       19/50 (38%)   14/50 (28%)    9/50 (18%)          2/49 (4%)     4/50 (8%)     3/50 (6%)     |
|                                       10/50 (20%)    8/50 (16%)   14/60 (23%)          4/50 (8%)     4/50 (8%)     5/60 (8%)     |
|                                        8/50 (16%)   18/50 (36%)     0/0 (0%)           6/50 (12%)    2/50 (4%)     6/50 (12%)    |
|                                       12/49 (24%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 385/1507 (25.55%Mean 25.1%   SD 9.41%     Total 117/1552 (7.54%) Mean 7.37%   SD 3.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1507 (0.13%)  Mean 0.11%   SD 0.42%     Total 1/1552 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 1/1552 (0.06%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.76%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.04%   SD 0.19%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.13%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 10/1558 (0.64%)  Mean 0.68%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 11/1558 (0.71%)  Mean 0.75%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 11/1558 (0.71%)  Mean 0.75%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 5/1558 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1500 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1500 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1500 (0%)     Mean 0%      SD 0%        Total 1/1555 (0.06%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.11%   SD 0.42%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 6/1558 (0.39%)   Mean 0.39%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.18%   SD 0.55%     Total 8/1558 (0.51%)   Mean 0.54%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.04%   SD 0.19%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    1/49 (2%)     3/99 (3%)     |
|                                                                                        0/50 (0%)     1/47 (2%)     2/50 (4%)     |
|                                                                                        2/50 (4%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)     1/49 (2%)     3/48 (6%)     |
|                                                                                        0/47 (0%)     2/50 (4%)     1/49 (2%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     3/79 (4%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     2/48 (4%)     |
|                                                                                        1/45 (2%)     1/49 (2%)     1/59 (2%)     |
|                                                                                        3/48 (6%)     1/49 (2%)     4/50 (8%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 45/1507 (2.99%)  Mean 3%      SD 3.25%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     2/79 (3%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     2/48 (4%)     |
|                                                                                        1/45 (2%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 13/1507 (0.86%)  Mean 0.82%   SD 1.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     2/79 (3%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     2/48 (4%)     |
|                                                                                        1/45 (2%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 13/1507 (0.86%)  Mean 0.82%   SD 1.16%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 6/1507 (0.4%)    Mean 0.4%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     1/79 (1%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 5/1507 (0.33%)   Mean 0.3%    SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)     1/49 (2%)     1/48 (2%)     |
|                                                                                        0/47 (0%)     2/50 (4%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     1/79 (1%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        3/45 (7%)     0/49 (0%)     2/59 (3%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 15/1507 (1%)     Mean 0.95%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 2/1507 (0.13%)   Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/1507 (0.07%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     1/49 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/1507 (0.07%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1491 (0.07%)  Mean 0.04%   SD 0.19%     Total 0/1526 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1491 (0%)     Mean 0%      SD 0%        Total 1/1526 (0.07%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Adenoma                              0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)     1/48 (2%)     0/48 (0%)           8/50 (16%)   13/49 (27%)    8/47 (17%)    |
|                                        0/48 (0%)     0/43 (0%)     0/49 (0%)          10/50 (20%)    9/48 (19%)   10/47 (21%)    |
|                                        1/50 (2%)     0/50 (0%)     0/83 (0%)           8/49 (16%)    7/50 (14%)   17/83 (20%)    |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     1/50 (2%)     5/49 (10%)    |
|                                        0/47 (0%)     0/48 (0%)     1/53 (2%)           3/46 (7%)     4/48 (8%)     3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)      0/0 (0%)           0/45 (0%)     5/48 (10%)    3/49 (6%)     |
|                                        0/45 (0%)                                       2/47 (4%)                                 |
| Overall Incidence               Total 4/1438 (0.28%)  Mean 0.29%   SD 0.71%     Total 150/1493 (10.05%)Mean 9.79%   SD 7.18%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/97 (0%)     |
|   Carcinoma                            0/49 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/43 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/83 (0%)           0/49 (0%)     0/50 (0%)     0/83 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/46 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     1/48 (2%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/45 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 1/1438 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1493 (0.07%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Carcinoma or Adenoma                 0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)     1/48 (2%)     0/48 (0%)           8/50 (16%)   13/49 (27%)    8/47 (17%)    |
|                                        0/48 (0%)     0/43 (0%)     0/49 (0%)          10/50 (20%)    9/48 (19%)   10/47 (21%)    |
|                                        2/50 (4%)     0/50 (0%)     0/83 (0%)           8/49 (16%)    7/50 (14%)   17/83 (20%)    |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     1/50 (2%)     5/49 (10%)    |
|                                        0/47 (0%)     0/48 (0%)     1/53 (2%)           3/46 (7%)     5/48 (10%)    3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)      0/0 (0%)           0/45 (0%)     5/48 (10%)    3/49 (6%)     |
|                                        0/45 (0%)                                       2/47 (4%)                                 |
| Overall Incidence               Total 5/1438 (0.35%)  Mean 0.36%   SD 0.95%     Total 151/1493 (10.11%)Mean 9.87%   SD 7.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     1/47 (2%)     |
|                                        0/48 (0%)     0/43 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/83 (0%)           0/49 (0%)     0/50 (0%)     1/83 (1%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     0/48 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/45 (0%)                                       1/47 (2%)                                 |
| Overall Incidence               Total 4/1438 (0.28%)  Mean 0.25%   SD 0.65%     Total 13/1493 (0.87%)  Mean 0.86%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     1/47 (2%)     |
|                                        0/48 (0%)     0/43 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/83 (0%)           0/49 (0%)     0/50 (0%)     1/83 (1%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     0/48 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/45 (0%)                                       1/47 (2%)                                 |
| Overall Incidence               Total 4/1438 (0.28%)  Mean 0.25%   SD 0.65%     Total 13/1493 (0.87%)  Mean 0.86%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)                                                     |
|                                        0/50 (0%)     1/49 (2%)     0/46 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 1/1494 (0.07%)  Mean 0.07%   SD 0.39%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)                                                     |
|                                        0/50 (0%)     1/49 (2%)     0/46 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 1/1494 (0.07%)  Mean 0.07%   SD 0.39%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/46 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 1/1494 (0.07%)  Mean 0.07%   SD 0.39%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/94 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 2/1538 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/94 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1507 (0%)     Mean 0%      SD 0%        Total 2/1538 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.06%   SD 0.31%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     3/100(3%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 5/1558 (0.32%)   Mean 0.21%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     3/100(3%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 5/1558 (0.32%)   Mean 0.21%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 12/1558 (0.77%)  Mean 0.82%   SD 2.13%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|      Keratoacanthoma,                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1508 (0.33%)  Mean 0.32%   SD 0.91%     Total 5/1558 (0.32%)   Mean 0.29%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1508 (0.27%)  Mean 0.18%   SD 0.55%     Total 5/1558 (0.32%)   Mean 0.29%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     4/50 (8%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1508 (0.27%)  Mean 0.29%   SD 0.71%     Total 18/1558 (1.16%)  Mean 1.29%   SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.53%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.53%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.52%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.07%   SD 0.26%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.18%   SD 0.55%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.18%   SD 0.55%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1508 (0.33%)  Mean 0.32%   SD 0.91%     Total 3/1558 (0.19%)   Mean 0.18%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1508 (0.33%)  Mean 0.32%   SD 0.91%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.14%   SD 0.53%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     2/49 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           2/50 (4%)     4/50 (8%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           2/50 (4%)     3/50 (6%)     5/50 (10%)    |
|                                        1/49 (2%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 9/1508 (0.6%)   Mean 0.61%   SD 1.32%     Total 54/1558 (3.47%)  Mean 3.49%   SD 2.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/100(1%)           2/50 (4%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.04%   SD 0.19%     Total 15/1558 (0.96%)  Mean 0.93%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     2/49 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           2/50 (4%)     4/50 (8%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           2/50 (4%)     3/50 (6%)     5/50 (10%)    |
|                                        0/49 (0%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 7/1508 (0.46%)  Mean 0.46%   SD 1.26%     Total 54/1558 (3.47%)  Mean 3.49%   SD 2.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     2/50 (4%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.21%   SD 0.83%     Total 5/1558 (0.32%)   Mean 0.36%   SD 1.34%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 11/1558 (0.71%)  Mean 0.64%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 11/1558 (0.71%)  Mean 0.64%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     2/99 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     2/49 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           2/50 (4%)     2/50 (4%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     3/50 (6%)     4/50 (8%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.21%   SD 0.63%     Total 34/1558 (2.18%)  Mean 2.21%   SD 2.27%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 11/1558 (0.71%)  Mean 0.64%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/91 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/60 (2%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1492 (0.13%)  Mean 0.13%   SD 0.49%     Total 1/1530 (0.07%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           1/50 (2%)     0/47 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     1/100(1%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        2/49 (4%)     0/49 (0%)     1/49 (2%)           1/50 (2%)     1/49 (2%)     0/49 (0%)     |
|                                        2/50 (4%)     2/48 (4%)     0/49 (0%)           1/50 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     2/99 (2%)           2/50 (4%)     1/50 (2%)     0/91 (0%)     |
|                                        2/49 (4%)     1/50 (2%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     2/49 (4%)     |
|                                        0/48 (0%)     0/49 (0%)     2/60 (3%)           2/49 (4%)     1/49 (2%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     4/50 (8%)     |
|                                        2/47 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 26/1492 (1.74%) Mean 1.75%   SD 1.76%     Total 18/1530 (1.18%)  Mean 1.3%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/91 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/60 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1492 (0.07%)  Mean 0.04%   SD 0.19%     Total 0/1530 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/91 (1%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/60 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1492 (0%)     Mean 0%      SD 0%        Total 1/1530 (0.07%)   Mean 0.04%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.06%   SD 0.31%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1508 (0.27%)  Mean 0.29%   SD 0.72%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     2/50 (4%)     1/99 (1%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/100(0%)           2/50 (4%)     1/50 (2%)     1/100(1%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 20/1508 (1.33%) Mean 1.43%   SD 1.62%     Total 26/1558 (1.67%)  Mean 1.74%   SD 1.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     1/50 (2%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/100(0%)           2/50 (4%)     1/50 (2%)     1/100(1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 16/1508 (1.06%) Mean 1.14%   SD 1.58%     Total 24/1558 (1.54%)  Mean 1.6%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        3/50 (6%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        2/50 (4%)     2/50 (4%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 14/1507 (0.93%) Mean 0.89%   SD 1.55%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 2/1507 (0.13%)  Mean 0.11%   SD 0.42%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        1/49 (2%)                                                                                 |
| Overall Incidence               Total 3/1507 (0.2%)   Mean 0.18%   SD 0.55%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/1507 (0.07%)  Mean 0.07%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           1/49 (2%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/44 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/35 (0%)     0/40 (0%)     0/41 (0%)           0/47 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/35 (0%)     0/42 (0%)     0/69 (0%)           0/44 (0%)     0/49 (0%)     0/78 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/1302 (0%)     Mean 0%      SD 0%        Total 1/1454 (0.07%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/44 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/35 (0%)     0/40 (0%)     0/41 (0%)           0/47 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/35 (0%)     0/42 (0%)     0/69 (0%)           0/44 (0%)     0/49 (0%)     1/78 (1%)     |
|                                        0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/1302 (0%)     Mean 0%      SD 0%        Total 2/1454 (0.14%)   Mean 0.12%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/44 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/35 (0%)     0/40 (0%)     0/41 (0%)           0/47 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/35 (0%)     1/42 (2%)     0/69 (0%)           0/44 (0%)     0/49 (0%)     0/78 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 1/1302 (0.08%)  Mean 0.09%   SD 0.45%     Total 1/1454 (0.07%)   Mean 0.07%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/44 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/35 (0%)     0/40 (0%)     0/41 (0%)           0/47 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/35 (0%)     1/42 (2%)     0/69 (0%)           0/44 (0%)     0/49 (0%)     1/78 (1%)     |
|                                        0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 1/1302 (0.08%)  Mean 0.09%   SD 0.45%     Total 3/1454 (0.21%)   Mean 0.2%    SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     2/92 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1487 (0.07%)  Mean 0.04%   SD 0.19%     Total 3/1532 (0.2%)    Mean 0.15%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1487 (0.07%)  Mean 0.07%   SD 0.39%     Total 1/1532 (0.07%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1487 (0.07%)  Mean 0.07%   SD 0.39%     Total 1/1532 (0.07%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     1/48 (2%)     1/49 (2%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/59 (2%)           1/48 (2%)     3/50 (6%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 10/1487 (0.67%) Mean 0.64%   SD 0.9%      Total 19/1532 (1.24%)  Mean 1.33%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        1/47 (2%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1487 (0.13%)  Mean 0.15%   SD 0.55%     Total 2/1532 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)     0/48 (0%)     0/49 (0%)           1/50 (2%)     1/49 (2%)     0/49 (0%)     |
|                                        1/47 (2%)     1/48 (2%)     1/49 (2%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/59 (2%)           1/48 (2%)     3/50 (6%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 12/1487 (0.81%) Mean 0.79%   SD 0.96%     Total 21/1532 (1.37%)  Mean 1.47%   SD 1.94%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.04%   SD 0.19%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1508 (0.13%)  Mean 0.12%   SD 0.63%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 4/1558 (0.26%)   Mean 0.25%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 5/1558 (0.32%)   Mean 0.32%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1508 (0.2%)   Mean 0.22%   SD 0.63%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/48 (2%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1498 (0.13%)  Mean 0.15%   SD 0.54%     Total 0/1518 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1498 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1518 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1498 (0%)     Mean 0%      SD 0%        Total 1/1518 (0.07%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/48 (2%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1498 (0.13%)  Mean 0.15%   SD 0.54%     Total 0/1518 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1498 (0%)     Mean 0%      SD 0%        Total 1/1518 (0.07%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/1558 (0.19%)   Mean 0.21%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1558 (0.13%)   Mean 0.14%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 3/1558 (0.19%)   Mean 0.17%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 5/1558 (0.32%)   Mean 0.36%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1558 (0.13%)   Mean 0.11%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     4/50 (8%)     2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        2/50 (4%)     3/50 (6%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     4/50 (8%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 32/1558 (2.05%)  Mean 2.12%   SD 2.58%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 7/1558 (0.45%)   Mean 0.5%    SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     5/50 (10%)    2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     4/50 (8%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     4/50 (8%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 39/1558 (2.5%)   Mean 2.62%   SD 2.86%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/1558 (0.06%)   Mean 0.07%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 0/1558 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1508 (0%)     Mean 0%      SD 0%        Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1508 (0.07%)  Mean 0.07%   SD 0.38%     Total 2/1558 (0.13%)   Mean 0.14%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
